Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa

2009 ◽  
Vol 98 (1) ◽  
pp. 349-361 ◽  
Author(s):  
Hui Ouyang ◽  
Weiqing Chen ◽  
Thomas E. Andersen ◽  
Bente Steffansen ◽  
Ronald T. Borchardt ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Metabolic Enzymes ◽  
Opioid Peptide ◽  
Intestinal Cell ◽  
Cyclic Prodrugs

Role of enteric glial cells in the toxicity of phycotoxins: Investigation with a tri-culture intestinal cell model

2021 ◽  
Vol 351 ◽  
pp. 89-98
Author(s):  
Océane Reale ◽  
Dorina Bodi ◽  
Antoine Huguet ◽  
Valérie Fessard
Keyword(s):  
Glial Cells ◽  
Cell Model ◽  
Intestinal Cell ◽  
Enteric Glial Cells

scholarly journals Electroencephalographic assessment of the role of δ receptors in opioid peptide - induced seizures

Neuropeptides ◽  
1984 ◽  
Vol 5 (1-3) ◽  
pp. 213-216 ◽  
Author(s):  
Frank C. Tortella ◽  
Lydia Robles ◽  
Henry I. Mosberg ◽  
John W. Holaday
Keyword(s):  
Opioid Peptide

Intestinal Lesions Containing Coronavirus-like Particles in Neonatal Necrotizing Enterocolitis: An Ultrastructural Analysis

PEDIATRICS ◽  
1984 ◽  
Vol 73 (2) ◽  
pp. 218-224
Author(s):  
S. Rousset ◽  
O. Moscovici ◽  
P. Lebon ◽  
J. P. Barbet ◽  
P. Helardot ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Small Intestine ◽  
Necrotizing Enterocolitis ◽  
Intestinal Mucosa ◽  
Light And Electron Microscopy ◽  
Anaerobic Bacteria ◽  
Intestinal Lesions ◽  
Maternity Hospitals ◽  
Neonatal Necrotizing Enterocolitis

Since the outbreaks of neonatal necrotizing enterocolitis occurring in maternity hospitals of Paris and suburbs in 1979-1980, it has been possible to examine by light and electron microscopy gut specimens from ten newborns with this illness. Coronavirus-like particles, enclosed in intracytoplasmic vesicles of damaged epithelial cells of the intestinal mucosa, were observed in the small intestine, appendix, and colon. The ultrastructural study, supported by bacteriologic findings, suggests the role of coronavirus-like particles in the appearance of the lesions. Secondary proliferation of mainly anaerobic bacteria, probably responsible for pneumatosis, may aggravate the disease.

New Dimeric Tetrapeptide Enkephalin Analogues with Fiveor Six-Carbon Hydrophilic Spacers

1995 ◽  
Vol 50 (9) ◽  
pp. 1329-1334 ◽  
Author(s):  
I. Zajączkowski ◽  
J. Stępiński ◽  
A. Temeriusz ◽  
S. W. Tam
Keyword(s):  
Opioid Peptide ◽  
Enkephalin Analogues ◽  
Kappa Receptors ◽  
Kappa Receptor ◽  
Delta Receptors

AbstractTo investigate the role of distance between two opioid peptide pharmacophores on binding activities to delta, mu and kappa receptor in vitro, a number of new dimeric enkephalin analogues were synthesized in which two identical tetrapeptides: Tyr-D-Ala-Gly-Phe were connected together at their C-termini by α,ω-diamino-α,ω-dideoxyalditols. The length of the hydrophilic spacer (3 -6 carbons) did not affect the affinities for delta receptors, whereas the affinities for mu and kappa receptors were dependent on the length as well as the configuration of the spacer. The analogues had high affinities, and some of them possessed moderate delta selectivity.

The role of metabolic enzymes in insecticide-resistant colorado potato beetles

1994 ◽  
Vol 40 (4) ◽  
pp. 259-264 ◽  
Author(s):  
Joel M. Wierenga ◽  
Robert M. Hollingworth
Keyword(s):  
Metabolic Enzymes

scholarly journals Effect of Helicobacter pylori on Polymorphonuclear Leukocyte Migration across Polarized T84 Epithelial Cell Monolayers: Role of Vacuolating Toxin VacA and cagPathogenicity Island

2000 ◽  
Vol 68 (9) ◽  
pp. 5225-5233 ◽  
Author(s):  
Véronique Hofman ◽  
Vittorio Ricci ◽  
Antoine Galmiche ◽  
Patrick Brest ◽  
Patrick Auberger ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Polymorphonuclear Leukocyte ◽  
Broth Culture ◽  
Intestinal Cell ◽  
T84 Cells ◽  
Vacuolating Cytotoxin ◽  
Intestinal Cell Line ◽  
H Pylori

ABSTRACT Helicobacter pylori infection can induce polymorphonuclear leukocyte (PMNL) infiltration of the gastric mucosa, which characterizes acute chronic gastritis. The mechanisms underlying this process are poorly documented. The lack of an in vitro model has considerably impaired the study of transepithelial migration of PMNL induced by H. pylori. In the present work, we used confluent polarized monolayers of the human intestinal cell line T84 grown on permeable filters to analyze the epithelial PMNL response induced by broth culture filtrates (BCFs) and bacterial suspensions from different strains of H. pylori. We have evaluated the role of the vacuolating cytotoxin VacA and of the cagpathogenicity island (PAI) of H. pylori in PMNL migration via their effects on T84 epithelial cells. We noted no difference in the rates of PMNL transepithelial migration after epithelial preincubation with bacterial suspensions or with BCFs of VacA-negative or VacA-positive H. pylori strains. In contrast, PMNL transepithelial migration was induced after incubation of the T84 cells with cag PAI-positive and cagE-positiveH. pylori strains. Finally, PMNL migration was correlated with a basolateral secretion of interleukin-8 by T84 cells, thus creating a subepithelial chemotactic gradient for PMNL. These data provide evidence that the vacuolating cytotoxin VacA is not involved in PMNL transepithelial migration and that the cag PAI, with a pivotal role for the cagE gene, provokes a transcellular signal across T84 monolayers, inducing a subepithelial PMNL response.

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