scholarly journals Author response: Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

2020 ◽  
Author(s):  
Kevin G Burfeind ◽  
Xinxia Zhu ◽  
Mason A Norgard ◽  
Peter R Levasseur ◽  
Christian Huisman ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Central Nervous System ◽  
Nervous System ◽  
Myeloid Cells ◽  
Author Response ◽  
The Central Nervous System

scholarly journals Ly-6G+CCR2−Myeloid Cells Rather Than Ly-6ChighCCR2+Monocytes Are Required for the Control of Bacterial Infection in the Central Nervous System

2008 ◽  
Vol 181 (4) ◽  
pp. 2713-2722 ◽  
Author(s):  
Alexander Mildner ◽  
Marija Djukic ◽  
David Garbe ◽  
Andreas Wellmer ◽  
William A. Kuziel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Bacterial Infection ◽  
Myeloid Cells ◽  
The Central Nervous System

Myeloid cells: The Trojan horse for T cell invasion into the brain

2019 ◽  
Vol 11 (520) ◽  
pp. eaaz9757
Author(s):  
Gilbert Gallardo
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
Cell Invasion ◽  
Myeloid Cells ◽  
Autoimmune Encephalomyelitis ◽  
Lectin Receptors ◽  
The Central Nervous System ◽  
The Brain ◽  
Experimental Autoimmune

C-type lectin receptors on myeloid cells regulate the activation and infiltration of T cells into the central nervous system in experimental autoimmune encephalomyelitis.

Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system

2004 ◽  
Vol 7 (2) ◽  
pp. 167-180 ◽  
Author(s):  
Olivier F. Join-Lambert ◽  
Sophie Ezine ◽  
Alban Le Monnier ◽  
Francis Jaubert ◽  
Masaru Okabe ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Listeria Monocytogenes ◽  
Myeloid Cells ◽  
Bacterial Invasion ◽  
The Central Nervous System

scholarly journals Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

Immunity ◽  
2008 ◽  
Vol 28 (5) ◽  
pp. 675-686 ◽  
Author(s):  
Marco Prinz ◽  
Hauke Schmidt ◽  
Alexander Mildner ◽  
Klaus-Peter Knobeloch ◽  
Uwe-Karsten Hanisch ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Myeloid Cells ◽  
The Central Nervous System

scholarly journals Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Kevin G Burfeind ◽  
Xinxia Zhu ◽  
Mason A Norgard ◽  
Peter R Levasseur ◽  
Christian Huisman ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Cell ◽  
Purinergic Receptor ◽  
Myeloid Cells ◽  
Myeloid Cell ◽  
Ductal Adenocarcinoma ◽  
The Central Nervous System ◽  
Velum Interpositum ◽  
The Brain

Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed early and robust myeloid cell infiltration into the brain. Infiltrating immune cells were predominately neutrophils, which accumulated at a unique central nervous system entry portal called the velum interpositum, where they expressed CCR2. Pharmacologic CCR2 blockade and genetic deletion of Ccr2 both resulted in significantly decreased brain-infiltrating myeloid cells as well as attenuated cachexia during PDAC. Lastly, intracerebroventricular blockade of the purinergic receptor P2RX7 during PDAC abolished immune cell recruitment to the brain and attenuated anorexia. Our data demonstrate a novel function for the CCR2/CCL2 axis in recruiting neutrophils to the brain, which drives anorexia and muscle catabolism.

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