scholarly journals Decoding gripping force based on local field potentials recorded from subthalamic nucleus in humans

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Huiling Tan ◽  
Alek Pogosyan ◽  
Keyoumars Ashkan ◽  
Alexander L Green ◽  
Tipu Aziz ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Field Potential ◽  
Field Potentials ◽  
Movement Parameters ◽  
Gripping Force ◽  
And Control ◽  
Local Field Potential Lfp ◽  
Deep Brain

The basal ganglia are known to be involved in the planning, execution and control of gripping force and movement vigour. Here we aim to define the nature of the basal ganglia control signal for force and to decode gripping force based on local field potential (LFP) activities recorded from the subthalamic nucleus (STN) in patients with deep brain stimulation (DBS) electrodes. We found that STN LFP activities in the gamma (55–90 Hz) and beta (13–30m Hz) bands were most informative about gripping force, and that a first order dynamic linear model with these STN LFP features as inputs can be used to decode the temporal profile of gripping force. Our results enhance the understanding of how the basal ganglia control gripping force, and also suggest that deep brain LFPs could potentially be used to decode movement parameters related to force and movement vigour for the development of advanced human-machine interfaces.

scholarly journals Edge detections of MER Signals of STN with DBS micro electrode local field potential acquisitions in Parkinson`s

2022 ◽  
Vol 7 (4) ◽  
pp. 281-286
Author(s):  
Venkateshwarla Rama Raju
Keyword(s):  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Local Field ◽  
Brain Stimulation ◽  
Field Potential ◽  
Field Potentials ◽  
Thalamic Nuclei ◽  
Motor Functioning ◽  
Potential Activity ◽  
Deep Brain

Deep brain stimulation of the subthalamic nucleus (STN) is a highly effective treatment for motor symptoms of Parkinson’s disease. Sub thalamic nucleus deep brain stimulation (STN-DBS) is a therapeutic surgical procedure for reducing the symptoms Parkinson’s and restoring and increasing the motor functioning. However, precise intraoperative edge or perimeter detection of STN remains a procedural challenge. In this study, we present the micro electrode signals recordings (MER) of STNs and local field potentials (LFPs) were acquired from deep brain stimulation macro electrodes during trajectory towards STN, in Parkinson patients. The frequency versus intensity atlas of field potential activity was obtained and further than investigated in distinct sub band’s, to explore whether field potentials activity can be employed for STN edge detection. STN perimeter detections by means of L F Ps were evaluated to edge predictions by way of the functional stereotactic DBS neurosurgeon, based on micro electrode derived, single unit recordings (M E R – S N A of S T Ns). The findings show variation amongst M E R – S N A and macro electrode L F P-signals gathering through MER-system pertaining to the d o r s a l S T N b o r d e r of -1.00±0.85mm plus -0.42±1.08 mm in the and frequencies, correspondingly. For these sub band`s, root mean square of the voids was found to be 1.27milli meters and 1.07milli meters. The Assessment of other sub band`s didn`t set a limit for differentiating the posterior (c a u d a l) point of sub-thalamic nuclei. We may infer that In conclusion, macro electrode signal acquisitions of STNs derived L F P gatherings might offer an unconventional methodology in the direction of m e r – s n a, for detecting the aimed target subthalamic nucleus borders during DBS-surgery.

Basal ganglia local field potentials: applications in the development of new deep brain stimulation devices for movement disorders

2007 ◽  
Vol 4 (5) ◽  
pp. 605-614 ◽  
Author(s):  
Sara Marceglia ◽  
Lorenzo Rossi ◽  
Guglielmo Foffani ◽  
AnnaMaria Bianchi ◽  
Sergio Cerutti ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Local Field ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Local Field Potentials ◽  
Field Potentials ◽  
Deep Brain

scholarly journals Local vs. volume conductance activity of field potentials in the human subthalamic nucleus

2017 ◽  
Vol 117 (6) ◽  
pp. 2140-2151 ◽  
Author(s):  
Odeya Marmor ◽  
Dan Valsky ◽  
Mati Joshua ◽  
Atira S Bick ◽  
David Arkadir ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Neuronal Activity ◽  
Brain Stimulation ◽  
Closed Loop ◽  
Field Potential ◽  
Cortical Activity ◽  
Field Potentials ◽  
Brain Functions ◽  
Deep Brain

Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume conductance of the organized neuronal activity generated in the cortex. This study aimed at understanding of the physiological origin of subthalamic field potentials and determining the most accurate method for recording them. We compared different methods of recordings in the human subthalamic nucleus: spikes (300–9,000 Hz) and field potentials (3–100 Hz) recorded by monopolar micro- and macroelectrodes, as well as by differential-bipolar macroelectrodes. The recordings were done outside and inside the subthalamic nucleus during electrophysiological navigation for deep brain stimulation procedures (150 electrode trajectories) in 41 Parkinson’s disease patients. We modeled the signal and estimated the contribution of nearby/independent vs. remote/common activity in each recording configuration and area. Monopolar micro- and macroelectrode recordings detect field potentials that are considerably affected by common (probably cortical) activity. However, bipolar macroelectrode recordings inside the subthalamic nucleus can detect locally generated potentials. These results are confirmed by high correspondence between the model predictions and actual correlation of neuronal activity recorded by electrode pairs. Differential bipolar macroelectrode subthalamic field potentials can overcome volume conductance effects and reflect locally generated neuronal activity. Bipolar macroelectrode local field potential recordings might be used as a biological marker of normal and pathological brain functions for future electrophysiological studies and navigation systems as well as for closed-loop deep brain stimulation paradigms. NEW & NOTEWORTHY Our results integrate a new method for human subthalamic recordings with a development of an advanced mathematical model. We found that while monopolar microelectrode and macroelectrode recordings detect field potentials that are considerably affected by common (probably cortical) activity, bipolar macroelectrode recordings inside the subthalamic nucleus (STN) detect locally generated potentials that are significantly different than those recorded outside the STN. Differential bipolar subthalamic field potentials can be used in navigation and closed-loop deep brain stimulation paradigms.

7 Converging evidence from local field potentials and acute stimulation for subthalamic nucleus theta involvement in internally generated decisions to initiate or withhold actions

2020 ◽  
Vol 91 (8) ◽  
pp. e10.3-e11
Author(s):  
Luis Manssuer ◽  
Valerie Voon ◽  
Chen Cheng Zhang ◽  
Linbin Wang
Keyword(s):  
Subthalamic Nucleus ◽  
Local Field ◽  
Visual Cues ◽  
Local Field Potentials ◽  
Theta Activity ◽  
Field Potentials ◽  
Theta Frequency ◽  
The Right ◽  
Deep Brain

Objectives/AimsTo examine the causal role of the subthalamic nucleus (STN) in externally cued or internally generated decisions to execute or withhold an action by recording and stimulating neural activity in this region using deep brain stimulation (DBS) electrodes implanted for the treatment of Parkinson’s disease (PD).Methods20 PD patients completed an intentional inhibition task in which they were instructed by visual cues to go, stop or choose to go or stop. Each cue was on the screen until the patient pressed a button with their left thumb or for a maximum of 1500 ms and was preceded by a fixation cross for 1000–1500 ms. Local field potentials (LFP) were simultaneously recorded from the left STN and stimulated in the right STN at the clinical frequency of 130Hz or theta frequency 7Hz for 500 ms prior to the onset of the cue on half of the choice trials.ResultsOn non-stimulation choice trials, analysis of the LFP’s showed a significant decrease in theta activity when patients chose to stop compared to go. This difference began prior to the onset of the response. Behaviourally, patients chose to respond less when the STN was stimulated at a frequency of 7 hz for 500 ms prior to the onset of the cue but not at 130 Hz.On non-stimulation choice trials, analysis of the LFP’s also showed that there was a significant decrease in theta activity when patients chose to stop compared to go. This difference began prior to the onset of the response.ConclusionsThe findings suggest that pre-existing theta activity in the STN may bias one’s pre-disposition to choose to initiate an action and that stimulation of this activity may interfere with this process.

Sign in / Sign up

Export Citation Format

Share Document