An Interesting Case of Serratia Endocarditis in a Patient With Chronic Myeloid Leukemia

Blast crisis develops in a minority of patients with chronic myeloid leukemia even in the era of tyrosine kinase inhibitor (TKI) therapy. Reports suggest that we know little about the mechanism of BCR-ABL and AML1-ETO co-expression in blast crisis of chronic myeloid leukemia, and that other chromosomal abnormalities also coexist. Here, we document an unusual and interesting case of a 51-year-old female diagnosed in the chronic phase of chronic myeloid leukemia. After undergoing TKI treatment for 3 months, her bone marrow aspirates in the chronic phase had transformed to blast crisis. Molecular genetic testing indicated she was positive for p210 form of BCR-ABL (copy number decreased from 108.91% to 56.96%) and AML1-ETO fusion (copy number, 5.65%) genes and had additional chromosomal abnormalities of t(8; 21)(q22; q22)/t(9; 22)(q34; q11), t(2; 5)(p24; q13) and an additional +8 chromosome.

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An interesting case of chronic myeloid leukemia (CML) with T315I mutation raising suspicion of de novo AML, a diagnostic conundrum.

10.22541/au.161819718.83894200/v1 ◽

2021 ◽

Author(s):

Phool Iqbal ◽

Aamir Shahzad ◽

Zubair Shahid ◽

Aden Iqbal ◽

Muhammad Sohaib Qamar ◽

...

Keyword(s):

Chronic Myeloid Leukemia ◽

Myeloid Leukemia ◽

De Novo ◽

Philadelphia Chromosome ◽

Interesting Case ◽

Myeloproliferative Disorder ◽

World Health ◽

T315i Mutation ◽

De Novo Aml ◽

Health Organization

Chronic myeloid leukemia (CML) is a myeloproliferative disorder due to translocation between chromosomes (9, 22), known as the “Philadelphia chromosome.” In 2016, the World health organization (WHO) introduced a new clinical entity of de novo acute myeloid leukemia (AML). Both diseases share some commonalities, therefore, create a challenge to diagnose.

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Chronic myeloid leukemia revealed by bilateral proliferative retinopathy: A case report and literature review

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2021.7.1.0090 ◽

2021 ◽

Vol 7 (1) ◽

pp. 157-160

Author(s):

Wafa Quiddi ◽

Hiba Boumaazi ◽

Sanae Sayagh

Keyword(s):

Case Report ◽

Chronic Myeloid Leukemia ◽

Myeloid Leukemia ◽

Complete Blood Count ◽

Case Reports ◽

Rare Complication ◽

Philadelphia Chromosome ◽

Vitreous Hemorrhage ◽

Interesting Case ◽

Proliferative Retinopathy

Bilateral proliferative retinopathy is a rare complication of chronic myeloid leukemia (CML) as a few case reports have been published to date. In this case report, a 32-year old diabetic female presented with history of bilaterally decreased vision. Ophthalmologic examination showed bilateral proliferative retinopathy (i.e., retinal detachment, vitreous hemorrhage, pre-retinal fibrosis and the presence of bilateral peripheral capillary dropout with multiple retinal sea fan neovascularization) for which panretinal laser photocoagulation and vitrectomy were planned. During the preoperative workup, complete blood count revealed hyperleukocytosis. Later on, the karyotype analysis identified Philadelphia chromosome, confirming the diagnosis of CML. Hence, it was an interesting case where bilateral proliferative retinopathy directed to the diagnosis of CML. Therefore, proliferative retinopathy may be the first presentation of CML.

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An interesting case of chronic myeloid leukemia presenting as B-cell lymphoblastic crisis

Oncolog-Hematolog ro ◽

10.26416/onhe.52.3.2020.3716 ◽

2020 ◽

Vol 3 (1) ◽

pp. 30-32

Author(s):

Andreea Neculcea ◽

Andreea Spînu ◽

Diana Cisleanu ◽

Anca Nicolescu ◽

Cristina Enache ◽

...

Keyword(s):

Chronic Myeloid Leukemia ◽

B Cell ◽

Myeloid Leukemia ◽

Lymphoblastic Leukemia ◽

Interesting Case ◽

Favorable Prognosis ◽

Night Sweats ◽

History Of ◽

Abdominal Quadrant

We present the case of a 46-year-old male patient who came to our emergency department in December 2019 for pain in the left abdominal quadrant. The patient had no fever, night sweats or a history of weight loss. The laboratory tests revealed important leucocytosis and the abdominal ultrasound highlighted a massive splenomegaly. He was hospitalized for further investigations. We performed all the necessary laboratory tests to establish the diagnosis of the patient. Even though the osteomedullar biopsy and the flow cytometry suggested the diagnosis of acute B-cell lymphoblastic leukemia, the fluorescence in situ hybridization exam – the translocation t(9;22) was present in 100% of the analyzed cells – and the detection of BCR-ABL1 b2a2 transcript established the diagnosis of chronic myeloid leukemia, B-cell lymphoblastic crisis. We decided to start the treatment with the GRAAPH 2005 protocol associated with imatinib, and the patient was a candidate for allogeneic transplantation. We chose to present this case because the patient was young, without significant comorbidities, with chronic myeloid leukemia – B-cell lymphoblastic crisis as the initial diagnosis, whose evolution was negative, despite his favorable prognosis.

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