triplet repeat sequences
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2015 ◽  
Vol 71 (10) ◽  
pp. 2119-2126 ◽  
Author(s):  
Arunachalam Thirugnanasambandam ◽  
Selvam Karthik ◽  
Pradeep Kumar Mandal ◽  
Namasivayam Gautham

The structure of the decadeoxyribonucleotide d(GCATGCATGC) is presented at a resolution of 1.8 Å. The decamer adopts a novel double-folded structure in which the direction of progression of the backbone changes at the two thymine residues. Intra-strand stacking interactions (including an interaction between the endocylic O atom of a ribose moiety and the adjacent purine base), hydrogen bonds and cobalt-ion interactions stabilize the double-folded structure of the single strand. Two such double-folded strands come together in the crystal to form a dimer. Inter-strand Watson–Crick hydrogen bonds form four base pairs. This portion of the decamer structure is similar to that observed in other previously reported oligonucleotide structures and has been dubbed a `bi-loop'. Both the double-folded single-strand structure, as well as the dimeric bi-loop structure, serve as starting points to construct models for triplet-repeat DNA sequences, which have been implicated in many human diseases.


2008 ◽  
Vol 16 (11) ◽  
pp. 5899-5907 ◽  
Author(s):  
Jun Fujimoto ◽  
Toshikazu Bando ◽  
Masafumi Minoshima ◽  
Shinsuke Uchida ◽  
Makoto Iwasaki ◽  
...  

2002 ◽  
Vol 2 (1) ◽  
pp. 231-232 ◽  
Author(s):  
N. Tomita ◽  
R. Fujita ◽  
D. Kurihara ◽  
H. Shindo ◽  
R. D. Wells ◽  
...  

IUBMB Life ◽  
2000 ◽  
Vol 50 (6) ◽  
pp. 355-359 ◽  
Author(s):  
John Jakupciak ◽  
Robert Wells

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