Construction, Molecular Docking, Antimicrobial and Antioxidant Activity of Some Novel 3-Substitued Indole Derivatives Using 3-Acetyl Indole

This dissertation presents a method for the synthesis of substituted indoles bearing heterocyclic substituents onto the 3- position. The route for the synthesis of the heterocyclic substituents indoles starts from 3-acetyl indole nucleus depend on two parts. One part: Reaction of 3-acetylindole 1 with hydrazide compounds such as phenyl hydrazine, hydrazine hydrate, and thio-semicarbazide, to yield 3-(1-(2-phenylhydrazono) ethyl)-1H-indole 2, 3-(1-hydrazonoethyl)-1H-indole 6, and thiosemicarbazone 10 respectively. 3-(1-Hydrazonoethyl)-1H-indole 6 reacted with thiophene-2-carboxaldeyde, isatin and 3-acetyl indole. In the same way, 3-(1-(2-phenylhydrazono) ethyl)-1H-indole 2 reacted with thioglycollic acid, glycine and benzaldehyde. 3-Acetylindole 1 thiosemicarbazone reacted with acetic anhydride, piperidine, concentration of hydrochloric acid and thiophene-2-carboxaldeyde. Second part. Reaction of 3-acetyl indole 1 with amines compounds such as p-nitroaniline to formed Schiff base 15 which it reacted with thioglycollic acid to give compound 16. 3-Acetyl indole 1 reacted with ethylene diamine to afford bis imine indole to afford compound 17. The reports of this docking study revealed that the new compounds exhibit good antibacterial activity. The synthesized compounds screened in vitro for their antibacterial activity revealed remarkable inhibitory effects against the selected microorganisms. And also an anti-oxidant activity studying for some synthesized compounds. Structures of the newly synthesized compounds examination by spectral data (IR, 1H- NMR and 13C -NMR).

Synthesis of 4,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(6H)-one derivatives by solid acid-catalyzed multi-component reaction in water

A solid acid is found to efficiently catalyze the condensation of substituent-pyrazoles, aldehydes, and thioglycollic acid to afford a wide range of pyrazolo[3,4-e][1,4]thiazepine derivatives with good to excellent yields.

Response of bio-regulators to yield and quality of Indian mustard (Brassica juncea L. Czernj. and Cosson) under different irrigation environments

A field study was conducted during rabi seasons of 2008 and 2009 to evaluated of productivity of Indian mustard (Brassica juncea L.) by foliar spray of bio-regulators under different irrigation environments. Amongst treatments, the application of sufficient irrigation water (four irrigations) recorded the highest number siliqua per plant, higher number of seeds per siliqua, 1000 seed weight and yields as compared to all other irrigation treatments. Results show that an increased in seed yield of 92.40 and 39.37 % under sufficient irrigation and limitedwater condition in 2008 and 93.34% and 40.31% in 2009, respectively over deficient irrigation conditions, foliar sprays of 100 ppm thioglycollic acid at initiation of branching were recorded highest yield attributes and yields. Similarly, 500 ppm of thiourea at initiation of branching and flowering stages also gave second best highest yield attributes and yields as compared to all other bio-regulators spray stages. However, bio-regulators sprays were not recorded any significant effect on oil and protein content. The results were concluded that economic feasibility to improve productivity of Indian mustard with four irrigations levels and sprays of 100 ppm thioglycollic acid and 500 ppm of thiourea at initiation of branching and flowering stages under hyper arid environment.