This chapter looks at the dozens of enemies Poe acquired in the course of his career. Instead of understanding these enemies as a phenomenon peculiar to Poe and his individual psychological state, the chapter argues that enemies were a kind of dark, unconscious side of the friendship culture that prevailed in the magazine industry in the early nineteenth-century United States. At a time when magazines depended for their content and profitability on the voluntary labor of unpaid contributors, friendship culture, in which friends volunteered to write for the periodicals of other friends, was crucial to the functioning of the magazine publishing economy. But hatred and rage were also productive energies, goading writers to write for free for magazines as easily as friendly indebtedness. Examining Poe’s rancorous relationships with his fellow authors, this article argues that Poe’s many enemies were part of a larger economy of violent invective and grudges that formed a companion to the culture of friendship.