Effects of controlled burn rice husk ash on geotechnical properties of the soil

Pozzolanic reactions of RHA entirely depends on controlled burning condition. The current study illustrates the effects of controlled burn rice husk ash (RHA) on the geotechnical properties of A-2-4 type soil. The compactibility, bearing capacity, compressive strength, and shear strength were investigated as the important geotechnical properties on soil with 0%, 5%, 10%, and 15% of RHA admixtures. Considering the 7-day moist curing, standard Proctor compaction tests, California Bearing Ratio (CBR) tests, Unconfined Compressive Strength (UCS) tests, Consolidated-Drained (CD) Triaxial Compression tests, and Scanning Electron Microscopy (SEM) tests were conducted on soil-RHA combinations. The test results showed that the optimum moisture content increased, but MDD reduced with the increment of RHA content. Soil with 5% RHA showed the increase of CBR (39.5%), UCS (6.0%), modulus of deformation (56.3%), cohesion (11.8%), and angle of internal friction (6.3%) compared to control specimen which indicated that the application of burnt RHA at a controlled temperature significantly enhanced the geotechnical properties of soil. SEM image on soil with 5% RHA also observed the best microstructural development.

Experimental models for controlled burn injuries in rats: a systematic analysis of original methods and burn devices

AIM Despite a wide variety of models found in literature, choosing the right one can be difficult as many of them are lacking precise methodology. This study aims to analyze and compare original burn models in terms of burn device and technique, parameters, and wound depth assessment. METHODS A systematic search was performed according to PRISMA guidelines on studies describing original experimental burn models in rats. The adapted PICO formula and ARRIVE checklist were followed for inclusion and assessment of quality of studies. Characteristics of animals, burn technique, burn parameters and method of histological confirmation of burn depth were recorded. RESULTS Twenty-seven studies were included in the final analysis. Most studies used direct contact with skin for burn infliction (n=20). The rat’s dorsum was the most common site (n=18). Ten studies used manually controlled burn devices, while ten designed automatic burn devices with control over temperature (n=10), exposure time (n=5), and pressure (n=5). Most studies (n=7) used a single biopsy taken from the center of the wound to confirm burn depth immediately after burn infliction. CONCLUSION From the wide variety of burn models in current literature, our study provides an overview of the most relevant experimental burn models in rats aiding researchers to understand what needs to be addressed when designing their burn protocol. Models cannot be compared as burn parameters variate significantly. Assessment of burn depth should be done in a standardized, sequential fashion in future burn studies to increase reproducibility.

mSphere of Influence: a Controlled Burn—Pathogen Manipulation of the Dynamic Chemistry That Results from Inflammation

ABSTRACT Neal Hammer works in the field of bacterial pathogenesis, metabolism, and antibiotic resistance. In this mSphere of Influence article, he reflects on how “Gut inflammation provides a respiratory electron acceptor for Salmonella” by Winter and colleagues (S. E. Winter, P. Thiennimitr, M. G. Winter, B. P. Butler, et al., Nature 467:426–429, 2010, https://doi.org/10.1038/nature09415) made an impact on him by demonstrating that Salmonella enterica serotype Typhimurium metabolism is uniquely suited to exploit the chemical by-products that result from the host’s inflammatory response.

Efficiency evaluation of the dimebon gel in experiment

The article presents the characteristics of the Dimebon drug, different ways of drug delivery to organs and tissues. The purpose of this study was to determine the Dimebon gel effect on inflammation in experimental animals in comparison with other gels. It was found the criteria of evaluation and formulation of algorithms experiment. It was revealed the absence of systemic toxicity of the Dimebon gel, the severity of their de-congestant effect (77.04%) and a superior action with microcapsules Dimebon (69.63%). The Dimebon gel is not inferior to the Fenistil gel. This is explained by the action of the test Dimebon, because the effectiveness of gel base in 3,2 times is inferior to the subject gel. Regenerative activity the Dimebon gel is controlled burn time of rejection of the scab, which was lower by 2 days than when using the Fenistil gel and 4 days after the Dimebon gel microcapsules.