A Case of G-CSF–Producing Histiocytic Sarcoma of the Stomach

No reports have been published to date regarding primary gastric granulocyte colony–stimulating factor (G-CSF)–producing histiocytic sarcoma. We encountered a case of primary gastric histiocytic sarcoma that also fulfilled the criteria for a G-CSF–producing tumor. A 75-year-old man was diagnosed with gastric cancer with poorly differentiated adenocarcinoma. The patient's white blood cell count was elevated to 20,700/μL, and the G-CSF level was elevated to 380 pg/mL. A computed tomography scan showed hepatic infiltration; therefore, a preoperative diagnosis of T4 (liver) N2H0M0 cStage IV gastric cancer was made, and surgery was performed. No. 11d lymphatic metastasis was noted, resulting in invasion of the pancreatic tail, and combined resection of the liver, pancreas, and spleen was conducted with complete gastrectomy. The results of hematoxylin-eosin and immunohistochemical staining were subsequently assessed. On discharge, the G-CSF level had fallen to 22.7 pg/mL. Currently, the patient is still alive and has experienced no recurrence approximately 4 years after the operation.

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Preoperative multidetector-row computed tomography scan staging for lymphatic gastric cancer spread

World Journal of Surgical Oncology ◽

10.1186/1477-7819-10-197 ◽

2012 ◽

Vol 10 (1) ◽

Cited By ~ 10

Author(s):

Paolo Morgagni ◽

Enrico Petrella ◽

Barbara Basile ◽

Alberto Mami ◽

Augusto Soro ◽

...

Keyword(s):

Gastric Cancer ◽

Computed Tomography ◽

Multidetector Row Computed Tomography ◽

Computed Tomography Scan ◽

Multidetector Row ◽

Cancer Spread ◽

Tomography Scan

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Granulocyte Colony-Stimulating Factor-Producing Bladder Cancer

Case Reports in Oncology ◽

10.1159/000502174 ◽

2019 ◽

Vol 12 (2) ◽

pp. 603-607 ◽

Cited By ~ 2

Author(s):

Ryota Morinaga ◽

Takashi Kawahara ◽

Shinnosuke Kuroda ◽

Yoshiaki Inayama ◽

Hiroji Uemura

Keyword(s):

Bladder Cancer ◽

Blood Cell ◽

Cell Count ◽

Bladder Tumor ◽

Resected Specimen ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Blood Cell Count ◽

Gross Hematuria ◽

Stimulating Factor

Granulocyte colony-stimulating factor (G-CSF)-producing bladder cancer is rare, with only 75 cases reported in Japan. A 67-year-old woman was referred to our institution for the further examination of gross hematuria. Cystoscopy revealed a 7-cm bladder tumor. The initial white blood cell count was 17,100/μL, and a transurethral resected specimen showed G-CSF expression. CT revealed that the tumor had invaded the colon. As the patient had uncontrollable schizophrenia, radical cystectomy was abandoned. We herein report a case of G-CSF-producing bladder tumor.

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Spontaneous Regression of a Mandibular Plasmacytoma in a Juvenile Dog: A Case Report

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6932 ◽

2020 ◽

Vol 56 (3) ◽

Author(s):

Erika Villedieu ◽

Samuel Beck ◽

Laurent Findji

Keyword(s):

Computed Tomography ◽

Spontaneous Regression ◽

Round Cell ◽

Computed Tomography Scan ◽

Computed Tomography Scanning ◽

Cell Neoplasm ◽

Poorly Differentiated ◽

The Right ◽

Tomography Scan ◽

Tomography Scanning

ABSTRACT A 4 mo old female Finnish lapphund presented for further investigation of a swelling of the right rostral mandible. A computed tomography scan showed the swelling to be an expansile and osteolytic mandibular lesion. Histopathology revealed a poorly differentiated, moderately well-demarcated, unencapsulated, highly infiltrative round cell neoplasm, and immunohistochemistry was supportive of a plasmacytoma. Performance of a rostral partial mandibulectomy was initially discussed with the owners, but the lesion improved spontaneously both clinically and on repeated computed tomography scanning before surgery could be performed. It subsequently almost completely resolved 6 mo after diagnosis. Hypotheses for spontaneous regression of the lesion are discussed and the human literature is briefly reviewed.

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Stimulatory effects of granulocyte colony-stimulating factor on colony- forming units-spleen (CFU-S) differentiation and pre-CFU-S proliferation in mice

Blood ◽

10.1182/blood.v77.12.2597.2597 ◽

1991 ◽

Vol 77 (12) ◽

pp. 2597-2602 ◽

Cited By ~ 12

Author(s):

T Tanaka ◽

T Suda ◽

J Suda ◽

T Inoue ◽

Y Hirabayashi ◽

...

Keyword(s):

Mouse Bone Marrow ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Blood Cell Count ◽

Colony Forming Units ◽

Immature Myeloid Cells ◽

Polymerase Chain ◽

Buffer Control ◽

Macrophage Colony ◽

Stimulating Factor

Abstract Granulocyte colony-stimulating factor (G-CSF) was reported to increase the number of colony-forming units-spleen (CFU-S) and multilineage colonies as well as myeloid-committed cells. We investigated the effects of G-CSF on myeloid progenitors and primitive stem cells in a mouse bone marrow transplantation (BMT) system. Lethally irradiated mice received BM cells from untreated or 5-fluorouracil-treated mice, and then were administered G-CSF or carrier buffer (control) for 5 days from immediately after BMT. A pre-CFU-S assay was performed by the repeated transplantation of BM cells from the first BMT recipients to other mice. By the method of polymerase chain reaction, most of the spleen colonies in the secondary recipients were confirmed to be derived from the first donors. G-CSF did not increase the peripheral white blood cell count significantly, but did increase the number of immature myeloid cells and granulocyte-macrophage colony-forming cells in the BM. The number of erythroid cells in the BM was initially suppressed and then increased by G-CSF treatment. In addition, the pre- CFU-S assay showed an increase in pre-CFU-S cells due to G-CSF administration. The number of spleen colonies of first BMT recipients did not increase, but a higher percentage of them were committed to a certain lineage by G-CSF treatment. These findings suggest that G-CSF has important roles in the early stages of hematopoiesis.

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