In this paper, we investigate the relativistic dynamics of a fermion–antifermion pair holding through Dirac oscillator interaction in the rotating frame of [Formula: see text]-dimensional topological defect-generated geometric background. We obtain an exact energy spectrum for the system in question by solving the corresponding form of a fully covariant two-body Dirac equation. This energy spectrum depends on the angular velocity [Formula: see text] of uniformly rotating frame and angular deficit [Formula: see text] in the geometric background. Our results show that the effects of [Formula: see text] on each energy level of the system are not same and the [Formula: see text] impacts on the strength of interaction between the particles. Furthermore, we observe that it seems to be possible to actively tune the dynamics of such a fermion–antifermion system, in principle.