Continuous stirring tank reactors are widely used in the chemical production process, which is always accompanied by nonlinearity, time delay, and uncertainty. Considering the characteristic of the actual reaction of the continuous stirring tank reactors, the fault detection problem is studied in terms of the T-S fuzzy model. Through a fault detection filter performance analysis, the sufficient condition for the filtering error dynamics is obtained, which meets the exponential stability in the mean square sense and the given performance requirements. The design of the fault detection filter is transformed into one that settles the convex optimization issue of linear matrix inequality. Numerical analysis shows the effectiveness of this scheme.