Histone Deacetylase Inhibition Restores Expression of Hypoxia-Inducible Protein NDRG1 in Pancreatic Cancer: An Advance Study

2021 ◽  
pp. 1-14
Author(s):  
Céline Tiffon
Keyword(s):  
Pancreatic Cancer ◽  
Histone Deacetylase ◽  
Advance Study ◽  
Histone Deacetylase Inhibition ◽  
Inducible Protein

Su1796 Histone Deacetylase Inhibition (HDAC) by Vorinostat Sensitizes Pancreatic Cancer Cells to TRAIL Induced Cell Death

2013 ◽  
Vol 144 (5) ◽  
pp. S-1088
Author(s):  
Rohit Chugh ◽  
Vikas Dudeja ◽  
Osama Alsaied ◽  
Sulagna Banerjee ◽  
Veena Sangwan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibition ◽  
Pancreatic Cancer Cells

scholarly journals Synergistic anti-cancer effect of histone deacetylase inhibition and blockade of the glycolytic pathway

2018 ◽  
Vol 29 ◽  
pp. viii646
Author(s):  
S.Y. Kim ◽  
Y.S. Lee ◽  
H. Chang ◽  
H.-S. Chang ◽  
C.S. Park
Keyword(s):  
Histone Deacetylase ◽  
Glycolytic Pathway ◽  
Histone Deacetylase Inhibition ◽  
Anti Cancer

scholarly journals The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses

2012 ◽  
Vol 287 (49) ◽  
pp. 40924-40937 ◽  
Author(s):  
Inga Bauer ◽  
Alessia Grozio ◽  
Denise Lasigliè ◽  
Giovanna Basile ◽  
Laura Sturla ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Cytokine Production ◽  
Pancreatic Cancer Cells ◽  
And Migration

scholarly journals Genome-Wide STAT3 Binding Analysis after Histone Deacetylase Inhibition Reveals Novel Target Genes in Dendritic Cells

2016 ◽  
Vol 9 (2) ◽  
pp. 126-144 ◽  
Author(s):  
Yaping Sun ◽  
Matthew Iyer ◽  
Richard McEachin ◽  
Meng Zhao ◽  
Yi-Mi Wu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dendritic Cells ◽  
Histone Deacetylase ◽  
Antigen Processing ◽  
Target Genes ◽  
Hdac Inhibition ◽  
Histone Deacetylase Inhibition ◽  
Immune Effector ◽  
Chip Sequencing ◽  
Genome Wide

STAT3 is a master transcriptional regulator that plays an important role in the induction of both immune activation and immune tolerance in dendritic cells (DCs). The transcriptional targets of STAT3 in promoting DC activation are becoming increasingly understood; however, the mechanisms underpinning its role in causing DC suppression remain largely unknown. To determine the functional gene targets of STAT3, we compared the genome-wide binding of STAT3 using ChIP sequencing coupled with gene expression microarrays to determine STAT3-dependent gene regulation in DCs after histone deacetylase (HDAC) inhibition. HDAC inhibition boosted the ability of STAT3 to bind to distinct DNA targets and regulate gene expression. Among the top 500 STAT3 binding sites, the frequency of canonical motifs was significantly higher than that of noncanonical motifs. Functional analysis revealed that after treatment with an HDAC inhibitor, the upregulated STAT3 target genes were those that were primarily the negative regulators of proinflammatory cytokines and those in the IL-10 signaling pathway. The downregulated STAT3-dependent targets were those involved in immune effector processes and antigen processing/presentation. The expression and functional relevance of these genes were validated. Specifically, functional studies confirmed that the upregulation of IL-10Ra by STAT3 contributed to the suppressive function of DCs following HDAC inhibition.

scholarly journals Histone deacetylase inhibition induces odor preference memory extension and maintains enhanced AMPA receptor expression in the rat pup model

2017 ◽  
Vol 24 (10) ◽  
pp. 543-551 ◽  
Author(s):  
Sriya Bhattacharya ◽  
Bandhan Mukherjee ◽  
Jules J.E. Doré ◽  
Qi Yuan ◽  
Carolyn W. Harley ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Ampa Receptor ◽  
Receptor Expression ◽  
Odor Preference ◽  
Histone Deacetylase Inhibition ◽  
Rat Pup
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