Garcinia Kola Improves Adrenal and Testicular Tissues Oxidations Via Enhancing Antioxidants Activities in Normal Adult Male Wistar Rats

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

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Garcinia Kola Seeds: Is the Aqueous Extract a True Aphrodisiac in Male Wistar Rats?

African Journal of Traditional Complementary and Alternative Medicines ◽

10.4314/ajtcam.v9i4.9 ◽

2012 ◽

Vol 9 (4) ◽

Cited By ~ 3

Author(s):

MT Yakubu ◽

AL Quadri

Keyword(s):

Aqueous Extract ◽

Wistar Rats ◽

Garcinia Kola ◽

Male Wistar Rats

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Anti‐Fertility Effects of Amlodipine in Adult Male Wistar Rats

The FASEB Journal ◽

10.1096/fasebj.25.1_supplement.873.3 ◽

2011 ◽

Vol 25 (S1) ◽

Author(s):

Adelaja Abdulazeez Akinlolu ◽

Olaide Ghazali ◽

Adebayo Kehinde Adefule

Keyword(s):

Adult Male ◽

Wistar Rats ◽

Male Wistar Rats

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Azathioprine and Methotrexate impaired the morphology and functions of the testes in adult wistar rats

Journal of Morphological Sciences ◽

10.4322/jms.057513 ◽

2014 ◽

Vol 31 (02) ◽

pp. 075-081

Author(s):

A. Akinlolu ◽

O. Akinola ◽

P. Khobe ◽

K. Obasi ◽

O. Dada

Keyword(s):

Adult Male ◽

Wistar Rats ◽

Follicle Stimulating Hormone ◽

Physiological Saline ◽

Seminiferous Tubules ◽

Control Group ◽

Connective Tissues ◽

Group I ◽

Male Wistar Rats ◽

Dose Dependent

Abstract Introduction: AAzathioprine and Methotrexate are both used in the treatment of cancer; and are classified as cytotoxic drugs with reported adverse effects such as oxidative damage to the DNA/RNA, the testes and sperm cells. This study, therefore, tested the hypothesis that AAzathioprine and Methotrexate administrations impair the morphology and functions of the testes in adult male wistar rats. Methods: AAzathioprine (50-150mg per day) and Methotrexate (2.5mg per week) are used in the treatment of cancer in adult Man. We tested the hypothesis that AAzathioprine and Methotrexate impair the morphology and functions of testes in rats. Forty adult male wistar rats (150-230g) were employed in the study: Control Group I received physiological saline while Experimental Groups II - V received oral administrations of 5mg/kg/bodyweight of AAzathioprine per day, 15mg/kg/bodyweight of AAzathioprine per day, 8mg/kg/bodyweight of Methotrexate per week and 20mg/kg/bodyweight of Methotrexate per week respectively for 35 days. Results: Histological examinations of the testes of rats of Groups II - V showed dose-dependent morphological anomalies such as fewer collagen ibers of connective tissues, disrupted seminiferous tubules and scanty spermatozoa when compared to rats of Group I. Statistical analyses showed dose-dependent elevated levels (P≤0.05) of superoxide dismutase and malondialdehyde in testes homogenates of rats of Groups II - V when compared to rats of Group I. This implied increased oxidative stress in rats of Groups II - V. Evaluations of Follicle Stimulating Hormone and Testosterone showed dose-dependent significantly elevated levels (P≤0.05) in rats of Groups II - V when compared to rats of Group I. Conclusions: Our findings are consistent with the stated hypothesis.

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Avoidance memory requires CaMKII activity to persist after recall

Molecular Brain ◽

10.1186/s13041-021-00877-5 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Andressa Radiske ◽

Maria Carolina Gonzalez ◽

Janine I. Rossato ◽

Gênedy Apolinário ◽

João R. de Oliveira ◽

...

Keyword(s):

Protein Kinase ◽

Adult Male ◽

Wistar Rats ◽

Memory Reconsolidation ◽

Memory Processing ◽

Conflicting Information ◽

Male Wistar Rats ◽

Avoidance Memory ◽

Avoidance Responses

AbstractAvoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.

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