Natural Treatment
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2021 ◽  
Vol 43 (2) ◽  
pp. 1171-1187
Min Hye Kang ◽  
Gwi Yeong Jang ◽  
Yun-Jeong Ji ◽  
Jeong Hoon Lee ◽  
Su Ji Choi ◽  

Melanin is a brown or black pigment that protects skin from ultraviolet radiation and reactive oxygen species (ROS). However, overproduction of melanin is associated with lentigines, melasma, freckles and skin cancer. Licorice has shown antioxidant, anti-tumor, anti-platelet, anti-inflammatory and immunomodulatory activities and is used as a natural treatment for skin whitening. We aimed to confirm the potential of Wongam, a new cultivar of licorice developed by the Rural Development Administration (RDA), as a whitening agent in cosmetics. In addition, we verified the effect of heat treatment on the bioactivity of licorice by comparing antioxidant and anti-melanogenic activities of licorice extract before and after heating (130 °C). The heat-treated licorice extract (WH-130) showed higher radical-scavenging activities in the ABTS+ (2,2′-azino-bis-(3-ethylbenzothiazolin-6-sulfonic acid) diammonium salt) and DPPH (2,2-diphenyl-1-picrylhydrazyl) assays. In addition, WH-130 inhibited melanogenesis more effectively due to downregulation of tyrosinase in B16F10 melanoma cells than non-heated licorice extract. Moreover, heat treatment increased total phenolic content. In particular, isoliquiritigenin, an antioxidant and anti-melanogenic compound of licorice, was produced by heat treatment. In conclusion, WH-130, with increased levels of bioactive phenolics such as isoliquiritigenin, has potential for development into a novel skin whitening material with applications in cosmetics.

Shubhada V Mangrilkar ◽  
Dhanashri Tikaram Jawal ◽  
Prasad Sherekar ◽  
Dinesh R Chaple

Silicosis is a possibly deadly, irreversible, fibrotic pneumonic sickness that may create resulting to the inward breath of a lot of silica dust over the long haul. As a rule, silicosis just creates resulting to significant word related presentations. The sickness has a long idleness period and may clinically present as an intense, quickened, or ongoing infection.In this audit the medicines that can lessen the aggravation and scarring in which are as nodular injuries in the upper projections of the lungs. The principle point of audit is to the likely home grown treatment for silicosis. This survey zeroed in on different medicines which incorporate natural plants, neutraceuticals, polyherbals, and herbominerals and furthermore cell based treatment for silicosis.From that review we presume that the natural treatment which is utilized in treatment of silicosis is potential treatments which incorporate huge quantities of home grown plants, polyherbals, neutraceuticals and herbominerals likewise incorporate the new treatment for silicosis is the cell based treatment.

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3927
Alice Turdo ◽  
Antonino Glaviano ◽  
Giacomo Pepe ◽  
Federica Calapà ◽  
Stefania Raimondo ◽  

Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle to be tackled. Thus, new treatment approaches are needed to effectively improve patient outcomes. Compelling evidence demonstrated that cancer stem cells (CSCs) are responsible for treatment failure and relapse. New natural treatment approaches showed capabilities to selectively target the CSC subpopulation by rendering them targetable by standard cytotoxic compounds. Herein we show the anti-cancer properties of the polymethoxyflavones and prenylflavonoids extracted from Citrus sinensis and Humulus lupulus, respectively. The natural biofunctional fractions, singularly and in combination, reduced the cell viability of CRC stem cells (CR-CSCs) and synergized with 5-fluorouracil and oxaliplatin (FOX) chemotherapy. These phenomena were accompanied by a reduced S and G2/M phase of the cell cycle and upregulation of cell death-related genes. Notably, both phytoextracts in combination with FOX thwarted stemness features in CR-CSCs as demonstrated by the impaired clonogenic potential and decreased Wnt pathway activation. Extracts lowered the expression of CD44v6 and affected the expansion of metastatic CR-CSCs in patients refractory to chemotherapy. Together, this study highlights the importance of polymethoxyflavones and prenylflavonoids as natural remedies to aid oncological therapies.

2021 ◽  
Vol 6 (1) ◽  
pp. 1
Arif Budi Darmawan ◽  
Alfira Nuarifia Handitasari

The emergence of modernization and globalization, followed by technology, information, and communication, leads Javanese millennial women to start using modern beauty treatment. On the other side, there are groups of millennial women who prefer to use traditional treatment. Research on traditional treatments and Jamu (Indonesian herbal medicine) are mostly focus on its function rather than reasons of people using it. This study explores the factors and reasons of millennial women to return to use traditional beauty treatment rather than modern one. This study applied qualitative in particular phenomenology to explain this trend and to understand the meaning from the perspective of users. This research conducted in Yogyakarta Special Region and involved eight millennial women. Using theory of Ulrich Beck on risk society, this study suggests that the trend of back to natural treatment among millennials is a form of a reflexive modernity. There are reasons of young women to do this; 1) previous experience of adverse effect of modern beauty treatment; 2) the price of traditional beauty treatment is more affordable than modern one; 3) the feasibility of getting basic ingredients for traditional beauty treatment; 4) belief about the good effect of traditional beauty treatment rather than modern one.

Candace Barnes ◽  
Rebecca Barber ◽  
Keith R. Schneider ◽  
Michelle D. Danyluk ◽  
Anita C. Wright ◽  

Human norovirus (HuNoV) is the leading causative agent of foodborne outbreaks and is associated with the second most prevalent cause of waterborne infections in the United States. The goal of this research was to investigate the antiviral activity of chitosan microparticles (CM) against HuNoV GII.4 Sydney and its cultivable surrogate, Tulane virus (TuV), in suspensions mimicking fecally-contaminated water. CM was prepared by crosslinking chitosan molecules with sodium sulfate, and then its anti-noroviral activity was assessed using infectivity assay on TuV and RT-qPCR on TuV and HuNoV. A 3% CM suspension in PBS (pH 7.2) showed binding to TuV particles but with a negligible impact on virus infectivity (p>0.05). TuV and HuNoV suspended in fecal suspensions showed a 1.5-log10 reduction in genomic copies per ml following a 10-min contact time (p<0.05). Despite the negligible impact on viral infectivity, CM moderately binds to virus particles and helps purify environmental water by removing infectious virus particles. In this study, TuV served as a suitable surrogate for HuNoV by showing a similar log10 reduction in fecal suspension. Overall, the outcomes of thisresearch highlight the potential application of CM as a novel, natural treatment to minimize the spread of water-transmitted viral pathogens.

Chemosphere ◽  
2021 ◽  
pp. 131529
C.A. Mendieta-Pino ◽  
S.O. Pérez-Báez ◽  
A. Ramos-Martín ◽  
F. León-Zerpa ◽  
S. Brito-Espino

2021 ◽  
Vol 36 (2spl) ◽  
pp. 555-562
Ágnes Erzsébet HOJCSKA ◽  
Zoltán SZABÓ ◽  

The aim of the research is to reveal the spatial inequalities of the natural treatment factors in Hungary and the medicinal water institutions built on them, with the help of spatial research methods on the basis of secondary data. Due to the favorable geographical conditions of Central Europe, the Carpathian Basin has a considerable amount of natural resources. With the appreciation of health, in our days they represent significant value because they are becoming increasingly important in tourist services aimed at maintaining and restoring health. In Hungary, there are outstanding opportunities for this in health tourism, which provides a wide range of medical services, including medical tourism based on natural treatment factors. In order to achieve the set research goal, we used the range of the data set (range-ratio), the dispersion range (range), the relative range (relative range) and the dual measure (Éltető–Frigyes-index) as spatial inequality test methods for the geographically based examination of Hungary's natural treatment factors and the system of medicinal water institutions. The research results show that the spatial polarisation of natural treatment factors and the medicinal water institutions based on them show significant inequalities in Hungary. It has been proved that the development of the counties is outstanding in terms of medicinal waters and medicinal bath, and the spatial difference is also the lowest in the case of these treatment factors.

Antonio Tursi ◽  
Marcello Picchio ◽  
Walter Elisei ◽  
Leonardo Allegretta ◽  
Pierluigi Benedicenti ◽  

Background: Although FD may affect up to 10% of the general population, the therapy for FD is not standard. Recently, ginger-based food supplements have been proposed in order to restore FD symptoms. Our aim was to assess the efficacy of a new nutraceutical formulation containing extract of gingerol and thymus as a possible natural treatment in managing the symptoms of functional dyspepsia (FD). Methods: We retrospectively analyzed the efficacy and safety profiles of a nutraceutical formulation containing Zingiber of¬ficinalis root extract and a standardized Thymus extract. It was adminis¬tered as 1 ml/day twice a day for 90 days. Patients were assessed at baseline and af¬ter 1, 2 and 3 months of treatment, following a month of pharmacological washout by completing a questionnaire reporting the trend of the following symptoms: epigastric pain, epigastric heaviness, early satiety, belching, and regurgitation. Every symptom was assessed by a Visual Analogic Scale (VAS), ranging from 0= absence to 10= maximal severity. Results: We enrolled 272 patients (99 males and 173 females; median IQR age 49.5, 36-64 yrs). Obesity (BMI>30) was present in 28 (12.5%) patients; smokers were 83 (30.5%); and comorbidities were present in 107 (39.3%) patients. Improvement of symptom scores during treatment and one month after its suspension was extremely significant (p<0.000). Conclusion: This large study found that nutraceutical formulation could be one of the tools for an empirical approach to treat patients with FD, especially when a non-conventional drug treatment is preferable for the patient and considered suitable by the physician.

2021 ◽  
Vol 12 (2) ◽  
pp. 1546-1551
Shanmugasundaram Gouthaman ◽  
Roshni Saravanan ◽  
Jayaprakash Narayanan ◽  
Arputha Selvi A

Breast cancer is one of the top-ranked cancers affecting women in the world. Although there are approved standard regimens for treatment, due to toxicological side effects, there is a demand for novel anti-cancer drugs with minimal adverse effects leading to the emergence of Indian Systems of Medicine. Natural treatment modalities such as Siddha, Ayurveda and Unani are emerging and have been given gaining importance in recent times. They have been in vogue for centuries together and have shown better prognosis over a period of time with lesser toxicity and admiring oncological results. The presentation is an evidence-based report on the cure of breast cancer using Siddha chemotherapeutic formulations.

Nina Werkhäuser ◽  
Andreas Bilstein ◽  
Kathrin Mahlstedt ◽  
Uwe Sonnemann

Abstract Introduction Symptomatic relief of acute rhinosinusitis is commonly achieved with nasal decongestants. The current observational study investigated the efficacy and safety of treatment of acute rhinosinusitis with Ectoin® Rhinitis Spray compared to or in combination with Xylometazoline-containing decongesting nasal spray. Methods Patients with acute rhinosinusitis applied either Ectoin® Rhinitis Spray, Xylometazoline nasal spray or a combination of both products. Rhinosinusitis symptoms were assessed, and nasal oedema and endonasal redness were determined by rhinoscopy. Patient diaries based on the validated SNOT (Sino Nasal Outcome Test) questionnaire evaluated rhinosinusitis parameters over time and influences of the disease on quality of life. Following treatment, investigators and patients judged the efficacy and tolerability. Results Ectoin® Rhinitis Spray diminished common rhinosinusitis symptoms such as nasal obstruction, nasal secretion, facial pain/headache, and smell/taste impairment. Upon treatment over 7 days, rhinosinusitis sum scores decreased statistically significantly (p < 0.001) by − 64.25%, which was comparable to that achieved with Xylometazoline-containing decongesting nasal spray (− 67.60%). No side effects were observed during treatment with Ectoin® Rhinitis Spray, whereas treatment with Xylometazoline-containing nasal spray resulted in nasal mucosa dryness. Concomitant treatment with both products diminished the development of nasal dryness and required fewer applications of Xylometazoline-containing nasal spray. Conclusion Ectoin® Rhinitis Spray is an effective, natural treatment option for acute rhinosinusitis, which may be used as monotherapy or as add-on treatment with a Xylometazoline-containing nasal spray. The concomitant use of Ectoin® Rhinitis Spray might reduce the needed dose of decongestant nasal spray and counteract bothersome side effects such as dry nasal mucosa. Trial registration The current study was registered in the database under the identifier: NCT03693976 (date of registration: Oct 3, 2018).

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