Two- and Three-Dimensional Sonographic and Color Doppler Techniques for Diagnosis of Polycystic Ovary Syndrome

2012 ◽  
Vol 31 (7) ◽  
pp. 1015-1024 ◽  
Author(s):  
Cesare Battaglia ◽  
Bruno Battaglia ◽  
Elena Morotti ◽  
Roberto Paradisi ◽  
Isabella Zanetti ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Color Doppler ◽  
Three Dimensional ◽  
Ovary Syndrome ◽  
Doppler Techniques

The role of color doppler imaging in the diagnosis of polycystic ovary syndrome

1995 ◽  
Vol 172 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Cesare Battaglia ◽  
Paolo G. Artini ◽  
Gerardo D'Ambrogio ◽  
Alessandro D. Genazzani ◽  
Andrea R. Genazzani
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Color Doppler ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Ovary Syndrome

scholarly journals Endogenous Ovarian Angiogenesis in Polycystic Ovary Syndrome-Like Rats Induced by Low-Frequency Electro-Acupuncture: The CLARITY Three-Dimensional Approach

2018 ◽  
Vol 19 (11) ◽  
pp. 3500 ◽  
Author(s):  
Tong Ma ◽  
Peng Cui ◽  
Xiaoyu Tong ◽  
Wei Hu ◽  
Linus Shao ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Three Dimensional ◽  
Low Frequency ◽  
Corpora Lutea ◽  
Ovary Syndrome ◽  
Follicular Maturation ◽  
Female Wistar Rats ◽  
Follicle Maturation

We sought to determine the role of ovarian vascularity and neo-angiogenesis in the development of mature follicles in polycystic ovary syndrome (PCOS) and to identify any changes induced by low-frequency electro-acupuncture (EA). Twenty-eight 21-day-old female Wistar rats were randomly divided into four groups—Control, Obesity, PCOS-like, and PCOS-like-EA (n = 7/group). Rats in the Obesity group were fed a high-fat diet throughout the experiment. Rats in the PCOS-like and PCOS-like-EA groups were implanted with a sustained-release tube containing 5α-dihydrotestosterone (DHT) beneath the skin of the neck. Rats in the PCOS-like-EA group received low-frequency EA treatment starting at 70 days for 30 min five times a week for four weeks. At the end of the experiment, all rats were euthanized and perfused with hydrogel. The ovaries were collected for clarification and imaging, and ovarian vascularity and neo-angiogenesis were analyzed. Compared with Control and Obesity rats, the ovaries in DHT-induced PCOS-like rats were smaller in size and had fewer mature follicles and corpora lutea. EA increased angiogenesis in the antral follicles of PCOS-like rats, which in turn promoted follicle maturation, ovulation, and CL formation. Therefore, endogenous ovarian angiogenesis plays a very important role in follicular maturation and might be one of the peripheral and direct mechanisms of EA on PCOS.

Ultrasonographic and color Doppler analysis in the treatment of polycystic ovary syndrome

1998 ◽  
Vol 12 (3) ◽  
pp. 180-187 ◽  
Author(s):  
C. Battaglia ◽  
A. D. Genazzani ◽  
P. G. Artini ◽  
M. Salvatori ◽  
S. Giulini ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Color Doppler ◽  
Ovary Syndrome ◽  
Doppler Analysis

Color Doppler analysis in oligo-and amenorrheic women with polycystic ovary syndrome

1997 ◽  
Vol 11 (2) ◽  
pp. 105-110 ◽  
Author(s):  
C. Battaglia ◽  
P. G. Artini ◽  
A. D. Genazzani ◽  
R. Gretnigni ◽  
M. Salvatori ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Color Doppler ◽  
Ovary Syndrome ◽  
Doppler Analysis

scholarly journals Three-Dimensional Genome Interactions Identify Potential Adipocyte Metabolism-Associated Gene STON1 and Immune-Correlated Gene FSHR at the rs13405728 Locus in Polycystic Ovary Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Can-hui Cao ◽  
Ye Wei ◽  
Rang Liu ◽  
Xin-ran Lin ◽  
Jia-qi Luo ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Target Genes ◽  
Polycystic Ovary ◽  
Expression Patterns ◽  
Three Dimensional ◽  
Ovary Syndrome ◽  
Chromosome Conformation ◽  
3D Genome ◽  
Caucasian Women ◽  
Genome Interactions

Backgroundrs13405728 was identified as one of the most prevalent susceptibility loci for polycystic ovary syndrome (PCOS) in Han Chinese and Caucasian women. However, the target genes and potential mechanisms of the rs13405728 locus remain to be determined.MethodsThree-dimensional (3D) genome interactions from the ovary tissue were characterized via high-through chromosome conformation capture (Hi-C) and Capture Hi-C technologies to identify putative targets at the rs13405728 locus. Combined analyses of eQTL, RNA-Seq, DNase-Seq, ChIP-Seq, and sing-cell sequencing were performed to explore the molecular roles of these target genes in PCOS. PCOS-like mice were applied to verify the expression patterns.ResultsGenerally, STON1 and FSHR were identified as potential targets of the rs13405728 locus in 3D genomic interactions with epigenomic regulatory peaks, with STON1 (P=0.0423) and FSHR (P=0.0013) being highly expressed in PCOS patients. STON1 co-expressed genes were associated with metabolic processes (P=0.0008) in adipocytes (P=0.0001), which was validated in the fat tissue (P<0.0001) and ovary (P=0.0035) from fat-diet mice. The immune system process (GO:0002376) was enriched in FSHR co-expressed genes (P=0.0002) and PCOS patients (P=0.0002), with CD4 high expression in PCOS patients (P=0.0316) and PCOS-like models (P=0.0079). Meanwhile, FSHR expression was positively correlated with CD4 expression in PCOS patients (P=0.0252) and PCOS-like models (P=0.0178). Furthermore, androgen receptor (AR) was identified as the common transcription factor for STON1 and FSHR and positively correlated with the expression of STON1 (P=0.039) and FSHR (P=4e-06) in ovary tissues and PCOS-like mice.ConclusionOverall, we identified STON1 and FSHR as potential targets for the rs13405728 locus and their roles in the processes of adipocyte metabolism and CD4 immune expression in PCOS, which provides 3D genomic insight into the pathogenesis of PCOS.

scholarly journals The New Three-dimensional Ultrasound Modes allow a Better Polycystic Ovary Syndrome Ultrasound Diagnosis beyond the Rotterdam Criteria

2015 ◽  
Vol 9 (4) ◽  
pp. 434-445
Author(s):  
Francisco Raga ◽  
Oscar Caballero ◽  
Francisco Bonilla ◽  
Fernando Bonilla-Musoles ◽  
Juan Carlos Castillo
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Three Dimensional ◽  
3D Ultrasound ◽  
Ultrasound Diagnosis ◽  
Ovary Syndrome ◽  
Ovarian Morphology ◽  
Exact Etiology ◽  
Definition Of ◽  
Rotterdam Criteria

ABSTRACT Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting reproductive-aged women. The exact etiology of this condition remains elusive and the definition of the syndrome has undergone several revisions in which ovarian morphology plays a central role. This review describes several and modern three-dimensional (3D) ultrasound modes including: HDliveTM, virtual organ computer-aided analysis (VOCAL), inversion mode, Radiance System ArchitectureTM, for the study of PCOS-related ovarian morphology. This state-of-the-art technology should be employed—when available, in the evaluation of PCOS-related ovarian morphology. How to cite this article Raga F, Bonilla F Jr, Caballero O, Castillo JC, Bonilla-Musoles F. The New Three-dimensional Ultrasound Modes allow a Better Polycystic Ovary Syndrome Ultrasound Diagnosis beyond the Rotterdam Criteria. Donald School J Ultrasound Obstet Gynecol 2015;9(4):434-445.

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