Sierpinski graphs are a widely observed family of fractal-type graphs relevant to topology, Hanoi Tower mathematics, computer engineering, and around. Chemical implementations of graph theory establish significant properties, such as chemical activity, physicochemical properties, thermodynamic properties, and pharmacological activities of a molecular graph. Specific graph descriptors alluded to as topological indices are helpful to predict these properties. These graph descriptors have played a key role in quantitative structure-property/structure-activity relationships (QSPR/QSAR) research. The objective of this article is to compute Randic index (
R
−
1
/
2
), Zagreb index
M
1
, sum-connectivity index
SCI
, geometric-arithmetic index
GA
, and atom-bond connectivity
ABC
index based on ev-degree and ve-degree for the Sierpinski networks
S
n
,
m
.