Granulocyte-Colony Stimulating Factor–Producing Gallbladder Carcinoma

Abstract A 78-year-old man was admitted to our hospital with right upper abdominal pain and fever. His general condition was poor. The laboratory data showed severe inflammatory reactions. Computed tomography revealed an irregular tumor in the gallbladder. 18F-fluorodeoxy-glucose positron emission tomography (FDG-PET) showed high uptake by the tumor, with diffuse uptake in the spine. Based on the elevated leukocyte count and FDG-PET findings, a granulocyte-colony stimulating factor (G-CSF)–producing tumor was diagnosed (G-CSF 120 pg/mL). We performed cholecystectomy with central bisegmentectomy of the liver, lymph node dissection and right hemicolectomy. Histologically, the tumor was an adenosquamous cell carcinoma of the gallbladder. Immunohistochemical staining of the tumor cells was positive for G-CSF. Postoperatively, the general condition of the patient was improved. The fever subsided, the leukocyte count and serum G-CSF level normalized, and FDG-PET showed no uptake in the spine postoperatively. The patient showed no signs of recurrence at 27 months after undergoing surgery. FDG-PET is a useful method for diagnosing G-CSF–producing gallbladder carcinoma. Aggressive curative resection for G-CSF–producing gallbladder carcinoma may improve patients' general condition and prognosis.

Download Full-text

Granulocyte Colony-Stimulating Factor–Producing Cholangiocellular Carcinoma

International Surgery ◽

10.9738/intsurg-d-13-00183.1 ◽

2015 ◽

Vol 100 (1) ◽

pp. 123-127 ◽

Cited By ~ 7

Author(s):

Kazuhiro Suzumura ◽

Yuji Iimuro ◽

Tadamichi Hirano ◽

Yasukane Asano ◽

Nobukazu Kuroda ◽

...

Keyword(s):

Lymph Nodes ◽

Fdg Pet ◽

Leukocyte Count ◽

Laboratory Data ◽

Cholangiocellular Carcinoma ◽

Remnant Liver ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Inflammatory Reactions ◽

Stimulating Factor

Abstract A 61-year-old female was admitted to our hospital with epigastric pain and fever. The laboratory data showed severe inflammatory reactions. Computed tomography revealed an irregular tumor in the left hepatic lobe and swelling of lymph nodes. 18F-fluorodeoxy-glucose positron emission tomography (FDG-PET) showed high uptake by the tumor, with diffuse uptake in the spine. Based on the elevated leukocyte count and FDG-PET findings, the patient was diagnosed with a granulocyte colony-stimulating factor (G-CSF)-producing tumor (G-CSF, 213 pg/mL). We performed left trisegmentectomy of the liver, bile duct resection, and lymph node dissection. Histologically, the tumor was a poorly differentiated adenocarcinoma with some lymph nodes metastasis. Immunohistochemical staining of the tumor cells was positive for G-CSF. Therefore, the tumor was diagnosed as G-CSF–producing cholangiocellular carcinoma. The inflammatory reactions and serum G-CSF level transiently improved immediately after surgery. However, 1 month later, the leukocyte count and serum G-CSF level increased again, and recurrence was observed in the remnant liver. The patient died 3 months after the operation. G-CSF–producing cholangiocellular carcinoma is rare. This tumor progresses rapidly, and surgical treatment for advanced condition should be carefully selected.

Download Full-text

18F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors

Annals of Nuclear Medicine ◽

10.1007/s12149-008-0146-z ◽

2008 ◽

Vol 22 (7) ◽

pp. 635-639 ◽

Cited By ~ 25

Author(s):

Miyako Morooka ◽

Kazuo Kubota ◽

Yuji Murata ◽

Hitoshi Shibuya ◽

Kimiteru Ito ◽

...

Keyword(s):

Fdg Pet ◽

Lung Tumors ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Ct Findings ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Stimulating Factor ◽

Factor G

Download Full-text

Granulocyte-colony stimulating factor-producing gallbladder carcinoma-include analysis all case reports: A case report

International Journal of Surgery Case Reports ◽

10.1016/j.ijscr.2016.02.037 ◽

2016 ◽

Vol 21 ◽

pp. 87-90 ◽

Cited By ~ 2

Author(s):

Wataru Izumo ◽

Kenji Furukawa ◽

Hideo Katsuragawa ◽

Toru Tezuka ◽

Tatsuya Furukawa ◽

...

Keyword(s):

Case Report ◽

Gallbladder Carcinoma ◽

Case Reports ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Stimulating Factor

Download Full-text

Growth Factors and HIV-Infection in Children

Journal of International Medical Research ◽

10.1177/030006059302100605 ◽

1993 ◽

Vol 21 (6) ◽

pp. 342-345 ◽

Cited By ~ 5

Author(s):

G V Zuccotti ◽

P Flumine ◽

V Locatelli ◽

G Banderali ◽

E Riva

Keyword(s):

Growth Factors ◽

Leukocyte Count ◽

Combined Therapy ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Chronic Anaemia ◽

Acquired Immunodeficiency ◽

Immunodeficiency Syndrome ◽

Stimulating Factor

Three children with acquired immunodeficiency syndrome (AIDS) and chronic anaemia and leucopenia were treated with 5 μg/kg recombinant granulocyte colony-stimulating factor subcutaneously three times a week and 50 IU/kg erythropoietin subcutaneously twice a week. The therapy was not interrupted during the follow-up period. All children showed an increase of leukocyte count and haemoglobin levels. No transfusion was necessary and the number of admissions into hospital fell. These results suggest that combined therapy with granulocyte colony-stimulating factor and erythropoietin may improve leukopenia and anaemia, which is not zidovudine-related, in children who have AIDS.

Download Full-text

F-18 FDG PET Images of Uterine Cervical Cancer Producing Granulocyte Colony Stimulating Factor

Clinical Nuclear Medicine ◽

10.1097/rlu.0b013e3181f4a00c ◽

2010 ◽

Vol 35 (11) ◽

pp. 902-903 ◽

Cited By ~ 2

Author(s):

Masamichi Koyama ◽

Kazumasa Hayasaka ◽

Nobuhiro Takeshima ◽

Hiroko Machida ◽

Ken Takizawa

Keyword(s):

Cervical Cancer ◽

Fdg Pet ◽

Uterine Cervical Cancer ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Stimulating Factor

Download Full-text

Imaging findings of granulocyte colony-stimulating factor-producing tumors: a case series and review of the literature

Japanese Journal of Radiology ◽

10.1007/s11604-021-01130-8 ◽

2021 ◽

Author(s):

Shigeshi Kohno ◽

Akihiro Furuta ◽

Shigeki Arizono ◽

Koji Tokunaga ◽

Sei Nakao ◽

...

Keyword(s):

Bone Marrow ◽

Bone Scintigraphy ◽

Fdg Pet ◽

Imaging Findings ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Fdg Uptake ◽

Pet Ct ◽

Fdg Pet Ct ◽

Stimulating Factor

AbstractGranulocyte colony-stimulating factor (G-CSF)-producing tumors have an aggressive clinical course. Here, we report five cases of G-CSF-producing tumors and review the literature, focusing on imaging findings related to tumor-produced G-CSF. In addition to our cases, we identified 30 previous reports of G-CSF-producing tumors on which 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT, bone scintigraphy, or evaluation of bone marrow MR findings was performed. White blood cell count, serum C-reactive protein, and serum interleukin-6 were elevated in all cases for which these parameters were measured. G-CSF-producing tumors presented large necrotic masses (mean diameter 83.2 mm, range 17–195 mm) with marked FDG uptake (mean maximum standardized uptake value: 20.09). Diffuse FDG uptake into the bone marrow was shown in 28 of the 31 cases in which FDG-PET/CT was performed. The signal intensity of bone marrow suggested marrow reconversion in all seven MRI-assessable cases. Bone scintigraphy demonstrated no significant uptake, except in two cases with bone metastases. Splenic FDG uptake was increased in 8 of 10 cases in which it was evaluated. These imaging findings may reflect the effects of tumor-produced G-CSF. The presence of G-CSF-producing tumors should be considered in patients with cancer who show these imaging findings and marked inflammatory features of unknown origin.

Download Full-text