Hormone replacement therapy in menopause as a risk factor for developing breast cancer

Objetivo: Analisar a produção científica envolvendo o uso da terapia de reposição hormonal no climatério como um fator de risco para desenvolvimento de câncer de mama. Método: Realizou-se uma revisão integrativa da literatura. Utilizamos as bases de dados BDENF, LILACS e SciELO. Identificamos 71 artigos, dos quais 24 compuseram nossa amostra. Resultados: Observamos que o Brasil foi o país com mais publicações e o idioma mais requisitado foi o português. Em relação à escolha do delineamento do estudo, 50% dos estudos possuíam abordagem metodológica do tipo qualitativa e o método de coleta de dados por meio de documentos foi o mais utilizado. Conclusão: A enfermagem como profissional da saúde deve orientar as mulheres em idade perimenopausa sobre os riscos e benefícios do uso da terapia de reposição hormonal a fim de auxiliá-las na adesão ou não a esse tratamento.

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Hormone replacement therapy in menopause as a risk factor for developing breast cancer

Revista de Pesquisa Cuidado é Fundamental Online ◽

10.9789/2175-5361.2014v6n3p1302 ◽

2014 ◽

Vol 6 (3) ◽

pp. 1302-1312

Author(s):

Natasha Souto ◽

Camila Moreira ◽

Paulo Augusto Barros ◽

Ana Fátima Fernandes ◽

Míria Santos

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Hormone Replacement Therapy ◽

Replacement Therapy ◽

Hormone Replacement

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Hormone replacement therapy and mortality in 52- to 70-year-old women: the Kuopio Osteoporosis Risk Factor and Prevention Study

Acta Endocrinologica ◽

10.1530/eje.1.02059 ◽

2006 ◽

Vol 154 (1) ◽

pp. 101-107 ◽

Cited By ~ 15

Author(s):

Kati Pentti ◽

Risto Honkanen ◽

Marjo T Tuppurainen ◽

Lorenzo Sandini ◽

Heikki Kröger ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factor ◽

Hormone Replacement Therapy ◽

Replacement Therapy ◽

Cancer Mortality ◽

Hormone Replacement ◽

Breast Cancer Mortality ◽

Prevention Study ◽

Osteoporosis Risk

Objectives: To analyze prospectively the association between hormone replacement therapy (HRT) and mortality in women before old age. Design and methods: A group of 11 667 women (91% of the age cohort of the area) aged 52–62 years from the population-based Kuopio Osteoporosis Risk Factor and Prevention Study were followed for 7 years in 1994–2001. Information about HRT use and health events was obtained from two repeated questionnaires in 1989 and 1994. Information about deaths and causes of death from the follow-up period was obtained from the Statistics Finland. Cox’s proportional-hazards models were used to calculate risk of death related to the use of HRT. Results: At the start of follow-up, 2203 women had used HRT >5 years, 3945 women ≤5 years and 5519 women had never used it. During the follow-up, 361 deaths occurred. Compared with non-users of HRT, the adjusted hazard ratio (HR) of death from any cause was 1.05 (95% confidence interval (CI) 0.80–1.36) in women who used HRT ≤5 years and 1.06 (95% CI 0.78–1.46) in women who used HRT >5 years. The adjusted HR for coronary heart disease (CHD) mortality in women who used HRT ≤5 years was 0.79 (95% CI 0.36–1.73), and in women who used HRT >5 years, 2.16 (95% CI 0.93–4.98). For breast cancer mortality the adjusted HR for ≤5 years of HRT use was 0.96 (95% CI 0.32–2.82) and 2.62 (95% CI 0.98–7.00) for >5 years of HRT use. Conclusions: History of HRT use does not affect overall or CHD mortality in women. More than 5 years of HRT use may increase the risk of breast cancer mortality.

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