scholarly journals Malignant Melanoma Arising in an Ovarian Mature Cystic Teratoma - A Rare Entity

Author(s):  
Ranjini Kudva
2021 ◽  
Vol 22 (5) ◽  
pp. 2436
Author(s):  
Kohei Nakamura ◽  
Eriko Aimono ◽  
Reika Takamatsu ◽  
Shigeki Tanishima ◽  
Tomonari Tohyama ◽  
...  

Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare cases, malignant tumors arise from ovarian mature cystic teratoma. A variety of tumors can arise from mature cystic teratoma, among which primary malignant melanoma (MM), for which no molecular analyses such as genomic sequencing have been reported to date, is exceedingly rare, thereby limiting possible therapeutic options using precision medicine. We used targeted gene sequencing to analyze the status of 160 cancer-related genes in a patient with MM arising from an ovarian mature cystic teratoma (MM-MCT). KRAS amplification and homozygous deletion in PTEN and RB1 were detected in tumor samples collected from the patient. No KRAS amplification has been previously reported in cutaneous MM, indicating that the carcinogenesis of MM-MCT differs from that of primary cutaneous melanomas. A better understanding of the underlying genetic mechanisms will help clarify the carcinogenesis of MM-MCT. In turn, this will enable treatment with novel targeting agents as well as the initial exploration of gene-based precision oncological therapies, which aim to improve treatment outcomes for patients with this disease.


Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S116
Author(s):  
Kianoosh Noori Sarnie ◽  
Afaf Haddad ◽  
Denys Fortune

2014 ◽  
Vol 57 (4) ◽  
pp. 274 ◽  
Author(s):  
Eun-Jeong Choi ◽  
Yu-Jin Koo ◽  
Ji-Hyun Jeon ◽  
Tae-Jin Kim ◽  
Ki-Heon Lee ◽  
...  

2014 ◽  
Vol 4 (1) ◽  
pp. 80 ◽  
Author(s):  
Reetika Sharma ◽  
Biswajeet Biswas ◽  
ShailjaPuri Wahal ◽  
Neelam Sharma ◽  
Vijay Kaushal

2010 ◽  
Vol 53 (9) ◽  
pp. 846 ◽  
Author(s):  
Jei-Won Moon ◽  
Ji Young Kim ◽  
You Jung Shin ◽  
Mi Young Lee ◽  
Hyuck Jae Choi ◽  
...  

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Tushar Subhadarshan Mishra ◽  
Saubhagya Kumar Jena ◽  
Supriya Kumari ◽  
Suvendu Purkait ◽  
Pavithra Ayyanar ◽  
...  

Abstract Background The ovary is the most common site of occurrence of mature cystic teratomas (dermoid cysts). These are the most common ovarian germ cell tumor in the reproductive age group, accounting for 10–20% of all ovarian neoplasms, with a 1–2% risk of malignancy. A cecal dermoid cyst is a rare entity with only ten cases having been reported so far, eight of which could be retrieved as the rest were reported in different languages. None of these cases were managed laparoscopically. Here we present the first case of cecal dermoid managed laparoscopically. Case presentation A 35-year-old nulliparous Indian Hindu woman presented with complaints of on and off abdominal pain for 10 months. The abdominal examination revealed a well-defined mass of about 10 × 5 cm size, palpable in the right iliac fossa. On sonography, it was suggestive of a right-sided ovarian dermoid cyst. The lesion measured 10 × 7 × 5 cm on a contrast-enhanced computed tomogram (CT) scan. It was well defined and hypodense and located in the right lower abdomen. The ovarian tumor markers were normal. On laparoscopy, the uterus, bilateral tubes, and ovaries were found to be healthy. The cyst was seen arising from the right medial wall of the cecum at the ileocecal junction, which was excised laparoscopically. Histopathological study revealed it to be a mature cystic teratoma. Conclusion Ovarian mature cystic teratoma commonly has an indolent course and can present with palpable abdominal mass, pain, or vomiting due to complications like torsion, hemorrhage, or infection. Alternatively, these cysts can be asymptomatic and incidentally detected. Clinicians should be aware of the variety of presentations of dermoid cysts of the bowel as well as mesentery. The exact location of the teratoma eluded us till the laparoscopy despite adequate imaging including a contrast-enhanced CT scan having been performed preoperatively. We are reporting this as it is a rare entity, and this knowledge will help gynecologists and surgeons make an appropriate surgical decision.


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