Design and In Vivo Evaluation of a Novel Transdermal Hydrogen/Oxygen-Generating Patch

Hydrogen/oxygen-generating biomaterials, a new trend in regenerative medicine, generate and supply hydrogen/oxygen to increase the local levels of hydrogen/oxygen to support tissue healing and regeneration. In this study, we carefully defined a strategic plan to develop a gas-permeable layer suitable for use in sanitary products that is capable of supplying hydrogen or oxygen in situ using calcium hydroxides as chemical oxygen sources. In vitro physicochemical evaluations of hydrogen- and oxygen-generation efficiency were performed to determine the amount of hydrogen and oxygen produced. An in vivo permeation study was conducted to assess biological parameters, including blood oxygen (O2) and hydrogen (H+) levels. The stress hormone corticosterone and inflammation marker interleukin 6 (IL-6) were also quantified. The hydrogen/oxygen-generating patch (HOGP) continuously generated H+ or O2 for up to 12 h after activation by water. An in vivo evaluation showed blood H+ peaked at 2 h after application of the HOGP and then progressively decreased until the end of study (24 h), whereas oxygen content (O2(ct)) and oxygen saturation (SO2(SAT)) continuously increased up to 6 h. Hematological and electrolyte parameters did not significantly change compared to baseline. Wearing the stretch fabric used to secure the patch did not significantly increase serum corticosterone or interleukin 6 (IL-6) in the animals. This novel design of a hydrogen/oxygen-generating biomaterial for supplying topical H+/O2 may hold potential for increasing in situ or circulating H+/O2 levels to improve healthcare outcomes.

THE TECHNOLOGY OF “STRETCH” FABRIC PRODUCTION IN A SMALL FACTORY

The article presents an improved technology for joining yarn from natural fibres with elastic filament of yarn using compressed air. The technological scheme of the process is presented. The main working parts of the thread connecting machine are shown – the tangential winding unit of the elastane thread, the additional tension zone, the pneumatic processing zone, the winding zone. The resulting thread is used as a weft in the production of light “stretch” fabrics. The necessity of performing the operation of relaxation and heat fixation of the fabrics is substantiated. The prospects of applying the new technology at small enterprises in the textile industry are shown. Information about the features of the production technology is presented. References are given to works previously published by the authors, as well as by the experience of leading European specialists. The large volume of research performed allows considering this development ready for implementation.

The Idea of Designing an Amphitheater in the Besh Qardash of Bojnord (Tourist Destination and Recreational Region) with Stretch Fabric Structures

One of the criteria for sustainable design is "the principle of adaptation to local regions". In this case, the native, historical, cultural and specific characteristics of the region are considered. This study tried to use an idea of designing an amphitheater in the Besh Qardash of Bojnourd (tourist destination and recreational region) with stretch fabric structures as the contemporary structural systems that have a certain similarity to nomadic tents which along with being in line with the historical and cultural elements of the region, including the historical tomb next to the spring, present a combination of modern and local architecture. This can be a great help to hold ceremonies and cultural events in this location, such as holding traditional wrestling competitions (Ba Chukhe) and horse racing (Turkman horse) in special time of the year. In the following parts, along with introducing the geographical and climatic conditions of the region by examining the technical and executive characteristics of stretch fabric structures, the results will be presented.