scholarly journals Decision letter: An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

2018 ◽  
Keyword(s):  
Germ Cell ◽  
Splice Site ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cryptic Splice Site

scholarly journals Author response: An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

2018 ◽  
Author(s):  
Ingrid Ehrmann ◽  
James H Crichton ◽  
Matthew R Gazzara ◽  
Katherine James ◽  
Yilei Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Splice Site ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Author Response ◽  
Cryptic Splice Site

scholarly journals An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Ingrid Ehrmann ◽  
James H Crichton ◽  
Matthew R Gazzara ◽  
Katherine James ◽  
Yilei Liu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Splice Site ◽  
Cell Biology ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Aberrant Splice ◽  
Splice Site Selection ◽  
Ambient Concentrations ◽  
Splicing Patterns

Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks spermatogenesis. Transcriptome analyses of age-matched deletion mice show that RBMXL2 controls splicing patterns during meiosis. In particular, RBMXL2 represses the selection of aberrant splice sites and the insertion of cryptic and premature terminal exons. Our data suggest a Rbmxl2 retrogene has been conserved across mammals as part of a splicing control mechanism that is fundamentally important to germ cell biology. We propose that this mechanism is essential to meiosis because it buffers the high ambient concentrations of splicing activators, thereby preventing poisoning of key transcripts and disruption to gene expression by aberrant splice site selection.

RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours

2011 ◽  
Vol 59 (3) ◽  
pp. 452-459 ◽  
Author(s):  
Debin Xue ◽  
Yan Peng ◽  
Fenghua Wang ◽  
Robert W Allan ◽  
Dengfeng Cao
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Germ Cell Tumours ◽  
Sensitive Marker

The RNA-Binding Protein TIA-1 Is a Novel Mammalian Splicing Regulator Acting through Intron Sequences Adjacent to a 5′ Splice Site

2000 ◽  
Vol 20 (17) ◽  
pp. 6287-6299 ◽  
Author(s):  
Fabienne Del Gatto-Konczak ◽  
Cyril F. Bourgeois ◽  
Caroline Le Guiner ◽  
Liliane Kister ◽  
Marie-Claude Gesnel ◽  
...  
Keyword(s):  
Splice Site ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Splicing Regulator

scholarly journals Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse

2008 ◽  
Vol 17 (18) ◽  
pp. 2803-2818 ◽  
Author(s):  
Ingrid Ehrmann ◽  
Caroline Dalgliesh ◽  
Aikaterini Tsaousi ◽  
Maria Paola Paronetto ◽  
Bettina Heinrich ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Nuclear Rna

scholarly journals RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases

2010 ◽  
Vol 24 (2) ◽  
pp. 288-296 ◽  
Author(s):  
Dengfeng Cao ◽  
Aijun Liu ◽  
Fenghua Wang ◽  
Robert W Allan ◽  
Kaiyong Mei ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Immunohistochemical Study ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Germ Cell Tumors ◽  
Extragonadal Germ Cell Tumors

scholarly journals Male Germ Cell-Specific RNA Binding Protein RBMY: A New Oncogene Explaining Male Predominance in Liver Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e26948 ◽  
Author(s):  
Daw-Jen Tsuei ◽  
Po-Huang Lee ◽  
Hsiao-Yu Peng ◽  
Shau-Lin Lu ◽  
De-Shiuan Su ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Male Germ Cell ◽  
Male Predominance

RNA binding protein Musashi‐1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus

2015 ◽  
Vol 29 (7) ◽  
pp. 2759-2768 ◽  
Author(s):  
Jessie M. Sutherland ◽  
Alexander P. Sobinoff ◽  
Barbara A. Fraser ◽  
Kate A. Redgrove ◽  
Tara‐Lynne Davidson ◽  
...  
Keyword(s):  
Germ Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Development ◽  
Germ Cell Development
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