321 Improvement of barrier impairment by topical application of a dual plasmin and urokinase inhibitor

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.

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Exacerbation of atopic dermatitis. Production by topical application of retinoic acid

Archives of Dermatology ◽

10.1001/archderm.105.3.405 ◽

1972 ◽

Vol 105 (3) ◽

pp. 405-406 ◽

Cited By ~ 1

Author(s):

G. G. Krueger

Keyword(s):

Atopic Dermatitis ◽

Retinoic Acid ◽

Topical Application

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Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation

Photodermatology Photoimmunology & Photomedicine ◽

10.1034/j.1600-0781.2000.d01-18.x ◽

2000 ◽

Vol 16 (3) ◽

pp. 125-128 ◽

Cited By ~ 19

Author(s):

C. M. Schempp ◽

R. Ludtke ◽

B. Winghofer ◽

J. C. Simon

Keyword(s):

Topical Application ◽

Hypericum Perforatum ◽

Skin Sensitivity ◽

St John’S Wort ◽

St John's Wort

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Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽

10.1038/oby.2012.166 ◽

2012 ◽

Cited By ~ 2

Author(s):

Gong-Rak Lee ◽

Mi Kyung Shin ◽

Dong-Joon Yoon ◽

Ah-Ram Kim ◽

Rina Yu ◽

...

Keyword(s):

Topical Application ◽

High Fat Diet ◽

Obese Mice ◽

High Fat ◽

Visceral Adipose

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Topical application of solubilized Reseda luteola extract inhibits ultraviolet B-induced inflammation in human volunteers in vivo

Planta Medica ◽

10.1055/s-0029-1234772 ◽

2009 ◽

Vol 75 (09) ◽

Author(s):

F Casetti ◽

W Jung ◽

U Wölfle ◽

J Reuter ◽

K Neumann ◽

...

Keyword(s):

Topical Application ◽

Ultraviolet B ◽

Human Volunteers

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Purification and Characterization of Tissue-Type Plasminogen Activator in Maxillary Mucosa with Chronic Inflammation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657879 ◽

1985 ◽

Vol 54 (02) ◽

pp. 485-489 ◽

Cited By ~ 3

Author(s):

Yukiyoshi Hamaguchi ◽

Masuichi Ohi ◽

Yasuo Sakakura ◽

Yasuro Miyoshi

Keyword(s):

Plasminogen Activator ◽

Chronic Inflammation ◽

Gel Filtration ◽

Potassium Acetate ◽

Tissue Type ◽

Purification And Characterization ◽

Tissue Type Plasminogen Activator ◽

Urokinase Inhibitor ◽

Type Plasminogen Activator

SummaryTissue-type plasminogen activator (TPA) was purified from maxillary mucosa with chronic inflammation and compared with urokinase. Purification procedure consisted of the extraction from delipidated mucosa with 0.3M potassium acetate buffer (pH 4.2), 66% saturation of ammonium sulfate, zinc chelate-Sepharose, concanavalin A-Sepharose and Sephadex G-100 gel filtration chromatographies.The molecular weight of the TPA was approximately 58,000 ± 3,000. Its activity was enhanced in the presence of fibrin and was quenched by placental urokinase inhibitor, but not quenched by anti-urokinase antibody. The TPA made no precipitin line against anti-urokinase antibody, while urokinase did.All these findings indicate that the TPA in maxillary mucosa with chronic inflammation is immunologically dissimilar to urokinase and in its affinity for fibrin.

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