RhodiumIII-Catalyzed Successive Csp2‒H and Csp2‒Csp2 Bond Activation of Aryl Oximes: Synthetic and Mechanistic Studies

Author(s):  
Guo-Jun Deng ◽  
Cheng Li ◽  
Fuhong Xiao ◽  
Huawen Huang ◽  
Bin Zhao

Merging selective C–H cleavage with C–C cleavage in a tandem reaction has been a practical strategy that permits skeletal diversification from simple raw materials. Herein, we describe a rhodiumIII-catalyzed redox-neutral...

Synthesis ◽  
2017 ◽  
Vol 49 (16) ◽  
pp. 3569-3575 ◽  
Author(s):  
Junji Ichikawa ◽  
Yota Watabe ◽  
Kohei Kanazawa ◽  
Takeshi Fujita

2-Fluoro-1,3-dienes were synthesized through nickel-catalyzed coupling reactions between β,β-difluorostyrenes and alkynes in the presence of ZrF4 as co-catalyst and a hydride source derived from triethylborane and lithium isopropoxide. Mechanistic studies revealed that the carbon–fluorine bond was cleaved by β-fluorine elimination from intermediary nickelacyclopentenes generated through oxidative cyclization of the two substrates.


ChemInform ◽  
2015 ◽  
Vol 46 (39) ◽  
pp. no-no
Author(s):  
Sara Ruiz ◽  
Pedro Villuendas ◽  
Manuel A. Ortuno ◽  
Agusti Lledos ◽  
Esteban P. Urriolabeitia

2021 ◽  
Author(s):  
Fulin Zhang ◽  
Ruihua Zhao ◽  
Lei Zhu ◽  
Yinghua Yu ◽  
Saihu Liao ◽  
...  

<b>Isoindolinone is a class of versatile <i>N</i>-heterocycles embedded in many bioactive molecules and natural products. The invention of new methods to synthesize these heterocyclic compounds with easily accessible chemicals is always attractive. Herein, a conceptually novel approach to access this bicyclic system via isonitrile insertion enabled 1,4-pallaidum shift is described. Compared with conventional isonitrile participated C-H bond activation, both carbon and nitrogen atoms in isonitrile moiety are engaged in new bond formation. Notably, two different isoindolinones can be obtained selectively by switching the bases employed. Mechanistic studies including DFT calculations have shed lights on the reaction mechanism and explained the selectivity led to different products. Moreover, the power of current benzolactamization is further demonstrated by providing concise routes to key intermediates of indoprofen, indobufen, aristolactams, lennoxamine and falipamil.</b>


2021 ◽  
Author(s):  
Jee Khan Lim ◽  
Julian Müller ◽  
Fatin Norsuaidah Mahdi ◽  
Soo Kien Chen ◽  
Kar Ban Tan ◽  
...  

Today's disposable diapers have become an indispensable choice among hygiene products, reflected in their massive global consumption and waste generation. Most of the diaper waste is neither segregated nor treated and ends up in landfills or incinerators. The reported life cycle assessment highlights that the diaper waste is not solely generated after single-use but begins as early as the raw materials acquisition stage. Although what is done cannot be undone, diaper waste can be recycled. Diaper waste valorization has been explored on laboratory- and commercial-scales for years, with varying degrees of success. Leading diaper manufacturers such as Procter & Gamble, Kimberley-Clark and Unicharm are making progress in establishing closed-loop recycling of used diapers and converting diaper waste into new diapers. However, the wide window of possible new products made from diaper waste has yet to be fully exploited. This review focuses on the enormous promise of diaper waste from the perspective of emerging open-loop recycling pathways. We demonstrate that diaper waste was harnessed and converted into non-diaper products, including energy pellets, anode material for lithium-ion batteries, concrete admixture, catalysts, soil amendment, and mushroom cultivation substrates. We also explore several active, commercial-scale diaper recycling approaches and provide a comprehensive blueprint to encourage open-loop recycling. Open-loop recycling is a practical strategy for managing diaper waste, rectifying environmental damage, and contributing to circular supply chains.


2014 ◽  
Vol 279 ◽  
pp. 115-140 ◽  
Author(s):  
Margarita Crespo ◽  
Manuel Martínez ◽  
S. Masoud Nabavizadeh ◽  
Mehdi Rashidi

2006 ◽  
Vol 12 (12) ◽  
pp. 3261-3274 ◽  
Author(s):  
David Cuperly ◽  
Julien Petrignet ◽  
Christophe Crévisy ◽  
René Grée

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