Changes in Prealbumin and Body Mass Index Associated with T Lymphocyte Subsets and Nutritional Status in Chronic Hepatitis B and HBV-Cirrhosis Patients

ABSTRACT Background - There have been limited studies investigating the impact of chronic hepatitis B virus infection on the growth of children. Objective - Our objective was to investigate the prevalence of malnutrition in children with chronic hepatitis B infection. Methods - The nutritional status of patients was retrospectively evaluated in the outpatient Clinic of Pediatric Gastroenterology between February and November 2014. During the study, biochemical laboratory parameters, duration of disease, liver biopsy scores, and medication were evaluated. Additionally body mass index and body mass index centiles were calculated. Results - Of the 96 patients in this study, 68 were male and 28 were female, and the mean age was 144.7±43.9 months and 146.1±47.3 months, respectively. According to body mass index centiles five (5.2%) patients were underweight, seven (7.3%) patients were overweight, and seven (7.3%) patients were obese. Conclusions - Moderate rates of malnutrition (including obesity) were found in chronic hepatitis B infection. Additional nutritional status information of healthy and sick children should be assessed in the infection's early period, and timely interventions should be initiated.

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Elevated levels of serum soluble E-selectin in patients with chronic hepatitis B: Correlation with T lymphocyte subsets, NK cells and liver inflammation

Hepatology Research ◽

10.1016/j.hepres.2006.03.006 ◽

2006 ◽

Vol 35 (2) ◽

pp. 111-117 ◽

Cited By ~ 10

Author(s):

M YAN ◽

H MAO ◽

Q LIU ◽

W WANG ◽

Y LI

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Nk Cells ◽

Chronic Hepatitis B ◽

T Lymphocyte ◽

Lymphocyte Subsets ◽

Liver Inflammation ◽

T Lymphocyte Subsets ◽

Soluble E Selectin

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Impact of body mass index and viral load on liver histology in hepatitis B e antigen-negative chronic hepatitis B

Clinical Nutrition ◽

10.1016/j.clnu.2011.05.001 ◽

2011 ◽

Vol 30 (5) ◽

pp. 647-652 ◽

Cited By ~ 13

Author(s):

I-Cheng Lee ◽

Yi-Hsiang Huang ◽

Che-Chang Chan ◽

Teh-Ia Huo ◽

Chi-Jen Chu ◽

...

Keyword(s):

Body Mass Index ◽

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Body Mass ◽

Liver Histology ◽

Hepatitis B E Antigen ◽

Negative Chronic Hepatitis

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Longitudinal Change of Body Mass Index Is Associated With Alanine Aminotransferase Elevation After Complete Viral Suppression in Chronic Hepatitis B Patients

The Journal of Infectious Diseases ◽

10.1093/infdis/jiz326 ◽

2019 ◽

Vol 220 (9) ◽

pp. 1469-1476 ◽

Cited By ~ 2

Author(s):

Kaifeng Wang ◽

Weiyin Lin ◽

Zhe Kuang ◽

Rong Fan ◽

Xieer Liang ◽

...

Keyword(s):

Body Mass Index ◽

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Body Mass ◽

Alanine Aminotransferase ◽

Viral Suppression ◽

Low Bmi ◽

High Bmi

Abstract Background Little is known about cause and intervention for alanine aminotransferase (ALT) elevation after complete viral suppression in patients with chronic hepatitis B (CHB). Methods In this prospective cohort study, patients with CHB who were treated with nucleos(t)ide analogs and maintained undetectable levels of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) for at least 6 months were enrolled. Patients were followed up at 6-month intervals, and anthropometric, biochemical, and virological assessments were performed. Results Of 1965 patients with median follow-up of 18.36 months, one third of patients experienced ALT elevation. Baseline high body mass index ([BMI] defined as ≥25 kg/m2), younger age, and liver cirrhosis independently increased the risk of longitudinal ALT elevation. At the end of follow-up, 89 (4.8%) patients reverted to low BMI, and 92 (5.0%) developed to high BMI. Compared with persistent high BMI, reversion to low BMI reduced the risk of ALT elevation (adjusted odds ratio [aOR], 0.38; 95% confidence interval [CI], 0.19–0.77); compared with persistent low BMI, onset of high BMI increased the risk of ALT elevation (aOR, 1.78; 95% CI, 1.02–3.11). Conclusions High BMI is an independent predictor for ALT elevation after complete HBV DNA suppression. Improvement of BMI may have a beneficial effect on ALT normalization and even long-term outcomes.

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