scholarly journals Feasibility and acceptability of conducting HIV vaccine trials in adolescents in South Africa: Going beyond willingness to participate towards implementation

2018 ◽  
Vol 108 (4) ◽  
pp. 291 ◽  
Author(s):  
M Wallace ◽  
K Middelkoop ◽  
P Smith ◽  
C Pike ◽  
T Bennie ◽  
...  
Keyword(s):  
South Africa ◽  
Hiv Vaccine ◽  
Willingness To Participate ◽  
Hiv Vaccine Trials ◽  
Vaccine Trials

Local Knowledge and Experiences of Vaccination: Implications for HIV-Preventive Vaccine Trials in South Africa

2006 ◽  
Vol 34 (1) ◽  
pp. 108-123 ◽  
Author(s):  
Graham Lindegger ◽  
Michael Quayle ◽  
Moses Ndlovu
Keyword(s):  
South Africa ◽  
Religious Beliefs ◽  
Hiv Vaccine ◽  
Willingness To Participate ◽  
Hiv Vaccine Trials ◽  
Vaccine Trials ◽  
Positive Attitudes ◽  
Preventive Vaccine ◽  
Kwazulu Natal ◽  
Negative Effect

This study forms part of the preparation of communities for HIV-preventive vaccine trials in South Africa. On the basis of the assumption that attitudes to any HIV vaccine or vaccine trials will partly be influenced by experiences of vaccination in general, this study aimed to investigate knowledge of, attitudes to, and experiences of vaccination in a small semirural community in KwaZulu-Natal, South Africa. The study also sought to investigate the effect of traditional, cultural, and religious beliefs on attitudes to vaccination, as well as to get some indication of willingness to participate in potential HIV vaccine trials. Overall, the findings reveal a good knowledge of, and positive attitudes to, vaccination, with little negative effect of traditional, cultural, and religious beliefs. The findings also reveal a generally positive attitude to HIV vaccines and vaccine trials. Barriers identified, such as anxiety about safety, were not surprising.

scholarly journals A qualitative assessment of perspectives on the inclusion of adolescents in HIV vaccine trials in South Africa

2010 ◽  
Vol 21 (3) ◽  
pp. 172-176 ◽  
Author(s):  
H B Jaspan ◽  
N F Soka ◽  
C Mathews ◽  
A J Flisher ◽  
D Mark ◽  
...  
Keyword(s):  
South Africa ◽  
Hiv Vaccine ◽  
Qualitative Assessment ◽  
Hiv Vaccine Trials ◽  
Vaccine Trials

Willingness to participate in HIV vaccine research in a peri-urban South African community

2006 ◽  
Vol 17 (3) ◽  
pp. 176-179 ◽  
Author(s):  
J Smit ◽  
K Middelkoop ◽  
L Myer ◽  
S Seedat ◽  
L-G Bekker ◽  
...  
Keyword(s):  
South African ◽  
Hiv Vaccine ◽  
Sub Saharan Africa ◽  
Willingness To Participate ◽  
Vaccine Research ◽  
Substantial Impact ◽  
Hiv Vaccine Trials ◽  
Vaccine Trials ◽  
Urban South ◽  
African Community

Research on willingness to participate in HIV vaccine trials is important in preparations for HIV vaccine research, but there are few data from sub-Saharan Africa. We interviewed 198 individuals in a peri-urban South African community immediately after enrolment into an HIV vaccine preparedness study on their willingness to participate in hypothetical vaccine trials. Overall 23% of participants ( n = 46) said that they would be willing to participate in an HIV vaccine trial. Willingness was associated with increasing age, male gender, and increasing knowledge about vaccines generally and HIV vaccines specifically. In multivariate analysis, a 1-unit increase in HIV vaccine knowledge score was associated with a 10-fold increase in willingness to participate (adjusted odds ratio, 10.72, 95% confidence intervals: 4.40–26.12). These results suggest that while willingness to participate in HIV vaccine trials is relatively low in this setting, educational campaigns may have a substantial impact on individuals' willingness to participate in research.

Willingness to participate in HIV vaccine trials among HIV-negative gay men in Sydney, Australia

2005 ◽  
Vol 16 (4) ◽  
pp. 314-317 ◽  
Author(s):  
Paul Van de Ven ◽  
Limin Mao ◽  
June Crawford ◽  
Garrett Prestage ◽  
Andrew Grulich ◽  
...  
Keyword(s):  
Gay Men ◽  
Tertiary Education ◽  
Anal Intercourse ◽  
Unprotected Anal Intercourse ◽  
Hiv Vaccine ◽  
Willingness To Participate ◽  
Hiv Vaccine Trials ◽  
Vaccine Trials ◽  
Antibody Positivity ◽  
Hiv Negative

This study aimed to determine and describe HIV-negative gay men's willingness to participate in HIV vaccine trials. Data were from participants who completed face-to-face interviews during the first 18 months (to the end of 2002) of recruitment into the Health in Men cohort of HIV-negative gay men in Sydney. A key outcome measure was a scale of Willingness to Participate in HIV Vaccine Trials, with scores ranging from 1 (unwilling) to 4 (willing). The 903 participants ranged in age from 18 to 75years (median=36). Mean of Willingness to Participate in HIV Vaccine Trials was 2.53 (standard deviation=0.54), with approximately 51% of the men having a score greater than the midpoint of 2.50. A reduced linear regression model yielded four significant independent associations with Willingness to Participate in HIV Vaccine Trials: lack of tertiary education ( P <0.001),having engaged 'in the previous six months' in any unprotected anal intercourse with casual or non-concordant regular partners ( P <0.001), higher self-rated likelihood of HIV infection ( P <0.01), and higher mean scores on a scale of Comfort with Participation in HIV VaccineTrials ( P <0.001). The willingness of HIV-negative gay men at potentially higher risk for HIV to participate in HIV vaccine trials augurs well for enrolment in HIV vaccine efficacy trials. Recruitment into trials is likely to be enhanced by addressing salient concerns such as confidentiality and vaccine-induced antibody positivity. Also, it will be important to ensure that gay men are educated and fully informed about HIV vaccines and trial processes.

scholarly journals Recruitment of Urban US Women at Risk for HIV Infection and Willingness to Participate in Future HIV Vaccine Trials

2012 ◽  
Vol 17 (2) ◽  
pp. 760-772 ◽  
Author(s):  
Barbara Metch ◽  
Ian Frank ◽  
Richard Novak ◽  
Edith Swann ◽  
David Metzger ◽  
...  
Keyword(s):  
At Risk ◽  
Hiv Infection ◽  
Hiv Vaccine ◽  
Willingness To Participate ◽  
Hiv Vaccine Trials ◽  
Vaccine Trials
Sign in / Sign up

Export Citation Format

Share Document