Trichilianones A-D, Novel Cyclopropane-Type Limonoids from Trichilia adolfi

The fractionation of an ethanol extract of the bark of Trichilia adolfi yielded four novel limonoids (trichilinones A-D, 1–4), with five fused rings and related to the hortiolide-type limonoids. Starting with an ε-lactone, which is α,β-unsaturated in trichilinones A and D (1 and 4), attached to a tetrahydrofuran ring that is connected to an unusual bicyclo [5.1.0] hexane system, joined with a cyclopentanone with a 3-furanyl substituent [(2-oxo)-furan-(5H)-3-yl in trichilinone D (4)], the four compounds isolated display a new 7/5/3/5/5 limonoid ring system. Their structures were established based on extensive analysis of NMR spectroscopic data. As the crude extract possessed anti-leishmanial properties, the compounds were assayed for cytotoxic and anti-parasitic activities in vitro in murine macrophages cells (Raw 264.7) and leishmania promastigotes (L. amazoniensis and L. braziliensis), respectively. The compounds showed moderate cytotoxicity (approximately 70 μg/mL), but are not responsible for the leishmanicidal effect of the extract.

Amphiphilic properties of alkoxyoligoethyleneglycol methacrylates and copolymers based on them

Based on the data on the distribution of alkoxyoligo(ethyleneglycol) methacrylates in the water-hexane system, the HLB values of the macromonomers are determined. A good correlation between the temperatures of phase transitions of copolymers of alkoxyoligo(ethyleneglycol) methacrylates in aqueous solutions and calculated HLB values of the original macromonomers was shown.