Background:
Type 2 diabetes mellitus (T2DM) is a chronic condition with an
impairing effect on multiple organs. Numerous respiratory disorders have been
observed in patients with T2DM. However, T2DM e ect on pulmonary function is ff
inconclusive.
Aims:
In this study, we investigated the effect of T2DM on respiratory function and
the correlation of glycemic control, diabetes duration and insulin intake.
Methods:
1500 patients were recruited for this study, 560 having T2DM for at least a
year were included in the final data, in addition to 540 healthy volunteers. Forced
expiratory volume in one second (FEV1), forced vital capacity (FVC), forced
expiratory flow at 25-75% (FEF 25-75%), as well as FEV1/FVC ratio values were
measured.
Results:
A two-sample t-test showed that z-scores produced by Al-Qerem et al.’s
equations for FEV1, FVC, and FEF 25-75% were significantly lower for the T2DM
group than the control group (p < 0.01). FEV1/FVC ratio in T2DM group were
significantly higher (p < 0.01). Multiple linear regression analysis found that glycemic
control represented by HbA1c as well as disease duration were negatively associated
with pulmonary function (p < 0.01). However, insulin intake was found to have no
significant correlation with the pulmonary function.
Conclusion:
T2DM was linked to reduced pulmonary function and was consistent
with a restrictive ventilation pattern. HbA1c as well as disease duration were
independent risk factors for reduced pulmonary function.
Assessment of Lung Function by Spirometry and Diffusion Study and Effect of Glycemic Control on Pulmonary Function in Type 2 Diabetes Mellitus Patients of the Eastern India
