scholarly journals Decision letter: Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

2019 ◽  
Author(s):  
Bart Deplancke
Keyword(s):  
Temporal Patterning ◽  
Cellular Hierarchy

scholarly journals Author response: Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

2019 ◽  
Author(s):  
Sara Genovese ◽  
Raphaël Clément ◽  
Cassandra Gaultier ◽  
Florence Besse ◽  
Karine Narbonne-Reveau ◽  
...  
Keyword(s):  
Author Response ◽  
Temporal Patterning ◽  
Cellular Hierarchy

scholarly journals Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Sara Genovese ◽  
Raphaël Clément ◽  
Cassandra Gaultier ◽  
Florence Besse ◽  
Karine Narbonne-Reveau ◽  
...  
Keyword(s):  
Numerical Modeling ◽  
Clonal Analysis ◽  
Cell Heterogeneity ◽  
Cell Of Origin ◽  
Temporal Patterning ◽  
Growth Properties ◽  
Patterning Genes ◽  
Cellular Hierarchy ◽  
Early Developmental ◽  
Developmental Window

It is still unclear what drives progression of childhood tumors. During Drosophila larval development, asymmetrically-dividing neural stem cells, called neuroblasts, progress through an intrinsic temporal patterning program that ensures cessation of divisions before adulthood. We previously showed that temporal patterning also delineates an early developmental window during which neuroblasts are susceptible to tumor initiation (Narbonne-Reveau et al., 2016). Using single-cell transcriptomics, clonal analysis and numerical modeling, we now identify a network of twenty larval temporal patterning genes that are redeployed within neuroblast tumors to trigger a robust hierarchical division scheme that perpetuates growth while inducing predictable cell heterogeneity. Along the hierarchy, temporal patterning genes define a differentiation trajectory that regulates glucose metabolism genes to determine the proliferative properties of tumor cells. Thus, partial redeployment of the temporal patterning program encoded in the cell of origin may govern the hierarchy, heterogeneity and growth properties of neural tumors with a developmental origin.

scholarly journals Temporal patterning in neural progenitors: from Drosophila development to childhood cancers

2020 ◽  
Vol 13 (7) ◽  
pp. dmm044883 ◽  
Author(s):  
Cédric Maurange
Keyword(s):  
Rna Binding ◽  
Rna Binding Proteins ◽  
Cancer Susceptibility ◽  
Pediatric Brain Tumors ◽  
Neural Progenitors ◽  
Childhood Cancers ◽  
Temporal Patterning ◽  
Underlying Mechanisms ◽  
Cellular Hierarchy ◽  
Pediatric Brain

ABSTRACTThe developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased proliferation, which are often observed during embryonic and fetal stages and reflect stereotypical changes in the proliferative properties of neural progenitors. The temporal mechanisms underlying these proliferation patterns are still unclear in mammals. In Drosophila, two decades of work have revealed a network of sequentially expressed transcription factors and RNA-binding proteins that compose a neural progenitor-intrinsic temporal patterning system. Temporal patterning controls both the identity of the post-mitotic progeny of neural progenitors, according to the order in which they arose, and the proliferative properties of neural progenitors along development. In addition, in Drosophila, temporal patterning delineates early windows of cancer susceptibility and is aberrantly regulated in developmental tumors to govern cellular hierarchy as well as the metabolic and proliferative heterogeneity of tumor cells. Whereas recent studies have shown that similar genetic programs unfold during both fetal development and pediatric brain tumors, I discuss, in this Review, how the concept of temporal patterning that was pioneered in Drosophila could help to understand the mechanisms of initiation and progression of CNS tumors in children.

scholarly journals Spatio‐temporal patterning of arginyl‐ tRNA protein transferase ( ATE ) contributes to gametophytic development in a moss

2015 ◽  
Vol 209 (3) ◽  
pp. 1014-1027 ◽  
Author(s):  
Christian Schuessele ◽  
Sebastian N. W. Hoernstein ◽  
Stefanie J. Mueller ◽  
Marta Rodriguez‐Franco ◽  
Timo Lorenz ◽  
...  
Keyword(s):  
Temporal Patterning ◽  
Spatio Temporal

Liturgy and Public Theology

2020 ◽  
Vol 102 (2) ◽  
pp. 219-229
Author(s):  
James W. Farwell
Keyword(s):  
Jesus Christ ◽  
Point Of View ◽  
The Body ◽  
Public Theology ◽  
Temporal Patterning ◽  
Ritual Performance ◽  
Reign Of God

Liturgy is an act of public theology, when considered from the point of view that Christian ritual performance is publicly enacted for the sake of a wider public, and joins the assembly to Jesus Christ, who is himself God's logos tou theou and God's liturgy. Liturgy does this work through its scripted repetition, formality, spatial and temporal patterning, focus on the body, and deployment of the familiar and unfamiliar. Through these modes, a worldview is enacted and valorizes a certain set of virtues and an orientation to living that correspond to that worldview. Among those virtues are gratitude, a desire for reconciliation, the recognition of our dependency of God and responsibility toward others, and a compassionate commitment to the dignity of humanity and the created order. These ritually enacted virtues, practiced in the hope for the full and coming reign of God, will orient the liturgical assembly to particular social, moral, political concerns as worthy of Christian engagement; but liturgical formation will not, in most cases, prescribe detailed courses of action to take when facing specific instances of those concerns.

scholarly journals The Dynamics of Prioritizing: How Actors Temporally Pattern Complex Role–Routine Ecologies

2020 ◽  
pp. 000183922094848
Author(s):  
Waldemar Kremser ◽  
Blagoy Blagoev
Keyword(s):  
Complex Problem ◽  
Project Team ◽  
Ethnographic Study ◽  
Work Setting ◽  
Temporal Patterning ◽  
Temporal Coordination ◽  
Work Settings

This paper examines the emergence of temporal coordination among multiple interdependent routines in a complex work setting that does not allow for up-front scheduling. We propose that when actors continuously have to prioritize their expected contributions to multiple interdependent routines, they address this challenge by orienting not just toward routines but also toward person-roles. Drawing on an ethnographic study of an agile consulting project team confronted with continued scheduling failures, we demonstrate how the dynamics of prioritizing enabled the actors to resolve what at first appeared to be an irresolvable and highly complex problem of temporal coordination. We add to the literature on routine dynamics and temporality by setting forth the dynamics of prioritizing as an explanation for the temporal patterning of complex work settings. We introduce the notion of role–routine ecologies as a novel way to conceptualize such complex work settings and contribute to developing a performative theory of person-roles and their significance for coordinating.

Temporal patterning of blooming phenology in Pedicularis on Mount Rainier

1983 ◽  
Vol 61 (3) ◽  
pp. 786-791 ◽  
Author(s):  
Virginia Dale Adams
Keyword(s):  
Pollen Grains ◽  
Growing Season ◽  
Sympatric Species ◽  
Temporal Patterning ◽  
Flowering Pattern ◽  
Subalpine Meadow ◽  
Evolutionary Force ◽  
Mount Rainier ◽  
Pollinator Sharing ◽  
Blooming Phenology

The temporal patterning of flowering of five sympatric species of Pedicularis in a subalpine meadow is documented. Two species bloom early in the growing season, one is intermediate, and two flower toward the later part of the season. The differences between species are related to the range of blooming periods (in days), the number of inflorescences at maximum bloom, and the time of peak bloom. No significant variation in flowering pattern occurred during the years of observation (1977, 1978, and 1979). More than 93% of the time individual bumblebees continued to forage on the same Pedicularis species as was previously visited; yet when switches in the diet of the bees occurred, they were more likely to be to another species of Pedicularis. Although individuals of other genera were in bloom, the bees switched to the Pedicularis species most synchronous in time and space to the previously preferred Pedicularis species. Counts were made of the number of pollen grains per flower, the reward for foraging bees. The last species to flower had the greatest reward but also had the largest ratio of the number of pollen grains to the number of ovules as compared with the previously flowering Pedicularis species. These results suggest that pollinator sharing is an important evolutionary force but that the quantity of the pollen reward may be more related to the number of ovules.

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