Behaviour of relative evapotranspiration with agrometeorological stress indices in wheat

Complex behaviour of stress indices with relative evapotranspiration was observed in early and late sown wheat, however, under normal sown conditions it was linearly decreasing. Predawn leaf water potential and transpiration rate proved to be a stable stress index parameter for characterizing the internal moisture status in the plant as compared to the canopy temperature and stomatal resistance under stress conditions in wheat. Since it is easy to quantify canopy/leaf temperature and within seasonal variations it is widely used for scheduling irrigation and quantigying moisture stress effects on growth and development in wheat.

Chronic Stress Effects on Tumor: Pathway and Mechanism

Chronic stress is an emotional experience that occurs when people encounter something they cannot adapt to. Repeated chronic stress increases the risk of a variety of diseases, such as cardiovascular disease, depression, endocrine disease, inflammation and cancer. A growing body of research has shown that there is a link between chronic stress and tumor occurrence in both animal studies and clinical studies. Chronic stress activates the neuroendocrine system (hypothalamic-pituitary-adrenal axis) and sympathetic nervous system. Stress hormones promote the occurrence and development of tumors through various mechanisms. In addition, chronic stress also affects the immune function of the body, leading to the decline of immune monitoring ability and promote the occurrence of tumors. The mechanisms of chronic stress leading to tumor include inflammation, autophagy and epigenetics. These factors increase the proliferation and invasion capacity of tumor cells and alter the tumor microenvironment. Antagonists targeting adrenergic receptors have played a beneficial role in improving antitumor activity, as well as chemotherapy resistance and radiation resistance. Here, we review how these mechanisms contribute to tumor initiation and progression, and discuss whether these molecular mechanisms might be an ideal target to treat tumor.

Homeostasis and adaptation: pathophysiological aspects of somato-vegetative interaction in ontogenesis

The review presents information on the somatovegetative interaction of blood circulation and respiration from the point of view of the views of Professor Yu.P. Pushkarev. Data are presented that speak of the complexity and complexity of the problem of homeostasis and adaptation, the unresolved many issues that are important for understanding the stability of the internal environment of the body and establishing the limits of the norm. It has been shown that within the neurohumoral system of the body, the interaction of various components of functional systems is constantly carried out, ensuring the conjugation of respiration and blood circulation with the formation of intersystem links. Some aspects of the formation of functions in animals and humans in postnatal ontogenesis are considered. It is emphasized that homeostasis is an internal balance of indicators in the body, but its values are constantly changing due to the center-peripheral integration of functions. It was emphasized that the process of achieving a beneficial adaptive result is characterized by the asymmetry of physiological indicators, and the intersystem interaction ensures the balancing of homeostasis constants in terms of adaptation to environmental conditions. It has been shown that over-threshold environmental influences and homeostasis parameters shift in the body, compensatory-adaptive reactions occur, aimed at maintaining a certain level of stationary state, eliminating or limiting the effect of the harmful factor and optimizing the interaction of the organism and the environment due to the formation of intersystem links. Analyzed the pathophysiological mechanisms of changes in function in certain diseases and stress effects. It is shown that the further study of the somatovegetative interaction in the context of the ideas of Yu.P. Pushkarev will allow revealing the true mechanisms of synchronization of functions in the organism of animals and humans in order to understand its existence as an independent self-regulating system.

A new desorption-induced permeability dynamic model and its application in primary coalbed methane recovery

In the process of dewatering and recovery of coalbed methane, coal permeability exhibits a quite unique feature due to the interference of matrix shrinkage and stress effects. A new theoretical dynamic model was proposed for coal permeability based on the assumptions of matchstick geometry of the coal and uniaxial strain condition. Distinct from previous models such as P&M and S&D models, our model relates the gas-sorption-reduced strain to the change of surface energy of coal solids. One of the advantages of this model is that it does not require the sorption-reduced strain as an essential input, and therefore eliminates the related laborious and expensive laboratory measurement. The model was validated by fitting it to two sets of public data and shows an excellent match with the observed data. The results also indicate that our model has a better performance in predicting the permeability dynamics than P&M and S&D models. Additionally, a sensitivity analysis of the effect of input parameters on permeability dynamics was conducted by gray-relation theory, and the initial porosity and reservoir temperature are demonstrated to exert a most distinguished effect on the permeability dynamics. Finally, the proposed model was incorporated into a numerical simulator and successfully applied to conduct a history match of the gas and water production rate in a developed territory.