Description of the First Case of Mycobacterium tuberculosis Beijing Strain Isolated in Cameroon

2016 ◽  
Vol 17 (2) ◽  
pp. 1-4
Author(s):  
Francioli Koro ◽  
Joseph Essomba ◽  
Leslie Afi ◽  
Yannick Simo ◽  
Félix Piam ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Beijing Strain ◽  
First Case

Mycobacterium tuberculosis Infection in a Domesticated Korean Wild Boar (Sus scrofa coreanus)

2017 ◽  
Vol 80 (6) ◽  
pp. 1009-1014 ◽  
Author(s):  
Min-Goo Seo ◽  
In-Ohk Ouh ◽  
Munki Kim ◽  
Jienny Lee ◽  
Young-Hoan Kim ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Wild Boar ◽  
Sus Scrofa ◽  
Control Strategies ◽  
Rpob Gene ◽  
Tuberculosis Infection ◽  
Primate Species ◽  
Monitoring And Control ◽  
Mycobacterium Tuberculosis Infection ◽  
First Case

ABSTRACTTuberculosis, a chronic progressive disease, has been reported in bovine, swine, and primate species. Here, we report the first case of Mycobacterium tuberculosis infection in a Korean wild boar (Sus scrofa coreanus). The owners this domesticated boar brought it to the Gyeongbuk Veterinary Service Laboratory in Korea after it was found dead and severely emaciated. Demarcated yellowish white nodules were found around the larynx and retropharyngeal lymph node during necropsy. The lungs had diffuse fibrinous pleuritis, severe congestion, and scattered nodules. More nodules were found in the spleen. Tuberculosis is characterized by massive macrophage infiltration and central caseous necrosis; both characteristics were found in the lungs. Histopathologic examination revealed that the alveolar lumen had marked fibrosis and exudates. Examination of the fluid revealed extensive macrophage permeation. To confirm a Mycobacterium infection, PCR was performed using two primer sets specific to the rpoB gene of Mycobacterium; Mycobacterium was detected in the lungs and spleen. To identify the species of Mycobacterium, immunohistochemical evaluation was performed using antibodies against Mycobacterium tuberculosis and Mycobacterium bovis. The results revealed immunoreactivity against M. tuberculosis but not against M. bovis. The consumption of undercooked or raw meat from game animals may expose humans and other animals to sylvatic infection. Consequently, Koreans who ingest wild boar may be at risk of a tuberculosis infection. To reduce the risk of foodborne infection and maintain public health, continuous monitoring and control strategies are required.

scholarly journals Prurigo nodularis due to Mycobacterium tuberculosis

2009 ◽  
Vol 58 (12) ◽  
pp. 1649-1651 ◽  
Author(s):  
Laura Saporito ◽  
Ada Maria Florena ◽  
Claudia Colomba ◽  
Diego Pampinella ◽  
Paola Di Carlo
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Unknown Origin ◽  
Mycobacterial Infection ◽  
Skin Lesions ◽  
Pcr Analysis ◽  
Prurigo Nodularis ◽  
First Case ◽  
Chronic Skin ◽  
First Time ◽  
Time Culture

Prurigo nodularis (PN) is a rare chronic skin disorder of unknown origin. Here we describe what is believed to be the first case of PN associated with tuberculosis. For the first time, culture and PCR analysis of skin biopsy confirmed the presence of Mycobacterium tuberculosis complex in PN skin lesions. The pruritus and skin lesions resolved following antitubercular therapy. Our case provides further evidence in favour of a link between PN and mycobacterial infection.

First case of Mycobacterium tuberculosis transmission by heart transplantation from donor to recipient

2013 ◽  
Vol 303 (8) ◽  
pp. 449-451 ◽  
Author(s):  
Jan Weile ◽  
Holm Eickmeyer ◽  
Jens Dreier ◽  
Michael Liebke ◽  
Uwe Fuchs ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Heart Transplantation ◽  
Tuberculosis Transmission ◽  
First Case

scholarly journals First reported case of fatal tuberculosis in a wild African elephant with past human–wildlife contact

2013 ◽  
Vol 141 (7) ◽  
pp. 1476-1480 ◽  
Author(s):  
V. OBANDA ◽  
J. POGHON ◽  
M. YONGO ◽  
I. MULEI ◽  
M. NGOTHO ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
National Park ◽  
African Elephant ◽  
Post Mortem ◽  
African Elephants ◽  
First Case ◽  
In The Wild

SUMMARYTuberculosis is emerging/re-emerging in captive elephant populations, where it causes morbidity and deaths, although no case of TB in wild African elephants has been reported. In this paper we report the first case of fatal TB in an African elephant in the wild. The infection with Mycobacterium tuberculosis was confirmed by post-mortem and histological examinations of a female sub-adult elephant aged >12 years that died in Tsavo East National Park, Kenya, while under treatment. This case is unique in that during its lifetime the elephant had contact with both humans and wild elephants. The source of the infection was unclear because the elephant could have acquired the infection in the orphanage or in the wild. However, our results show that wild elephants can maintain human TB in the wild and that the infection can be fatal.

scholarly journals Pre-Multidrug-Resistant Mycobacterium tuberculosis Beijing Strain Associated with Disseminated Tuberculosis in a Pet Dog

2013 ◽  
Vol 52 (1) ◽  
pp. 354-356 ◽  
Author(s):  
A. Botelho ◽  
J. Perdigao ◽  
A. Canto ◽  
T. Albuquerque ◽  
N. Leal ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistant ◽  
Beijing Strain ◽  
Disseminated Tuberculosis

scholarly journals The role of Mycobacterium tuberculosis complex species on apoptosis and necroptosis state of macrophages derived from active pulmonary tuberculosis patients

2020 ◽  
Author(s):  
Budi Yanti ◽  
Mulyadi Mulyadi ◽  
Muhammad Amin ◽  
Harapan Harapan ◽  
Ni Made Mertaniasih ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Tuberculosis Complex ◽  
Lung Damage ◽  
Beijing Strain ◽  
Death Domain ◽  
Tuberculosis Complex ◽  
Complex Species ◽  
Pulmonary Tb ◽  
Apoptosis Level

Abstract Objective: The role of Mycobacterium tuberculosis complex (MTBC) species in tuberculosis (TB) infection in human is still questioned. The aim of this study was to determine whether M. tuberculosis and M. bovis is associated with apoptosis and necroptosis by measuring the expression of specific signaling pathways components (Fas-associated protein with death domain (FADD) and receptor interacting protein 3 (RIP3)), and the level of apoptosis. Results: We recruited 30 patients with pulmonary TB; 24 patients were infected with M. tuberculosis Beijing strain and six patients with M. bovis BCG strain. M. tuberculosis-infected patients were more likely to have severe lung damage compared to those infected with M. bovis (odds ratio [OR]: 7.60; 95% confidence interval [CI]: 1.07-54.09). M. tuberculosis infection was associated with lower expression of FADD and lower apoptosis level of macrophages compared to M. bovis. No significant different of RIP3 between MTBC species groups. In conclusion, M. tuberculosis Beijing strain was associated with severe pulmonary damage, inhibited FADD expression and reduced apoptosis level of macrophages derived from pulmonary TB patients. This suggests that the M. tuberculosis Beijing strain is potentially to be used as determinant of disease progressivity and tissue damage in TB cases.

Bacterial population kinetics in heteroresistant Mycobacterium tuberculosis harbouring rare resistance-conferring mutations in gyrA and rpoB imply an epistatic interaction of mutations in a pre-XDR-TB patient

2020 ◽  
Vol 75 (7) ◽  
pp. 1722-1725 ◽  
Author(s):  
Shiomi Yoshida ◽  
Tomotada Iwamoto ◽  
Kentaro Arikawa ◽  
Tsuyoshi Sekizuka ◽  
Makoto Kuroda ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Epistatic Interaction ◽  
High Probability ◽  
Bacterial Population ◽  
Compensatory Mutation ◽  
Population Kinetics ◽  
Rare Mutations ◽  
First Case ◽  
Kinetics Of

Abstract Objectives Bacterial population kinetics of strains harbouring drug resistance-conferring mutations within a patient often show cryptic resistance in clinical practice. We report a case that showed emergence and dominance of Mycobacterium tuberculosis with uncommon rpoB and gyrA mutations, followed by an rpoC compensatory mutation, during treatment. Methods A pre-XDR-TB patient showed heteroresistance to rifampicin and levofloxacin during treatment as a result of intermittent self-cessation. WGS was applied to investigate intra-host strain composition using five pairs of isolates from sputum samples. Results The subclone in this study possessed rare mutations conferring resistance to rifampicin (rpoB V170F) and levofloxacin (gyrA S91P) and it rapidly outcompeted other subclones during treatment that included levofloxacin but not rifampicin (<7 days). The high-probability compensatory mutation rpoC V483A also emerged and became dominant subsequent to the rpoB V170F mutation. Conclusions To the best of our knowledge, this is the first case showing the emergence of such a rare variant that dominated the population within a patient during treatment of TB.

scholarly journals A Recently Evolved Sublineage of the Mycobacterium tuberculosis Beijing Strain Family Is Associated with an Increased Ability to Spread and Cause Disease

2007 ◽  
Vol 45 (5) ◽  
pp. 1483-1490 ◽  
Author(s):  
M. Hanekom ◽  
G. D. van der Spuy ◽  
E. Streicher ◽  
S. L. Ndabambi ◽  
C. R. E. McEvoy ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Beijing Strain ◽  
Strain Family

First case of multidrug-resistant tuberculosis caused by a rare “Beijing-like” genotype of Mycobacterium tuberculosis in Bogotá, Colombia

2010 ◽  
Vol 10 (5) ◽  
pp. 678-681 ◽  
Author(s):  
Martha I. Murcia ◽  
Marina Manotas ◽  
Yesica J. Jiménez ◽  
Johana Hernández ◽  
Maria Irene Cerezo Cortès ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Multidrug Resistant ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
First Case

scholarly journals Effect of serial subculturing on the genetic composition and cytotoxicactivity of Mycobacterium tuberculosis

2010 ◽  
Vol 59 (4) ◽  
pp. 384-391 ◽  
Author(s):  
C. A. Molina-Torres ◽  
J. Castro-Garza ◽  
J. Ocampo-Candiani ◽  
M. Monot ◽  
S. T. Cole ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Phospholipase C ◽  
Rabies Virus ◽  
Microarray Analysis ◽  
Mycobacterium Bovis ◽  
Cytotoxic Effect ◽  
Beijing Strain ◽  
Genetic Composition ◽  
Genomic Changes ◽  
Micro Organisms

Continuous subculture has been observed to produce changes in the virulenceof micro-organisms, e.g. rabies virus, poliovirus and Mycobacterium bovis BCG. The latter has been used as a vaccine for tuberculosis for thelast 100 years; however, in some instances its efficacy has been observedto be very low. In order to determine whether similar changes can be producedin Mycobacterium tuberculosis, we selected four isolates, M.tuberculosis H37Rv, a Beijing strain (DR-689), and two moreisolates with deletion of the phospholipase C locus (plcA-plcB-plcC), and subjected them to serial culturing on Middlebrook 7H9 medium,with or without ox bile. After 100 passages, we performed RFLP-IS6110 analysis to determine whether genomic changes were produced. We alsochecked their genomic composition by microarray analysis. Changes in virulencewere studied by measuring the cytotoxic effect of parental and subculturedisolates on a THP-1 macrophage monolayer. The most visible change was thechange of position of an IS6110 band of ∼1400 bp to ∼1600 bpin the Beijing isolate subcultured in the ox bile medium. Analysis by microarrayand PCR confirmation did not reveal any genomic changes. Cytotoxic activitywas decreased in the isolates at levels close to that of BCG, and more consistentlyin those subcultured in the presence of ox bile.

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