heart innervation
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2019 ◽  
Vol 39 (5) ◽  
pp. 364-370
Author(s):  
Tais H.C. Sasahara ◽  
Marcia R.F. Machado

ABSTRACT: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.



2017 ◽  
Vol 95 (11) ◽  
pp. 1351-1359 ◽  
Author(s):  
Dagmar Jarkovska ◽  
Monika Bludovska ◽  
Eliska Mistrova ◽  
Vera Krizkova ◽  
Dana Kotyzova ◽  
...  

Liver cirrhosis is associated with impairment of cardiovascular function including alterations of the heart innervation, humoral and nervous dysregulation, changes in systemic circulation and electrophysiological abnormalities. Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH), and dopamine-β-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters, and atrial natriuretic peptide (ANP) is produced by cardiomyocytes. The aim of this study was to evaluate the influence of experimentally induced hepatic dysfunction on the expression of proANP, ChAT, TH, and DBH in the heart. Hepatic dysfunction was induced by application of thioacetamide (TAA) or by ligation of bile duct. Biochemical parameters of hepatic injury and levels of peroxidation in the liver and heart were measured. Liver enzymes measured in the plasma were significantly elevated. Cardiac level of peroxidation was increased in operated but not TAA group animals. In the left atrium of operated rats, the expression of TH and DBH was lower, while expression of ChAT remained unchanged. In TAA group, no significant differences in the expression of the genes compared to controls were observed. Liver injury induced by ligation leads to an imbalance in the intracardiac innervation, which might impair nervous control of the heart.



Neuropeptides ◽  
2016 ◽  
Vol 55 ◽  
pp. 47-54 ◽  
Author(s):  
Petr M. Masliukov ◽  
Konstantin Moiseev ◽  
Andrey I. Emanuilov ◽  
Tatyana A. Anikina ◽  
Alexey A. Zverev ◽  
...  


2016 ◽  
Vol 67 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Raffaele Marfella ◽  
Michelangela Barbieri ◽  
Celestino Sardu ◽  
Maria Rosaria Rizzo ◽  
Mario Siniscalchi ◽  
...  


Neuropeptides ◽  
2016 ◽  
Vol 55 ◽  
pp. 24-25
Author(s):  
Petr M. Masliukov ◽  
Konstantin Moiseev ◽  
Alexey A. Zverev ◽  
Tatyana A. Anikina


2013 ◽  
Vol 177 (1) ◽  
pp. 53
Author(s):  
P.M. Masliukov ◽  
A.I. Emanuilov ◽  
V.V. Konovalov ◽  
T.A. Anikina ◽  
A.A. Zverev ◽  
...  


2008 ◽  
Vol 40 (9) ◽  
pp. 3020-3022
Author(s):  
C. Ruiz Llorca ◽  
L. Almenar Bonet ◽  
J.L. Vercher Conejero ◽  
T. Mut Dólera ◽  
C. Olivas Arroyo ◽  
...  




2000 ◽  
Vol 27 (3) ◽  
pp. 333-339 ◽  
Author(s):  
Montserrat Estorch ◽  
Albert Flotats ◽  
Ricard Serra-Grima ◽  
Carina Marí ◽  
Teresa Prat ◽  
...  


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