scholarly journals PS4 Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal malaria infection(Role of cytokine networks in parasite-infected hosts)

2001 ◽  
Vol 52 (Supplement) ◽  
pp. 76
Author(s):  
Tohru SAKAI ◽  
Kunisuke HIMENO
Keyword(s):  
Malaria Infection ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Gene Gun ◽  
Expression Plasmid ◽  
Merozoite Surface Protein 1 ◽  
Cytokine Networks

scholarly journals Oral Immunization with a Combination of Plasmodium yoelii Merozoite Surface Proteins 1 and 4/5 Enhances Protection against Lethal Malaria Challenge

2004 ◽  
Vol 72 (10) ◽  
pp. 6172-6175 ◽  
Author(s):  
Lina Wang ◽  
Matthew W. Goschnick ◽  
Ross L. Coppel
Keyword(s):  
Escherichia Coli ◽  
Malaria Infection ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Oral Immunization ◽  
Plasmodium Yoelii ◽  
Antibody Responses ◽  
Surface Proteins ◽  
Merozoite Surface Protein 1

ABSTRACT Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection. A combination of these two proteins administered orally conferred improved protection compared to that conferred by either protein administered alone.

scholarly journals Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum

2001 ◽  
Vol 69 (2) ◽  
pp. 1207-1211 ◽  
Author(s):  
David R. Cavanagh ◽  
Carlota Dobaño ◽  
Ibrahim M. Elhassan ◽  
Kevin Marsh ◽  
Ahmed Elhassan ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Immunoglobulin G ◽  
Malaria Infection ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Igg Subclass ◽  
Polymorphic Region ◽  
Merozoite Surface Protein 1 ◽  
Single Protein ◽  
Immunoglobulin G Subclass

ABSTRACT Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-119 are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

scholarly journals Structure of the merozoite surface protein 1 from Plasmodium falciparum

2021 ◽  
Vol 7 (23) ◽  
pp. eabg0465
Author(s):  
Patricia M. Dijkman ◽  
Tanja Marzluf ◽  
Yingyi Zhang ◽  
Shih-Ying Scott Chang ◽  
Dominic Helm ◽  
...  
Keyword(s):  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Coiled Coils ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Merozoite Surface Protein 1 ◽  
Dimerization Interface ◽  
Structural Insights ◽  
Promising Vaccine Candidate

The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading Plasmodium merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in Plasmodium infection and immunity.

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