Anxiolytic, Sedative and Hypothermic Effects of Aqueous Leaf Extract of Vernonia amygdalina Del. (Asteraceae) in Albino Mice

2014 ◽  
Vol 4 (18) ◽  
pp. 2210-2225 ◽  
Author(s):  
Imoru Oloruntobi ◽  
Oyemitan Ajayi ◽  
Ilesanmi Rufus
Keyword(s):  
Leaf Extract ◽  
Vernonia Amygdalina ◽  
Aqueous Leaf Extract ◽  
Albino Mice

scholarly journals Vernonia Amygdalina Del (Bitter Leaf) extract ameliorates isoniazid (INH) induced liver injury in Swiss Albino Mice

2018 ◽  
Author(s):  
Gebreselassie Addisu Tilaye ◽  
Muluken Fekadie Zerihun ◽  
Kasaw Adane Chuffa ◽  
Mahelet Arayaselassie ◽  
Daniel Seifu
Keyword(s):  
Liver Injury ◽  
Leaf Extract ◽  
Drug Clearance ◽  
Vernonia Amygdalina ◽  
Drug Induced ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Antitubercular Drugs ◽  
Toxic Injury ◽  
Albino Mice

AbstractLiver plays a central role in the metabolism of drugs. Drug clearance and transformation exposes liver to toxic injury. Antitubercular drugs have been found to be hepatotoxic and potentially lead to drug-induced liver injury. Isoniazid is one of the most hepatotoxic first line antitubercular drugs. Conventional drugs used in the treatment of liver disease are often inadequate and a search for supplementation or alternative drugs for the treatment of hepatic damage is indispensible. Therefore our study aims to investigate the hepatoprotective potential of Vernonia Amygdalina Del (bitter leaf) extract against Isoniazid-induced liver injury in Swiss Albino Mice. Treatment of Mice orally with Vernonia Amygdalina Del extract at dose of 250mg/kg and 375 mg/kg significantly lowered (P<0.05) the serum level of liver enzymes in Isoniazid pretreated mice. The hepatoptotective activity of the extract found to be comparable with the standard drug, Silymarin (100 mg/kg, P.o.). Moreover, treatment with the extract significantly alleviated Isoniazid induced hepatic injury as supported by the photomicrographs of liver section of mice. The data shows aqueous Vernonia Amygdalina Del extract has a very promising hepatoprotective potential against isoniazid-induced liver injury.

scholarly journals Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats

2018 ◽  
Vol 12 (19) ◽  
pp. 231-239
Author(s):  
Madu D. Ibegbu ◽  
Emmanuel J. Nnaemeka ◽  
Ikenna T. Ikele ◽  
Daniel C. Nwachukwu
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Vernonia Amygdalina ◽  
Aqueous Leaf Extract
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