scholarly journals Effect of Fresh Frozen Plasma Transfusion Inpatients with Coagulation Abnormalities

2021 ◽  
pp. 22-26
Author(s):  
S. Nagulan ◽  
A. Hariharan ◽  
I. Sureshkumar ◽  
S. Chitra
Keyword(s):  
Retrospective Study ◽  
Medical Records ◽  
Patient Population ◽  
Fresh Frozen Plasma ◽  
Transfusion Practice ◽  
Transfusion Medicine ◽  
Plasma Transfusion ◽  
Coagulation Abnormalities ◽  
Fresh Frozen ◽  
Frozen Plasma

Aim: To study the efficacy of Fresh Frozen Plasma (FFP) transfusion practice in patients with coagulation abnormalities varies in clinical practice. Study Design: A retrospective study. Place and Duration of Study: This study was conducted in Department of Transfusion Medicine, SMCH, Chennai, between the period of 2019-2020. Methodology: The medical records of each patient receiving FFP transfusions that occurred in patients with coagulation abnormalities were reviewed and the data were collected based on pre-and post transfusion PT (>12 sec), APTT (>70sec) and INR (>1.5) and then analysed statistically. Patients with normal coagulation parameters were excluded from study. Results: A total of 1259 units of fresh frozen plasma were transfused to 315 patients between the year 2019-2020. Of the 1259 units transfused 1133 units where transfused to 283 patients with coagulation abnormalities. Apparently 32 patients were excluded from the study as they had normal coagulation profile. Among 251 patients, 37 patients PT were greater than 12 seconds before FFP transfusion out of which the PT was corrected for 14 patients (37.8%) after FFP transfusion. In 228 patients APTT was greater than 70 seconds before FFP transfusion, out of which APTT was corrected in 18 patients (8%) after transfusion. INR values for all 251 patients were greater than1.5 before FFP transfusion, out of which INR was corrected in 84 patients (29%) after transfusion. Conclusion: We conclude that FFP transfusions in patients with coagulation abnormalities maycorrects the defect only in less percentage of patient population, as in our study it corrects only an average of 31% of patient population.

A retrospective study of the effect of fibrinogen levels during fresh frozen plasma transfusion in patients with traumatic brain injury

2019 ◽  
Vol 161 (9) ◽  
pp. 1943-1953 ◽  
Author(s):  
Ryuta Nakae ◽  
Shoji Yokobori ◽  
Yasuhiro Takayama ◽  
Takahiro Kanaya ◽  
Yu Fujiki ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Retrospective Study ◽  
Brain Injury ◽  
Fresh Frozen Plasma ◽  
Plasma Transfusion ◽  
Fresh Frozen ◽  
Frozen Plasma

Ongoing Variability in Transfusion Practices in Cardiac Surgery Despite Established Guidelines.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 947-947 ◽  
Author(s):  
Stephanie A. Snyder-Ramos ◽  
Patrick Moehnle ◽  
Yi-Shin Weng ◽  
Bernd W. Boettiger ◽  
Alexander Kulier ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Evaluation System ◽  
Blood Product ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Fresh Frozen Plasma ◽  
Transfusion Practice ◽  
Cabg Surgery ◽  
Fresh Frozen ◽  
Frozen Plasma

Abstract Although blood utilization has been under considerable scrutiny for the past two decades, particularly for surgery, the international evolution of standards remains unknown. Therefore, the objective of this study was to compare the perioperative transfusion of blood components in patients undergoing coronary artery bypass graft (CABG) surgery in different countries. Transfusion practice was investigated prospectively among 16 countries (70 centers). Five-thousand sixty-five (5,065) randomly selected cardiac surgery patients in the Multicenter Study of Perioperative Ischemia Epidemiology II (EPI II) Study were evaluated. Utilization of red blood cells, fresh frozen plasma, and platelets was assessed by day, prior to, during and after surgery until hospital discharge. Intraoperative red blood cell (RBC) transfusion varied from 9 percent to 100 percent among the 16 countries, and 25 percent to 87 percent postoperatively (percent of transfused patients). Similarly, transfusion of fresh frozen plasma (FFP) varied from 0 percent to 98 percent intraoperatively and 3 percent to 95 percent postoperatively, and platelet (PL) transfusion from 0 percent to 51 percent and 0 percent to 39 percent, respectively. An analysis of the EuroSCORE (an internationally validated risk evaluation system for cardiac surgery) risk indices of the countries with the highest and lowest frequencies of use or amounts of each of type blood product failed to demonstrate a correlation between EuroSCOREs and maximum vs minimum frequency of use or amount of blood product administered. Establishment of international guidelines for utilization of blood products in CABG surgery appears necessary.

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