Famotidine as Urokinase Inhibitor in Anaphylactic Shock

A QSAR study was performed on a series of naphthalene cyclohexane amines derivate with experimentally determine constant of inhibition (Ki ) in order to indentify a potent human urokinase inhibitor. A QSAR model was build using artificial neural networks (ANN). Model was used for screening of compounds with potent urokinase inhibitory properties and to compute Ki of resulted screening compounds. Compound with best Ki was chosen for discussion. An induced fit docking (protein - ligand) and a protein –protein docking were used in results discussion. A isoquinoline –diol base derivate (Famotidione) resulted to have urokinase inhibitory properties.