scholarly journals Comparative Evaluation of Open Flap Debridement Therapy with Two Different Types of Platelet Concentrates, T-PRF and L-PRF as Adjuncts- A Systematic Review

2021 ◽  
pp. 263-271
Author(s):  
Gowri Pendyala ◽  
Ekta Srivastava ◽  
Babita Pawar ◽  
Satish Manthena ◽  
Swati Pustake ◽  
...  
Keyword(s):  
Bone Defect ◽  
Gold Standard ◽  
Comparative Evaluation ◽  
Scaling And Root Planing ◽  
Platelet Concentrates ◽  
Intrabony Defects ◽  
Platelet Rich Fibrin ◽  
Different Types ◽  
Ebsco Host ◽  
Open Flap Debridement

Conventional Periodontal therapy such as scaling and root planing and open flap debridement aims to halt the inflammation process and promotes repair of disease-related defects. Current regenerative procedures offers a limited potential toward attaining a complete periodontal restoration and none is considered a gold standard in the treatment of intrabony defects. This study was done to compare the efficiency of Titanium-Platelet Rich Fibrin and Leukocyte-Platelet Rich Fibrin as adjuncts to Open Flap Debridement  therapy to treat intra-bony periodontal defects. A search was conducted through PubMed and various other databases such as Cochrane, Google Scholar and EBSCO Host , under the key words, OFD , T-PRF,L-PRF, Clinical Outcomes, Comparison and  Randomised Contolled Trials. Six relevant articles were selected for analysis. Compared to non-platelet concentrates, L-PRFproves to be the better adjunct to open flap debridement therapy. When compared to T-PRF, however, L-PRF has comparatively inferior properties of bone defect resolution and fill.We can conclude that T-PRF has better properties, greater bone defect fill and defect resolution as compared to L-PRF.

scholarly journals Plasma Rich in Growth Factors in the Treatment of Endodontic Periapical Lesions in Adult Patients: A Narrative Review

2021 ◽  
Vol 14 (10) ◽  
pp. 1041
Author(s):  
Agata Zoltowska ◽  
Katarzyna Machut ◽  
Elzbieta Pawlowska ◽  
Marcin Derwich
Keyword(s):  
Growth Factors ◽  
Tissue Regeneration ◽  
Adult Patients ◽  
Application Site ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin ◽  
Periapical Lesions ◽  
Pubmed Database ◽  
Proliferation And Differentiation ◽  
Different Types

Platelet concentrates have been widely used in regenerative medicine, including endodontics. The aim of this manuscript was to assess critically the efficacy of PRF in the treatment of endodontic periapical lesions in adult patients on the basis of the literature. The PICO approach was used to properly develop literature search strategies. The PubMed database was analyzed with the keywords: “((PRP) OR (PRF) OR (PRGF) OR (CGF)) AND (endodontic) AND ((treatment) OR (therapy))”. After screening of 155 results, 14 articles were included in this review. Different types of platelet concentrates are able to stimulate the processes of proliferation and differentiation of mesenchymal stem cells. Platelet rich fibrin (PRF) releases growth factors for at least 7 days at the application site. Growth factors and released cytokines stimulate the activity of osteoblasts. Moreover, the release of growth factors accelerates tissue regeneration by increasing the migration of fibroblasts. It was not possible to assess the efficacy of PRF supplementation in the treatment of endodontic periapical lesions in permanent, mature teeth with closed apexes, due to the lack of well-designed scientific research. Further studies are needed to analyze the effect of PRF on the healing processes in the periapical region.

scholarly journals Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis

2015 ◽  
Vol 09 (01) ◽  
pp. 100-108 ◽  
Author(s):  
Ashish Mathur ◽  
Vivek Kumar Bains ◽  
Vivek Gupta ◽  
Rajesh Jhingran ◽  
G. P. Singh
Keyword(s):  
Bone Graft ◽  
Primary Objective ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Intrabony Defects ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Probing Pocket Depth ◽  
Bivariate Correlation ◽  
Open Flap Debridement

ABSTRACT Objective: The primary objective of this study was to compare clinically and radiographically the efficacy of autologous platelet rich fibrin (PRF) and autogenous bone graft (ABG) obtained using bone scrapper in the treatment of intrabony periodontal defects. Materials and Methods: Thirty-eight intrabony defects (IBDs) were treated with either open flap debridement (OFD) with PRF or OFD with ABG. Clinical parameters were recorded at baseline and 6 months postoperatively. The defect-fill and defect resolution at baseline and 6 months were calculated radiographically (intraoral periapical radiographs [IOPA] and orthopantomogram [OPG]). Results: Significant probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, defect fill and defect resolution at both PRF and ABG treated sites with OFD was observed. However, inter-group comparison was non-significant (P > 0.05). The bivariate correlation results revealed that any of the two radiographic techniques (IOPA and OPG) can be used for analysis of the regenerative therapy in IBDs. Conclusion: The use of either PRF or ABG were effective in the treatment of three wall IBDs with an uneventful healing of the sites.

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