This paper is concerned with compactifications of high-dimensional manifolds. Siebenmann’s iconic 1965 dissertation [L. C. Siebenmann, The obstruction to finding a boundary for an open manifold of dimension greater than five, Ph.D. thesis, Princeton Univ. (1965), MR 2615648] provided necessary and sufficient conditions for an open manifold [Formula: see text] ([Formula: see text]) to be compactifiable by addition of a manifold boundary. His theorem extends easily to cases where [Formula: see text] is noncompact with compact boundary; however, when [Formula: see text] is noncompact, the situation is more complicated. The goal becomes a “completion” of [Formula: see text], i.e. a compact manifold [Formula: see text] containing a compactum [Formula: see text] such that [Formula: see text]. Siebenmann did some initial work on this topic, and O’Brien [G. O’Brien, The missing boundary problem for smooth manifolds of dimension greater than or equal to six, Topology Appl. 16 (1983) 303–324, MR 722123] extended that work to an important special case. But, until now, a complete characterization had yet to emerge. Here, we provide such a characterization. Our second main theorem involves [Formula: see text]-compactifications. An important open question asks whether a well-known set of conditions laid out by Chapman and Siebenmann [T. A. Chapman and L. C. Siebenmann, Finding a boundary for a Hilbert cube manifold, Acta Math. 137 (1976) 171–208, MR 0425973] guarantee [Formula: see text]-compactifiability for a manifold [Formula: see text]. We cannot answer that question, but we do show that those conditions are satisfied if and only if [Formula: see text] is [Formula: see text]-compactifiable. A key ingredient in our proof is the above Manifold Completion Theorem — an application that partly explains our current interest in that topic, and also illustrates the utility of the [Formula: see text]-condition found in that theorem.