THE COMPARISON OF RAMANIA (Bouea macrophylla Griff) AND BINJAI (Mangifera caesia) LEAVES EXTRACT GEL EFFECT ON COLLAGEN DENSITY

Background: The extract of ramania Bouea macrophylla Griff) and binjai (Mangifera caesia) leaf have flavonoid compounds that function as antioxidants to balance the amount of Reactive Oxygen Species (ROS) in tissues and optimize wound healing by helping synthesis of hydroxyproline which is used as a collagen synthesis material. Objective: To compare the effect of 15% concentration of ramania leaf extract gel, 15% concentration of binjai leaf extract gel on collagen density in back incision wounds of male Wistar rats on day 7 and day 14. Methods: This study used a true experimental design with a posttest-only with control group design. The study sample used male wistar rats that were healthy and active, aged 2-3 months with a body weight of 250-300 grams. The total sample was 18 rats divided into 6 groups. The 15% concentration of ramania and binjai leaves was given topically, then the rats were euthanized on the 7th and 14th day. Collagen index measurement was using hydroxyproline concentration. Results: Two-way Anova data analysis showed a significant value of 0.00 (p<0.05), which means that there was a difference in effect between the treatment gel and wound day. Bonferroni Post Hoc test showed a significant value in all treatment gel groups. Conclusion: There is a difference in the effect of 15% concentration of ramania leaf extract gel and 15% concentration of binjai extract gel on collagen density. Binjai leaf extract gel at 15% concentration is more effective for collagen density than Ramania leaf extract at 15% concentration and placebo. Keywords : Binjai Leaf Extract Gel, Collagen, Hydroxyproline, Ramania Leaf Extract Gel.

Study of the Strength of Disintegrated Carbonaceous Mudstone Modified with Nano-Al2O3 and Cement

Embankments filled with disintegrated carbonaceous mudstone (DCM) are prone to uneven settlements because of water-softening property and secondary disintegration of carbonaceous mudstone. To address this problem, nano-Al2O3 and cement were proposed in this study to improve the strength of DCM. Many nano-Al2O3- and cement-modified DCM (NACDCM) specimens with various nano-Al2O3 contents were prepared. Unconfined compression tests and triaxial compression tests were performed to examine the strengths of NACDCM under different conditions. Moreover, X-ray diffraction (XRD) analyses and scanning electron microscopy (SEM) observations were performed to reveal the microscopic mechanism for modification of the NACDCM. Macroscopic results showed that the unconfined compressive strength of NACDCM reached maximum when the nano-Al2O3 content was 0.2%. The cohesion showed positive correlation with nano-Al2O3 content while the angle of internal friction presented negative correlation with nano-Al2O3 content. Moreover, microscopic results indicated that nano-Al2O3 and cement improved the strength of NACDCM, mainly through cement hydration reaction, pozzolanic reaction, ion exchange, gel effect and filling effect.