The Daniels College of Business at the University of Denver has shown resilience in navigating an increasingly turbulent environment. In working to transform itself, while still performing current activities, the College has pursued ambidexterity. That is, it has exploited its existing capabilities to deliver traditional academic programs and activities, while exploring new capabilities, academic programs, and activities that will help position the school for future growth. This effort started with revisions in the College’s strategy, structure, and mission, which were then followed by several operational changes. The depth and process of these changes are illustrated in the discussion of three significant initiatives: a focus on challenge-driven education, the launching of an online MBA, and the commencement of an executive PhD program. These changes have impacted enrollment as well as the College’s ability to consider and implement additional changes.