FULL TERM BABIES;

Introduction: Perinatal asphyxia is one of the most common causes of neonatalmorbidity and mortality in most countries of the world. The objective of my study was to assessthe correlation of clinical findings of perinatal asphyxia with cranial sonography in full termbabies. Study Design: Retrospective study. Setting: Neonatal Intensive Care Unit of Children’sHospital Multan. Period: January 2016 to October 2016. Material and Methods: 100 fullterm babies having history of delayed cry were scanned within three days of birth in NeonatalIntensive Care Unit of Children’s Hospital Multan. Clinically findings including full term babies,birth weight, grunting, cyanosis history of mode delivery, resuscitation history, delayed cry andhypoxic ischemic encephalopathy (HIE) grades were taken from baby’s hospital file record andstandard images including coronal and sagittal plans were taken by Ultrasound machine probeof frequency 3-5 MHz. Findings were recorded on data collection sheets and spread on EXELsheets. Correlation was found by using SPSS software. Result: Out of 100 neonates 63 weremale and 37 were female with birth weight (2.4-3.6) having mean ± SD 3.08 ± 0.53. HIE grades(mild, moderate and severe) were found in 12, 83, 5 babies respectively and ultrasound grades0 (normal/ mild echogenic), grade 1 (moderate echogenic) and grade 2 (severe/generalizedechogenic) were found in 32, 52, 16 neonates respectively with r= 0.37 and P-value < 0.05showing moderate positive correlation. Conclusion: Cranial ultrasound is a good screeningtool to evaluate asphyxiated neonatal brain. It has a moderate positive correlation with clinicalfindings.

Assessment of Cranial Sonographic Findings of Hypoxic Ischemic Brain Injury in Perinatal Asphyxia

Background: In perinatal asphyxia, hypoxic ischemic brain injury remains most serious condition causing significant mortality and long term morbidity. Early detection of intracranial changes and its consequences will enhance timely intervention and better out come. Cranial sonography can be done to assess the abnormalities of brain in perinatal asphyxia. Objectives: The objective of this study was to evaluate usefulness of cranial sonography in perinatal asphyxia.Methods: This was an observational study conducted from March 2014 to February 2015 at department of radiology and imaging, Enam Medical College and Hospital. Total 100 neonates with perinatal asphyxia were included in this study. Cranial USG was done in all cases and sonographic abnormalities were evaluated.Result: 56 term (>37 weeks of gestation ) and 44preterm (<37 weeks of gestation ) newborn having birth asphyxia were taken as cases in this study. Common cranial sonographic findings of preterm babies were periventricular leukomalacia 29% (13), germinal matrix hemorrhage 14% (6), Intraventricular hemorrhage 11% (5) cerebral oedema 7% (3) and normal 39% (17). Common cranial USG findings in term babies were cerebral oedema 43% (24), intracerebral hemorrhage 5% (3), Focal cerebral infarct 4% (2), Intraventricular hemorrhage 2% (1) and normal 46% (26).Conclusion: This study found that transcranial sonography is useful to identify the abnormalities in brain of asphyxiated neonate and helps to predict the neurodevelopmental outcome. So proper management plan can be done.J MEDICINE January 2016; 17 (1) : 12-16

A Case of a Newborn with Agenesis of the Corpus Callosum Complicated with Ocular Albinism

Purpose: To report a case of ocular albinism found in a newborn infant in whom agenesis of the corpus callosum (ACC) was indicated in utero. Case Report: This study involved a female newborn who was delivered after a gestational period of 41 weeks. The patient was referred to the Obstetrics Department at Takatsuki Hospital, Takatsuki City, Japan, after the indication of ACC by magnetic resonance imaging (MRI) at a nearby clinic during the fetal period. At birth, the baby’s weight was 2,590 g, and ACC and ventricular enlargement were found by cranial sonography and cranial MRI. While initial ophthalmic findings noted partial loss of pigmentation of the iris and hypopigmentation of broad areas of the fundus in both eyes, nystagmus was not observed. The patient’s hair pigment was slightly diluted, and the color of her skin was slightly off-white. At 2 years after birth, obvious mental retardation was observed. With regard to other systemic findings, no apparent heart, kidney, or immune system abnormalities were found. Conclusion: Although the patient in question is presently growing without any major systemic problems, it will be necessary in the future to pay attention to any changes in systemic and ophthalmic findings.