familial correlation
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2019 ◽  
Vol 40 (6) ◽  
pp. 500-506
Author(s):  
Jason Charng ◽  
Paul G. Sanfilippo ◽  
Gareth Lingham ◽  
Louis J. Stevenson ◽  
David A. Mackey ◽  
...  




2015 ◽  
Vol 18 (6) ◽  
pp. 720-726 ◽  
Author(s):  
Shuai Li ◽  
Ee Ming Wong ◽  
JiHoon E. Joo ◽  
Chol-Hee Jung ◽  
Jessica Chung ◽  
...  

The disease- and mortality-related difference between biological age based on DNA methylation and chronological age (Δage) has been found to have approximately 40% heritability by assuming that the familial correlation is only explained by additive genetic factors. We calculated two different Δage measures for 132 middle-aged female twin pairs (66 monozygotic and 66 dizygotic twin pairs) and their 215 sisters using DNA methylation data measured by the Infinium HumanMethylation450 BeadChip arrays. For each Δage measure, and their combined measure, we estimated the familial correlation for MZ, DZ and sibling pairs using the multivariate normal model for pedigree analysis. We also pooled our estimates with those from a former study to estimate weighted average correlations. For both Δage measures, there was familial correlation that varied across different types of relatives. No evidence of a difference was found between the MZ and DZ pair correlations, or between the DZ and sibling pair correlations. The only difference was between the MZ and sibling pair correlations (p < .01), and there was marginal evidence that the MZ pair correlation was greater than twice the sibling pair correlation (p < .08). For weighted average correlation, there was evidence that the MZ pair correlation was greater than the DZ pair correlation (p < .03), and marginally greater than twice the sibling pair correlation (p < .08). The varied familial correlation of Δage is not explained by additive genetic factors alone, implying the existence of shared non-genetic factors explaining variation in Δage for middle-aged women.



PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137625 ◽  
Author(s):  
Ruud van Winkel ◽  
Keyword(s):  


2015 ◽  
Vol 23 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Michal Gazer-Snitovsky ◽  
Ayelet Brand-Gothelf ◽  
Gal Dubnov-Raz ◽  
Abraham Weizman ◽  
Doron Gothelf

Objective: To examine whether a familial tendency exists in clinical response to methylphenidate. Method: Nineteen pairs of siblings or parent–child stimulant-naive individuals with ADHD were prescribed methylphenidate–immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale. Results: We found significant intraclass correlations in family member response to methylphenidate–immediate release and side effect profile, including emotional symptoms and loss of appetite and weight. Conclusion: Family history of response to methylphenidate should be taken into account when treating ADHD.



PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87100 ◽  
Author(s):  
Yung-Kai Huang ◽  
Wei-Fang Lee ◽  
Meng-Jiy Wang ◽  
Yus-Han Sophie Chang ◽  
Wen-Shiun Tchaou ◽  
...  


2013 ◽  
Vol 54 (8) ◽  
pp. 5638 ◽  
Author(s):  
Ling-Jun Li ◽  
Jiemin Liao ◽  
Qiao Fan ◽  
Carol Yim-lui Cheung ◽  
M. Kamran Ikram ◽  
...  


2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Yang Hu ◽  
Liu He ◽  
Yangfeng Wu ◽  
Guansheng Ma ◽  
Liming Li ◽  
...  


2010 ◽  
Vol 122 (5) ◽  
pp. 395-404 ◽  
Author(s):  
T. Lataster ◽  
D. Collip ◽  
M. Lardinois ◽  
J. Van Os ◽  
I. Myin-Germeys


2010 ◽  
Vol 28 (6) ◽  
pp. 690-695 ◽  
Author(s):  
Hiroaki Ohta ◽  
Tatsuhiko Kuroda ◽  
Yoshiko Onoe ◽  
Chie Nakano ◽  
Remi Yoshikata ◽  
...  


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