Potential Hazards of Ethanolic Extract of Garcinia kola on the Testes of Adult Male Wistar Rats

2019 ◽  
Vol 19 (3) ◽  
pp. 1-6
Author(s):  
E. O. Nweke ◽  
J. K. Opara ◽  
I. J. Okafor
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Garcinia Kola ◽  
Male Wistar Rats

Efficacy of Garcinia kola Seed Ethanolic Extract on Haematological Parameters in Male Wistar Rats

2015 ◽  
Vol 3 (1) ◽  
pp. 10-23 ◽  
Author(s):  
Denen Atsukwei ◽  
Eze Daniel ◽  
Samuel Odeh ◽  
Moses Adams ◽  
Ibrahim Malgwi ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Haematological Parameters ◽  
Garcinia Kola ◽  
Male Wistar Rats

scholarly journals Evaluation of the Effects of Ethanolic Extract of Sesamum Indicum Seeds on Sperm Morphology and Viability in KetoconazoleInduced Testicular Damage in Male Wistar Rats

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Yusuf MK
Keyword(s):  
Body Weight ◽  
Adult Male ◽  
Normal Saline ◽  
Wistar Rats ◽  
Sperm Morphology ◽  
Ethanolic Extract ◽  
Sesamum Indicum ◽  
Testicular Damage ◽  
Male Wistar Rats ◽  
Group 2

Aim: The study was aimed at evaluating the effects of ethanolic extract of Sesamum indicum seeds on sperm morphology and viability in ketoconazole induced testicular damage in Wistar rats. Methods: Forty eight adult male Wistar rats were divided into eight Groups of six rats each. Groups 1,2,3,4,5,6,7 and 8 were administered 1ml of normal saline, 100 mg /kg body weight (bwt) of Ketoconazole only, 500 mg/kg bwt of ethanolic extract of sesamum indicum (EESI) seeds then100 mg/kg bwt of Ketoconazole, 100 mg/kg bwt of Ketoconazole then 250 mg /kg body weight of EESI seeds,100 mg/kg bwt of Ketoconazole then 500 mg/kg bwt of EESI, 100 mg/kg body weight of Ketoconazole then 0.36 mg/kg body weight of Mesterolone, 0.36 mg/kg body weight of Mesterolone, 500 mg/kg body weight of EESI respectively. All administrations were carried out orally once per day. The sperm smears were collected for semen analyses. Result: A significant increase in the abnormalities of sperm morphology and viability respectively were noted in the group administered ketoconazole alone (Group 2) compared with other experimental Groups (P ≤ 0.05). Conclusions: The administration of ethanolic extract of Sesamum indicum appeared to have minimized the damages and sperm deaths caused by ketoconazole which may be due to its androgenic properties.

scholarly journals THE EFFECT OF ZINGIBER OFFICINALE (GINGER) ROOT ETHANOLIC EXTRACT ON THE SEMEN CHARACTERISTICS OF ADULT MALE WISTAR RATS

2018 ◽  
Vol 6 (3.2) ◽  
pp. 5481-5487 ◽  
Author(s):  
Yaw Otchere Donkor ◽  
◽  
Chrissie Stansie Abaidoo ◽  
Joshua Tetteh ◽  
Nancy Darkoa Darko ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Zingiber Officinale ◽  
Semen Characteristics ◽  
Male Wistar Rats

scholarly journals Nephroprotective Effect of Costus (Saussurea costus) Ethanolic Extract on Oxaliplatin®-induced Nephrotoxicity in Adult Male Wistar Rats

2021 ◽  
Vol 24 (8) ◽  
pp. 830-839
Author(s):  
Mahmoud Ashry ◽  
Doaa Galal El-S ◽  
Dalia A. Gaber ◽  
Mohamed A. Mustafa ◽  
Khaled G. Abdel-Wahh
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Male Wistar Rats ◽  
Nephroprotective Effect

scholarly journals EVALUATION OF HEPATOPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF PHYSALI IXOCARPA AGAINST RIFAMPICIN-ISONIAZID INDUCED HEPATOTOXICITY IN WISTAR RATS

2020 ◽  
Vol 11 (10) ◽  
pp. 17-22
Author(s):  
N Delhiraj ◽  
M K Jaganathan ◽  
A R Vijayakumar
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Histopathological Studies ◽  
Tuberculosis Therapy

The liver is the primary organ that metabolizes the majority of the drug. Toxicity caused by these drugs to the liver is called hepatotoxicity. Hepatotoxicity is a major concern in tuberculosis therapy, especially Rifampicin - Isoniazid (R-H). Studies showed that these drugs induce oxidative stress in the liver. This study attempts to determine whether the ethanolic extract of Physalis ixocarpa (EEPI) protects against R-H induced hepatotoxicity in adult male Wistar rats. Adult male Wistar rats were divided into five groups (each group n=6 animals). Group I, control treated with normal saline (5ml/kg, b/w, p.o.). Group II, Hepatotoxicity induced by combination of R-H (each 50mg/kg, i.p.) administered up to 14 days. Group III and IV, EEPI (100 mg/kg & 200 mg/kg, b/w) were administered orally one hour before the R-H inducing agent up to 14 days. Group V, Silymarin (25 mg /kg, b/w., p.o.) was served as standard. After 14th days animals were allowed fast overnight and blood was collected through orbital puncture and animal was sacrificed then liver tissue was collected for biochemical analysis and histopathological studies. Our results show a significant reduction in the level of alkaline phosphate (ALP), alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin. Treatment with EEPI also showed a significant increase in the activity of antioxidant enzymes and decreased levels of malondialdehyde (MDA) in the liver. EEPI also reduced the macrovesicular steatosis and ballooning caused by the R-H. The present study demonstrates that administration of ethanolic extract of Physalis ixocarpa ameliorating hepatoprotective activity as evidenced by the biochemical and histopathological parameters.

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