scholarly journals Expression of classical mediators in hearts of rats with hepatic dysfunction

2017 ◽  
Vol 95 (11) ◽  
pp. 1351-1359 ◽  
Author(s):  
Dagmar Jarkovska ◽  
Monika Bludovska ◽  
Eliska Mistrova ◽  
Vera Krizkova ◽  
Dana Kotyzova ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Bile Duct ◽  
Biochemical Parameters ◽  
Hepatic Injury ◽  
Hepatic Dysfunction ◽  
Liver Enzymes ◽  
Systemic Circulation ◽  
Nervous Control ◽  
Heart Innervation ◽  
Noradrenaline Synthesis

Liver cirrhosis is associated with impairment of cardiovascular function including alterations of the heart innervation, humoral and nervous dysregulation, changes in systemic circulation and electrophysiological abnormalities. Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH), and dopamine-β-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters, and atrial natriuretic peptide (ANP) is produced by cardiomyocytes. The aim of this study was to evaluate the influence of experimentally induced hepatic dysfunction on the expression of proANP, ChAT, TH, and DBH in the heart. Hepatic dysfunction was induced by application of thioacetamide (TAA) or by ligation of bile duct. Biochemical parameters of hepatic injury and levels of peroxidation in the liver and heart were measured. Liver enzymes measured in the plasma were significantly elevated. Cardiac level of peroxidation was increased in operated but not TAA group animals. In the left atrium of operated rats, the expression of TH and DBH was lower, while expression of ChAT remained unchanged. In TAA group, no significant differences in the expression of the genes compared to controls were observed. Liver injury induced by ligation leads to an imbalance in the intracardiac innervation, which might impair nervous control of the heart.

Increased serum levels of quinolinic acid indicate enhanced severity of hepatic dysfunction in patients with liver cirrhosis

2013 ◽  
Vol 74 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Imad Lahdou ◽  
Mahmoud Sadeghi ◽  
Hani Oweira ◽  
Gerhard Fusch ◽  
Volker Daniel ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Quinolinic Acid ◽  
Hepatic Dysfunction ◽  
Serum Levels

Liver cirrhosis developed after ketoconazole-induced acute hepatic injury

2003 ◽  
Vol 18 (12) ◽  
pp. 1426-1429 ◽  
Author(s):  
TAE-HYUNG KIM ◽  
BYUNG-HO KIM ◽  
YOUN-WHA KIM ◽  
DAL MO YANG ◽  
YO-SEB HAN ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Injury ◽  
Acute Hepatic Injury

Study of brainstem auditory evoked response and biochemical markers in patients of alcohol use disorder

2021 ◽  
Vol 65 ◽  
pp. 193-200
Author(s):  
Mudassir Anis Siddiqui ◽  
Divya Srivastava ◽  
Sandeep Choudhary
Keyword(s):  
Alcohol Use ◽  
Biochemical Parameters ◽  
Alcoholic Hepatitis ◽  
Alcohol Use Disorder ◽  
Liver Enzymes ◽  
Evoked Response ◽  
Transmission Time ◽  
Control Group ◽  
Auditory Evoked Response ◽  
Brainstem Auditory Evoked Response

Objectives: Data available on brainstem auditory evoked response (BAER) and its correlation with biochemical parameters in patients of alcohol use disorder (AUD) in Indian population is scanty. Therefore, this study was undertaken to focus on the effects of AUD on BAER and liver enzymes. Materials and Methods: This case-control study included 40 males in the study group who had AUD and 40 healthy males in the control group in the age group of 20–60 years. The BAER was performed using octopus NCS/ EMG/EP (Clarity) machine. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase and serum bilirubin were estimated in all the subjects. Results: We observed a highly significant increase in the absolute latencies of waves III and V and interpeak latencies (IPL) I-III and I-V of BAER in the patients of AUD in this study. Significant increase in the liver enzymes and especially AST/ALT ratio of patients of AUD was seen which indicated towards subclinical alcoholic hepatitis. The latencies of waves of EPs (waves III, V, IPL I-III and IPL I-V) were positively correlated with the biochemical parameters and duration of AUD. Conclusion: Our findings indicated that AUD lead to the increase in brainstem transmission time and also lead to subclinical alcoholic hepatitis which is reflected by the increase in the liver enzymes. We concluded that chronic alcohol consumption affected the auditory pathways and delayed the auditory transmission time which was suggestive of possible demyelination of auditory tracts.

scholarly journals Single-operator cholangioscopy for diagnosis of cholangioadenoma (bile duct adenoma) and its potential impact on surgical management

2018 ◽  
Vol 06 (11) ◽  
pp. E1312-E1316 ◽  
Author(s):  
John Eccles ◽  
Aducio Thiesen ◽  
Gurpal Sandha
Keyword(s):  
Bile Duct ◽  
Surgical Management ◽  
Liver Enzymes ◽  
Clinical Indication ◽  
Targeted Biopsy ◽  
Patient Demographics ◽  
Single Operator ◽  
Potential Impact ◽  
Per Oral

Abstract Background and study aims Cholangioadenoma is not recognized commonly and is often only diagnosed on surgical specimens. Direct per oral single-operator cholangioscopy (SOC) allows characterization of common bile duct (CBD) lesions through direct visualization and directed forceps biopsies with potential for impacting surgical management decisions. This is a retrospective review of all SOC cases diagnosed with cholangioadenoma. Patient demographics and outcomes were recorded. Three patients (all male), average age 68 years (range 62 – 76 years), were identified to have a cholangioadenoma. The clinical indication for SOC was deranged liver enzymes with a dilated CBD and a CBD abnormality identified on biliary imaging. The site of cholangioadenoma was proximal, mid and distal CBD, respectively. All patients had a successful SOC with targeted biopsy-proven diagnosis. One patient had a synchronous cholangiocarcinoma and underwent palliative stenting whereas the other two patients underwent appropriate curative resection based on cholangioadenoma location. We conclude that SOC is safe and effective for diagnosis of cholangioadenoma and has potential impact on decisions for surgical management.

scholarly journals Splenomegaly and thrombocytopenia in patients with liver cirrhosis

2010 ◽  
Vol 67 (2) ◽  
pp. 166-169 ◽  
Author(s):  
Jelena Djordjevic ◽  
Petar Svorcan ◽  
Dusica Vrinic ◽  
Branka Dapcevic
Keyword(s):  
Risk Factors ◽  
Liver Cirrhosis ◽  
Platelet Count ◽  
Portal Hypertension ◽  
Hepatic Dysfunction ◽  
Spleen Size ◽  
Hepatitis Viruses ◽  
Decompensated Liver Cirrhosis ◽  
Splenic Sequestration ◽  
Frequent Finding

Backgroud/Aim. Splenomegaly is a frequent finding in patients with liver cirrhosis and portal hypertension and may cause hypersplenism. The occurrence of thrombocytopenia in those patients can be considered as an event with multiple etiologies. Two mechanisms may act alone or synergistically with splenic sequestration. One is central which involves either myelosuppression because of hepatitis viruses or the toxic effects of alcohol abuse on the bone marrow. The second one involves the presence of antibodies against platelets. It also depends upon the stage and etiology of liver disease. The aim of the study was to investigate a correlation between the platelet count and spleen size and the risk factors for thrombocytopenia in patients with liver cirrhosis. Methods. We studied 40 patients with decompensated liver cirrhosis who were hospitalized in the Department of Gastroenterohepatology. The liver function was graded according to Child Pugh score. Spleen size was defined ultrasonografically on the basis of craniocaudal length. Suspicion of portal hypertension was present when longitudinal spleen length was more than 11 cm. Thrombocytopenia was determined by platelet count under 150 000/mL. Results. We did not find any significant correlation between hepatic dysfunction and spleen size (p = 0.9), and between hepatic dysfunction and thrombocytopenia (p = 0.17). Our study did not find any significant correlation between spleen size and peripheral platelet count (p = 0.5), but we found a significant correlation between thrombocytopenia and etiology of cirrhosis - decreased platelet count was more common among patients with cirrhosis of alcoholic etiology than in other etiologies of cirrhosis (p = 0.001). Conclusion. According to our study, liver cirrhosis, portal hypertension and thrombocytopenia could be present even in the absence of enlarged spleen suggesting the involvement of other mechanisms of decreasing platelet account.

scholarly journals COMPARISON OF BIOCHEMICAL PARAMETERS OF PATIENTS WITH LIVER CIRRHOSIS WITH AND WITHOUT COVID-19

InterConf ◽  
2021 ◽  
pp. 288-294
Author(s):  
Nurgul Toktogulova ◽  
Elvira Zhakisheva ◽  
Turarbek Kaliev ◽  
Umid Satarov ◽  
Alena Smirnova
Keyword(s):  
Liver Cirrhosis ◽  
Liver Damage ◽  
Biochemical Parameters ◽  
Clinical Course ◽  
Age Groups ◽  
Coronavirus Infection ◽  
Liver Tests

There have been many published studies on how COVID-19 can affect the liver and how the severity of liver damage can influence the clinical course of COVID-19. The article describes the features of the biochemical parameters of the liver in different age groups developing with a new coronavirus infection using the example of observations in the department of gastroenterology. In patients under 60 years of age with liver cirrhosis in combination with Covid-19, along with deeper changes in liver tests, a decrease in hemoglobin, leukopenia and thrombocytopenia was observed.

scholarly journals Intraductal papillary neoplasm of the bile duct in liver cirrhosis with hepatocellular carcinoma

2011 ◽  
Vol 17 (14) ◽  
pp. 1923 ◽  
Author(s):  
Jing Xu ◽  
Yasunori Sato ◽  
Kenichi Harada ◽  
Norihide Yoneda ◽  
Teruyuki Ueda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Bile Duct ◽  
Intraductal Papillary Neoplasm ◽  
Papillary Neoplasm

scholarly journals Effect of Introducing the Jordanian Common Rue (Ruta chalepensis L.) on Liver Enzymes and Lipid Peroxidation in Adult Male Sprague Dawley Rats Toxified With Paracetamol

2020 ◽  
Vol 12 (4) ◽  
pp. 298
Author(s):  
Dana N. Abdelrahim ◽  
Hamed R. Takruri ◽  
Khalid M. Al-Ismail
Keyword(s):  
Lipid Peroxidation ◽  
Hepatic Injury ◽  
Liver Enzymes ◽  
Liver Weight ◽  
Normal Diet ◽  
High Cholesterol Diet ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
Ruta Chalepensis ◽  
Sprague Dawley Rats

This study aimed to determine the effect of Ruta chalepensis L. plant on liver enzymes, liver weight and lipid peroxidation using rats toxified with paracetamol. An animal experiment was conducted using five groups of Sprague Dawley rats, 9 rats each. The groups were fed: Normal diet, high cholesterol diet, with or without the plant or the liver toxicant paracetamol (PCM). The experiment lasted six weeks; at the end of the sixth week; a single dose of 3 g paracetamol/kg body weight was given for rats of two groups, then blood and liver samples were collected. The hepatoprotective effect of the plant was evaluated using aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin (TBL) levels as indicators. This study finds that the groups to which plant and PCM were given had significantly lower MDA levels in comparison with other groups that didn’t receive plant before PCM toxification. Tested liver enzymes levels were significantly (P < 0.05) lowered by the introduction of plant to the diet. Introducing PCM without ingestion of plant in the diet significantly (P < 0.05) increased the rats absolute liver weight. It is concluded that the use of Ruta chalepensis L. plant significantly lowered hepatic toxicity as indicated by the liver enzymes levels. Also, the plant lowered the MDA level and liver weight. The ingestion of the plant can be significantly protective against hepatic injury.

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