scholarly journals Author response: A circuit mechanism for decision-making biases and NMDA receptor hypofunction

2020 ◽  
Author(s):  
Sean Edward Cavanagh ◽  
Norman H Lam ◽  
John D Murray ◽  
Laurence Tudor Hunt ◽  
Steven Wayne Kennerley
eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Sean Edward Cavanagh ◽  
Norman H Lam ◽  
John D Murray ◽  
Laurence Tudor Hunt ◽  
Steven Wayne Kennerley

Decision-making biases can be features of normal behaviour, or deficits underlying neuropsychiatric symptoms. We used behavioural psychophysics, spiking-circuit modelling and pharmacological manipulations to explore decision-making biases during evidence integration. Monkeys showed a pro-variance bias (PVB): a preference to choose options with more variable evidence. The PVB was also present in a spiking circuit model, revealing a potential neural mechanism for this behaviour. To model possible effects of NMDA receptor (NMDA-R) antagonism on this behaviour, we simulated the effects of NMDA-R hypofunction onto either excitatory or inhibitory neurons in the model. These were then tested experimentally using the NMDA-R antagonist ketamine, a pharmacological model of schizophrenia. Ketamine yielded an increase in subjects’ PVB, consistent with lowered cortical excitation/inhibition balance from NMDA-R hypofunction predominantly onto excitatory neurons. These results provide a circuit-level mechanism that bridges across explanatory scales, from the synaptic to the behavioural, in neuropsychiatric disorders where decision-making biases are prominent.


2019 ◽  
Author(s):  
Sean E. Cavanagh ◽  
Norman H. Lam ◽  
John D. Murray ◽  
Laurence T. Hunt ◽  
Steven W. Kennerley

AbstractDecision-making biases can be systematic features of normal behaviour, or deficits underlying neuropsychiatric symptoms. We used behavioural psychophysics, spiking-circuit modelling and pharmacological manipulations to explore decision-making biases in health and disease. Monkeys performed an evidence integration task in which they showed a pro-variance bias (PVB): a preference to choose options with more variable evidence. The PVB was also present in a spiking circuit model, revealing a neural mechanism for this behaviour. Because NMDA receptor (NMDA-R) hypofunction is a leading hypothesis for neuropathology in schizophrenia, we simulated behavioural effects of NMDA-R hypofunction onto either excitatory or inhibitory neurons in the model. These were tested experimentally using the NMDA-R antagonist ketamine, yielding changes in decision-making consistent with lowered cortical excitation/inhibition balance from NMDA-R hypofunction onto excitatory neurons. These results provide a circuit-level mechanism that bridges across explanatory scales, from the synaptic to the behavioural, in neuropsychiatric disorders where decision-making biases are prominent.SignificancePeople can make apparently irrational decisions because of underlying features in their decision circuitry. Deficits in the same neural circuits may also underlie debilitating cognitive symptoms of neuropsychiatric patients. Here, we reveal a neural circuit mechanism explaining an irrationality frequently observed in healthy humans making binary choices – the pro-variance bias. Our circuit model could be perturbed by introducing deficits in either excitatory or inhibitory neuron function. These two perturbations made specific, dissociable predictions for the types of irrational decisionmaking behaviour produced. We used the NMDA-R antagonist ketamine, an experimental model for schizophrenia, to test if these predictions were relevant to neuropsychiatric pathophysiology. The results were consistent with impaired excitatory neuron function, providing important new insights into the pathophysiology of schizophrenia.


2011 ◽  
Author(s):  
Kimia Honarmand ◽  
Stephanie Bass ◽  
Martina-Christina Kalahani-Bargis ◽  
David S. Nussbaum

2018 ◽  
Vol 9 (1) ◽  
pp. 59-66
Author(s):  
Zsuzsanna Gödör ◽  
Georgina Szabó

Abstract As they say, money can’t buy happiness. However, the lack of it can make people’s lives much harder. From the moment we open our first bank account, we have to make lots of financial decisions in our life. Should I save some money or should I spend it? Is it a good idea to ask for a loan? How to invest my money? When we make such decisions, unfortunately we sometimes make mistakes, too. In this study, we selected seven common decision making biases - anchoring and adjustment, overconfidence, high optimism, the law of small numbers, framing effect, disposition effect and gambler’s fallacy – and tested them on the Hungarian population via an online survey. In the focus of our study was the question whether the presence of economic knowledge helps people make better decisions? The decision making biases found in literature mostly appeared in the sample as well. It proves that people do apply them when making decisions and in certain cases this could result in serious and costly errors. That’s why it would be absolutely important for people to learn about them, thus increasing their awareness and attention when making decisions. Furthermore, in our research we did find some connection between decisions and the knowledge of economics, people with some knowledge of economics opted for the better solution in bigger proportion


2012 ◽  
Vol 2 (6) ◽  
pp. 1957-1964 ◽  
Author(s):  
Pouria Nouri ◽  
Behrooz Jamali ◽  
Ehsan Ghasemi

2019 ◽  
Author(s):  
Satoko Amemori ◽  
Ken‐ichi Amemori ◽  
Tomoko Yoshida ◽  
Georgios K. Papageorgiou ◽  
Rui Xu ◽  
...  

2019 ◽  
Author(s):  
Kristina G. Baumgart ◽  
Petr Byvshev ◽  
Alexa‐Nicole Sliby ◽  
Andreas Strube ◽  
Peter König ◽  
...  

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