Factors that Restrict the Cell Permeation of Cyclic Prodrugs of an Opioid Peptide, Part 4: Characterization of the Biopharmaceutical and Physicochemical Properties of Two New Cyclic Prodrugs Designed to be Stable to Oxidative Metabolism by Cytochrome P-450 Enzymes in the Intestinal Mucosa

2012 ◽  
Vol 101 (9) ◽  
pp. 3500-3510 ◽  
Author(s):  
Rebecca Nofsinger ◽  
Ronald T. Borchardt
Keyword(s):  
Physicochemical Properties ◽  
Intestinal Mucosa ◽  
Oxidative Metabolism ◽  
Opioid Peptide ◽  
Cyclic Prodrugs ◽  
Cytochrome P 450

Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa

2009 ◽  
Vol 98 (1) ◽  
pp. 349-361 ◽  
Author(s):  
Hui Ouyang ◽  
Weiqing Chen ◽  
Thomas E. Andersen ◽  
Bente Steffansen ◽  
Ronald T. Borchardt ◽  
...  
Keyword(s):  
Intestinal Mucosa ◽  
Metabolic Enzymes ◽  
Opioid Peptide ◽  
Intestinal Cell ◽  
Cyclic Prodrugs

Opioid Peptide Receptor Studies. 13. Characterization of Opioid Antagonists With the [35S]GTP-γ-S Binding Assay

Analgesia ◽  
1999 ◽  
Vol 4 (1) ◽  
pp. 27-32 ◽  
Author(s):  
John S. Partilla ◽  
F. Ivy Carrol ◽  
James B. Thomas ◽  
Kenner C. Rice ◽  
Dennis M. Zimmerman ◽  
...  
Keyword(s):  
Binding Assay ◽  
Opioid Peptide ◽  
Opioid Antagonists ◽  
Peptide Receptor

Synthesis, Characterization, and Dynamic Behavior of Well-defined Dithiomaleimide-functionalized Maltodextrins

2020 ◽  
Vol 17 (2) ◽  
pp. 85-89
Author(s):  
Francisco J. Hidalgo ◽  
Nathan A.P. Lorentz ◽  
TinTin B. Luu ◽  
Jonathan D. Tran ◽  
Praveen D. Wickremasinghe ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Dynamic Behavior ◽  
Industrial Applications ◽  
19F Nmr ◽  
Nmr Studies ◽  
Synthetic Pathway ◽  
End Groups ◽  
Sugar End

: Maltodextrins have an increasing number of biomedical and industrial applications due to their attractive physicochemical properties such as biodegradability and biocompatibility. Herein, we describe the development of a synthetic pathway and characterization of thiol-responsive maltodextrin conjugates with dithiomaleimide linkages. 19F NMR studies were also conducted to demonstrate the exchange dynamics of the dithiomaleimide-functionalized sugar end groups.

Chemical characterization of tequila maturation process and their connection with the physicochemical properties of the cask

2021 ◽  
Vol 98 ◽  
pp. 103804
Author(s):  
Walter M. Warren-Vega ◽  
Rocío Fonseca-Aguiñaga ◽  
Linda V. González-Gutiérrez ◽  
Francisco Carrasco-Marín ◽  
Ana I. Zárate-Guzmán ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Chemical Characterization ◽  
Maturation Process
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