Sticks and Stones? Connecting Insurgent Propaganda with Violent Outcomes

In this paper, we analyze the relationship between ISIS propaganda content and ISIS-inspired attacks by those outside of the group’s control. We examine the content of ISIS’ English language magazines, as well as speeches by two of its top leaders. We find that statements made about enemy countries in most contexts are not associated with a higher likelihood of violence in those countries. However, when a country is mentioned in ISIS propaganda in the context of its participation in the air campaign, this corresponds to an increased likelihood that the country will experience a violent attack. This suggests that propaganda highlighting key military adversaries may play a role in directing attackers that are outside the control of the organization’s hierarchy to the group’s preferred targets.

Not Just Sticks and Stones: Psychological Abuse and Physical Violence among U.S. State Senators

In this study, we report results of a survey of U.S. state senators about their experiences of psychological abuse, physical violence, and sexualized abuse and violence on the job, as well as gender differences among senators. Overall, our results indicate that more than 80% of state senators reported having faced abuse and violence, and women senators reported more physical violence than men. Moreover, we found differences in the factors that contributed to abuse and violence among women and men state senators. Most notably, women with higher levels of power (party or committee leaders) were more likely than other women to experience psychological abuse and sexualized abuse and violence, and Democratic women senators faced more sexualized abuse and violence than Republican women. The implications for continued service by state senators in the face of these experiences, the likelihood of attracting future candidates, and the implications for gender diversity in office are explored.

Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila

Control of tyrosine phosphorylation is an essential element of many cellular processes, including proliferation, differentiation neurite outgrowth, and synaptogenesis. Receptor-like protein-tyrosine phosphatases (RPTPs) have cytoplasmic phosphatase domains and cell adhesion molecule (CAM)-like extracellular domains that interact with cell-surface ligands and/or co-receptors. We identified a new ligand for the Drosophila Lar RPTP, the immunoglobulin superfamily CAM Sticks and Stones (Sns). Lar is orthologous to the three Type IIa mammalian RPTPs, PTPRF (LAR), PTPRD (PTPδ), and PTPRS (PTPσ). Lar and Sns bind to each other in embryos and in vitro. The human Sns ortholog, Nephrin, binds to PTPRD and PTPRF. Genetic interaction studies show that Sns is essential to Lar’s functions in several developmental contexts in the larval and adult nervous systems. In the larval neuromuscular system, Lar and sns transheterozygotes (Lar/sns transhets) have synaptic defects like those seen in Lar mutants and Sns knockdown animals. Lar and Sns reporters are both expressed in motor neurons and not in muscles, so Lar and Sns likely act in cis (in the same neurons). Lar mutants and Lar/sns transhets have identical axon guidance defects in the larval mushroom body in which Kenyon cell axons fail to stop at the midline and do not branch. Pupal Kenyon cell axon guidance is similarly affected, resulting in adult mushroom body defects. Lar is expressed in larval and pupal Kenyon cells, but Sns is not, so Lar-Sns interactions in this system must be in trans (between neurons). Lastly, R7 photoreceptor axons in Lar mutants and Lar/sns transhets fail to innervate the correct M6 layer of the medulla in the optic lobe. Lar acts cell-autonomously in R7s, while Sns is only in lamina and medulla neurons that arborize near the R7 target layer. Therefore, the Lar-Sns interactions that control R7 targeting also occur in trans.