Profiles of patients with psoriasis for appointment gene-engineering biological therapy — clinical justification

Psoriasis is a chronic immune-mediated disease with predominant damage to the skin and musculoskeletal system. This paper describes the clinical manifestations of psoriasis requiring a special therapeutic approach. The profiles of patients who showed the early assignment of genetic engineering biological therapy: patients with moderate and severe psoriasis, with rashes of problem localization (skin of the face, scalp, genital area and palmar-plantar region), with severe psoriatic lesion of the nail plates, as well as psoriatic arthritis. Clinical cases of rapid and pronounced resolution of rashes with the use of the new drug netakimab (Efleira) in a dosage of 120 mg according to the standard regimen psoriasis patients with indications for systemic or phototherapy.

SLA-driven adaptive monitoring of distributed applications for performance problem localization

Continuous monitoring of software systems under production workload provides valuable data about application runtime behavior and usage. An adaptive monitoring infrastructure allows controlling, for instance, the overhead as well as the granularity and quality of collected data at runtime. Focusing on application-level monitoring, this paper presents the DProf approach which allows changing the instrumentation of software operations in monitored distributed applications at runtime. It simulates the process human testers employ-monitoring only such parts of an application that cause problems. DProf uses performance objectives specified in service level agreements (SLAs), along with call tree information, to detect and localize problems in application performance. As a proof-of-concept, DProf was used for adaptive monitoring of a sample distributed application.