cisplatin analogues
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scholarly journals Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2739 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chun Wu ◽  
Ke-Jia Wu ◽  
Chung-Hang Leung
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Anticancer Agents ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Lower Toxicity ◽  
Cisplatin Analogues

Targeting apoptosis is a principal strategy in the design of anticancer drugs. In recent years, non-platinum-based scaffolds have been exploited as viable candidates for the exploitation of anticancer agents with potentially lower toxicity than the widely used cisplatin analogues. This review highlights the latest advances in developing iridium(III) complexes as anticancer agents that act particularly via targeting apoptotic cell death in cancer cells.

Interactions of cisplatin analogues with lysozyme: a comparative analysis

BioMetals ◽  
2017 ◽  
Vol 30 (5) ◽  
pp. 733-746 ◽  
Author(s):  
Giarita Ferraro ◽  
Ilaria De Benedictis ◽  
Annamaria Malfitano ◽  
Giancarlo Morelli ◽  
Ettore Novellino ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Cisplatin Analogues

Cisplatin and cisplatin analogues perfusion through isolated rat heart: the effects of acute application on oxidative stress biomarkers

2017 ◽  
Vol 439 (1-2) ◽  
pp. 19-33 ◽  
Author(s):  
Isidora M. Stojic ◽  
Vladimir I. Zivkovic ◽  
Ivan M. Srejovic ◽  
Tamara R. Nikolic ◽  
Nevena S. Jeremic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Oxidative Stress Biomarkers ◽  
Cisplatin Analogues ◽  
Stress Biomarkers ◽  
Isolated Rat

Cisplatin Analogues with an Increased Interaction with DNA: Prospects for Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6645-6664 ◽  
Author(s):  
Megan Hardie ◽  
Hieronimus Kava ◽  
Vincent Murray
Keyword(s):  
Cisplatin Analogues

scholarly journals Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

ChemMedChem ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. 183-192 ◽  
Author(s):  
Wilma Neumann ◽  
Brenda C. Crews ◽  
Menyhárt B. Sárosi ◽  
Cristina M. Daniel ◽  
Kebreab Ghebreselasie ◽  
...  
Keyword(s):  
Cisplatin Resistance ◽  
Cyclooxygenase Inhibitors ◽  
Cisplatin Analogues

Amino acid-linked platinum(ii) analogues have altered specificity for RNA compared to cisplatin

2014 ◽  
Vol 50 (30) ◽  
pp. 3918-3920 ◽  
Author(s):  
Keshab Rijal ◽  
Xun Bao ◽  
Christine S. Chow
Keyword(s):  
Amino Acid ◽  
Cisplatin Analogues ◽  
Charge Distributions

Cisplatin analogues containing ligands with altered sizes and charge distributions show different specificity for RNA compared to the parental compound.

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