scholarly journals Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Liou Y Sun ◽  
Adam Spong ◽  
William R Swindell ◽  
Yimin Fang ◽  
Cristal Hill ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Caloric Restriction ◽  
Stress Resistance ◽  
Growth Hormone Releasing Hormone ◽  
Somatotropic Axis ◽  
Releasing Hormone ◽  
Xenobiotic Detoxification ◽  
Expression Of Genes ◽  
Extended Longevity ◽  
The Impact

We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. These mutant mice also have increased adiponectin levels and alterations in glucose homeostasis consistent with the removal of the counter-insulin effects of growth hormone. While these effects overlap with those of caloric restriction, we show that the effects of caloric restriction (CR) and the GHRH mutation are additive, with lifespan of GHRH-KO mutants further increased by CR. We conclude that GHRH-KO mice feature perturbations in a network of signaling pathways related to stress resistance, metabolic control and inflammation, and therefore provide a new model that can be used to explore links between GHRH repression, downregulation of the somatotropic axis, and extended longevity.

Somatotropic axis dysfunction in critically ill patients: altered response to growth hormone-releasing hormone

2001 ◽  
Vol 38 (3) ◽  
pp. 187-192
Author(s):  
S. Schroeder ◽  
W. Springer ◽  
M. Hashemian ◽  
M. Wichers ◽  
D. Klingmüller ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Growth Hormone Releasing Hormone ◽  
Somatotropic Axis ◽  
Releasing Hormone ◽  
Altered Response

Activation of the Somatotropic Axis by Testosterone in Adult Men: Evidence for a Role of Hypothalamic Growth Hormone-Releasing Hormone

2003 ◽  
Vol 77 (6) ◽  
pp. 380-387 ◽  
Author(s):  
Marta Bondanelli ◽  
Maria Rosaria Ambrosio ◽  
Angelo Margutti ◽  
Paola Franceschetti ◽  
Maria Chiara Zatelli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Releasing Hormone ◽  
Somatotropic Axis ◽  
Releasing Hormone ◽  
Adult Men

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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