scholarly journals Author response: Neural mechanisms of economic commitment in the human medial prefrontal cortex

2014 ◽  
Author(s):  
Konstantinos Tsetsos ◽  
Valentin Wyart ◽  
S Paul Shorkey ◽  
Christopher Summerfield
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Neural Mechanisms ◽  
Author Response

scholarly journals Retrieval practice facilitates memory updating by enhancing and differentiating medial prefrontal cortex representations

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Zhifang Ye ◽  
Liang Shi ◽  
Anqi Li ◽  
Chuansheng Chen ◽  
Gui Xue
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Pattern Analysis ◽  
Retrieval Practice ◽  
Neural Mechanisms ◽  
Neural Activation ◽  
Final Test ◽  
Memory Updating ◽  
Practice Condition ◽  
Memory Integration

Updating old memories with new, more current information is critical for human survival, yet the neural mechanisms for memory updating in general and the effect of retrieval practice in particular are poorly understood. Using a three-day A-B/A-C memory updating paradigm, we found that compared to restudy, retrieval practice could strengthen new A-C memories and reduce old A-B memory intrusion, but did not suppress A-B memories. Neural activation pattern analysis revealed that compared to restudy, retrieval practice led to stronger target representation in the medial prefrontal cortex (MPFC) during the final test. Critically, it was only under the retrieval practice condition that the MPFC showed strong and comparable competitor evidence for both correct and incorrect trials during final test, and that the MPFC target representation during updating was predictive of subsequent memory. These results suggest that retrieval practice is able to facilitate memory updating by strongly engaging MPFC mechanisms in memory integration, differentiation and consolidation.

scholarly journals Neural mechanisms of economic commitment in the human medial prefrontal cortex

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Konstantinos Tsetsos ◽  
Valentin Wyart ◽  
S Paul Shorkey ◽  
Christopher Summerfield
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Neural Mechanisms ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Financial Return ◽  
Economic Decisions ◽  
Decision Biases ◽  
Stimulus Value ◽  
Over Time

Neurobiologists have studied decisions by offering successive, independent choices between goods or gambles. However, choices often have lasting consequences, as when investing in a house or choosing a partner. Here, humans decided whether to commit (by acceptance or rejection) to prospects that provided sustained financial return. BOLD signals in the rostral medial prefrontal cortex (rmPFC) encoded stimulus value only when acceptance or rejection was deferred into the future, suggesting a role in integrating value signals over time. By contrast, the dorsal anterior cingulate cortex (dACC) encoded stimulus value only when participants rejected (or deferred accepting) a prospect. dACC BOLD signals reflected two decision biases–to defer commitments to later, and to weight potential losses more heavily than gains–that (paradoxically) maximised reward in this task. These findings offer fresh insights into the pressures that shape economic decisions, and the computation of value in the medial prefrontal cortex.

scholarly journals Author response: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption

2016 ◽  
Author(s):  
Kristopher McEown ◽  
Yohko Takata ◽  
Yoan Cherasse ◽  
Nanae Nagata ◽  
Kosuke Aritake ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Rem Sleep ◽  
Sleep Loss ◽  
Author Response ◽  
Sucrose Consumption

Author response for "Play, but not observing play, engages rat medial prefrontal cortex"

2020 ◽  
Author(s):  
Miguel Concha‐Miranda ◽  
Konstantin Hartmann ◽  
Annika Reinhold ◽  
Michael Brecht ◽  
Juan I. Sanguinetti‐Scheck
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Author Response

scholarly journals Author response: Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

2020 ◽  
Author(s):  
Stavros Trakoshis ◽  
Pablo Martínez-Cañada ◽  
Federico Rocchi ◽  
Carola Canella ◽  
Wonsang You ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Author Response ◽  
Intrinsic Excitation
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